Article
Multidisciplinary Sciences
Luis Becker, Christian Hipfl, Friederike Schoemig, Carsten Perka, Sebastian Hardt, Matthias Pumberger, Vincent Justus Leopold
Summary: This study retrospectively examined the effects of LSTV on DDH patients and the surgical treatment through PAO. The study found that patients with LSTV had significantly higher posterior-wall-index, but no significant differences were seen in other indices. There were also no significant differences in patient-reported outcomes before and after surgery. Therefore, even patients with LSTV can achieve good outcomes with PAO.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Rishi M. Kanna, Shanmuganathan Rajasekaran, Gregory D. Schroeder, Klaus Schnake, Alexander R. Vaccaro, Lorin Benneker, Cumhur F. Oner, Frank Kandziora, Emiliano Vialle
Summary: This paper reviews classification systems for sacral fractures and specifically discusses the impact of Isler fractures on the lumbo-sacral joint. Although there is a universal recognition of Isler fractures and their impact on LSJ integrity, there is a lack of clinical and biomechanical evidence regarding the concept of instability caused by a unilateral Isler fracture.
GLOBAL SPINE JOURNAL
(2022)
Article
Medicine, General & Internal
Diana Salas-Gomez, Mario Fernandez-Gorgojo, Pascual Sanchez-Juan, Maria Isabel Perez-Nunez, Esther Laguna-Bercero, Amaya Prat-Luri, David Barbado
Summary: This study analyzed the recovery of balance and other physical capacities in patients with bimalleolar fracture after surgery, and found that balance, hip strength, and ankle dorsiflexion ankle mobility were reliable indicators for assessing the functional status of these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Pascal Kouyoumdjian, Jad Mansour, Vincent Haignere, Christophe Demattei, Etienne Maury, David George, Remy Coulomb
Summary: This study aimed to investigate the influence of sagittal alignment of the spine on hip extension capacity. The results showed no significant difference in global extension reserve values between different sagittal alignment subtypes, but differences were observed in the intrinsic and extrinsic extension reserve.
GLOBAL SPINE JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Samir Benadjaoud, Mohamed Amine Benadjaoud, Jean-Pascal Lefaucheur, Violaine Plante-Bordeneuve
Summary: This study evaluated the ability of magnetic resonance neurography (MRN) to distinguish patients with hereditary transthyretin-related amyloidosis with polyneuropathy (ATTRv-PN) and assessed its prognostic value. The results showed that LSP root enlargement and increased intraneural signal were closely associated with clinical impairment in patients.
EUROPEAN RADIOLOGY
(2022)
Review
Chemistry, Analytical
Alireza Noamani, Negar Riahi, Albert H. Vette, Hossein Rouhani
Summary: Maintaining a stable upright posture is crucial for daily activities, and accurate methods for assessing static balance are important for identifying impairments and developing interventions. This review explores different methods to quantify standing balance and discusses advancements in using wearable IMUs to assess balance in older adults and individuals with iSCI. The inclusion of these groups is supported by their large representation among individuals with balance impairments.
Review
Health Care Sciences & Services
Joanna Aflalo, Flavien Quijoux, Charles Truong, Francois Bertin-Hugault, Damien Ricard
Summary: The postural balance of older adults is an important research area, as balance deficit is a significant risk factor for falls, which can result in severe injuries and death. This study proposes using a force platform to evaluate posturographic data and explore the effects of sensory deprivation or perturbation on postural control in the elderly.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Huey-Wen Liang, Shao-Yu Chi, Tzu-Ling Tai, Yue-Hua Li, Yaw-Huei Hwang
Summary: This study used virtual reality tracker-based posturography to measure hip and ankle strategies in standing posture of older and younger individuals, and compared the differences between the two age groups. The results showed that body displacement at the lumbar level played a more important role in hip strategies and was more effective in differentiating age-related changes compared to CoP parameters. Additionally, using a tracker-based posturography system provided a better understanding of the effects of age on postural control mechanisms.
Article
Psychology, Multidisciplinary
Rouven Kenville, Tom Maudrich, Sophie Korner, Johannes Zimmer, Patrick Ragert
Summary: This study found that 4 weeks of dynamic balance training improved static balance performance in school-aged gymnasts and football players. While both groups showed improvement in dynamic balance tasks, there were no significant changes in the two-legged balance tests.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Chemistry, Analytical
Barbora Kolarova, Miroslav Janura, Zdenek Svoboda, Petr Kolar, Dagmar Tecova, Milan Elfmark
Summary: The study assesses postural control strategies in individuals with transtibial amputation, finding that they bear less weight on the prosthetic leg and have reduced inclination toward it compared to controls. Weight-bearing symmetry and inclination toward the prosthetic leg were positively correlated with prosthesis use duration in tTTA group.
Article
Neurosciences
Alexander Simon, Tobias Rupp, Tim Hoenig, Eik Vettorazzi, Michael Amling, Tim Rolvien
Summary: The study indicates that postural stability is influenced by femoral BMD, age, and sex. Patients with a history of previous fragility fractures showed significant abnormality in postural stability, highlighting the importance of evaluating and managing impaired balance in clinical practice for optimal fracture prevention.
Article
Neurosciences
Stefano Scarano, Valeria Ada Sansone, Carola Rita Ferrari Aggradi, Elena Carraro, Luigi Tesio, Maurizio Amadei, Viviana Rota, Alice Zanolini, Antonio Caronni
Summary: This study aimed to explore the pathophysiology of balance impairment in DM1. The results showed that DM1 patients had poorer standing balance compared to controls in various conditions. Muscle weakness was found to be a contributing factor, but not the sole explanation. Patients relied more on vision to maintain balance and impairment of sensory systems also played a role in falls. Rehabilitation programs targeting sensory reweighting could improve the mobility and safety of DM1 patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Bin Liu, Guifeng Zhao, Ling Jin, Jingping Shi
Summary: The severity of WMHs in lacunar infarct patients is associated with age, cognitive decline, and impairment in balance. The track length in the anteroposterior direction with eyes closed may serve as a potential marker for disease progression in WMHs.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Matthew Silsby, Con Yiannikas, Karl Ng, Matthew C. Kiernan, Victor S. C. Fung, Steve Vucic
Summary: Posturography was used to assess balance in CIDP patients receiving IVIg treatment, showing significant improvement in balance. This suggests that posturography can serve as an objective marker of treatment response in clinical management and therapeutic trials.
Editorial Material
Biochemistry & Molecular Biology
Varun Nalam, He (Helen) Huang
Summary: A phase 1 trial demonstrated the potential of improving energy efficiency in walking by combining a powered hip exoskeleton with a passive leg prosthesis.
Article
Rehabilitation
Karlien Mul, Feri Wijayanto, Tom G. J. Loonen, Perry Groot, Sanne C. C. Vincenten, Simone Knuijt, Jan T. Groothuis, Thomas J. J. Maal, Tom Heskes, Nicol C. Voermans, Baziel G. M. van Engelen
Summary: This study developed a functional assessment measure for evaluating the functional disabilities associated with facial weakness in facioscapulohumeral muscular dystrophy (FSHD). The measure demonstrated good reliability and validity, and can be used as a tool for further research.
DISABILITY AND REHABILITATION
(2023)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Rehabilitation
W. A. Van de Geest-Buit, N. B. Rasing, K. Mul, J. C. W. Deenen, S. C. C. Vincenten, I Siemann, A. Lanser, J. T. Groothuis, B. G. van Engelen, J. A. E. Custers, N. C. Voermans
Summary: This study aimed to evaluate the psychosocial outcomes of facial weakness in facioscapulohumeral muscular dystrophy (FSHD). The findings showed that patients reported mild to moderate psychological distress, fear of negative evaluation, and social functioning. However, severe self-reported facial weakness was associated with lower social functioning. Patients with more facial dysfunction experienced higher fear of negative evaluation and lower social functioning. Younger age, presence of pain, fatigue, walking difficulty, and psychological support were also factors contributing to lower psychosocial outcomes. Overall, this study suggests that a multidisciplinary, personalized approach is needed to address the physical, emotional, and social consequences of FSHD.
DISABILITY AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Isis B. T. Joosten, Cheyenne E. W. Janssen, Corinne G. C. Horlings, Dennis den Uijl, Reinder Evertz, Baziel G. M. van Engelen, Catharina G. Faber, Kevin Vernooy
Summary: The study aims to evaluate the clinical effectiveness of routine 24-hour Holter monitoring in screening for conduction disturbances and arrhythmias in patients with myotonic dystrophy type 1 (DM1). The results show that Holter monitoring can detect conduction disorders in the majority of DM1 patients, and a significant proportion of patients experience new arrhythmias during Holter monitoring. Therefore, incorporating 24-hour Holter monitoring into routine cardiac screening is of added value for DM1 patients.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
Amir H. Talebi, Jan H. L. Ypinga, Nienke M. De Vries, Jorik Nonnekes, Marten Munneke, Bas R. Bloem, Tom Heskes, Yoav Ben-Shlomo, Sirwan K. L. Darweesh
Summary: Specialized physiotherapy and occupational therapy can reduce the incidence rate of Parkinson's disease-related complications. There may be a synergistic effect among multiple specialized allied health disciplines. The findings of this study support the introduction of specialized allied health therapy expertise in Parkinson's disease care.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Milan Beckers, Peter J. Koehler, Geert J. A. Wanten, Bastiaan R. Bloem
Summary: There is a hypothesis suggesting that Adolf Hitler had Parkinson's disease and suffered from gastrointestinal symptoms, possibly linked to small-intestinal bacterial overgrowth (SIBO), serving as an early indication of Parkinson's.
EUROPEAN NEUROLOGY
(2023)
Article
Clinical Neurology
Renee Lustenhouwer, Ian G. M. Cameron, Nens van Alfen, Ivan Toni, Alexander C. H. Geurts, Baziel G. M. van Engelen, Jan T. Groothuis, Rick C. Helmich
Summary: This study aimed to determine whether abnormal cerebral sensorimotor representations associated with peripheral nerve damage in neuralgic amyotrophy (NA) can be changed by specialized multidisciplinary outpatient rehabilitation. The results showed that the multidisciplinary rehabilitation group demonstrated significant clinical improvement on the Shoulder Rating Questionnaire, while both groups showed improvement in task performance and increased activity in visuomotor occipito-parietal brain areas specific to the affected upper extremity. This study suggests that abnormal cerebral sensorimotor representations can recover towards normality after peripheral nerve damage.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.