Article
Plant Sciences
Behrooz Khakpour Taleghani, Behnaz Ghaderi, Mohammad Rostampour, Edris Mahdavi Fekjur, Farkhonde Hasannejad, Malek Moien Ansar
Summary: This study found that the extract of CE has potential anti-nociceptive effects, which may be mediated by opioidergic and GABAergic systems.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Mengwei Sun, Ositomiwa O. Osipitan, Ewa K. Sulicz, Anthony J. Di Pasqua
Summary: Many patients have reported that lidocaine injections prior to facial plastic surgeries cause severe pain, and the lidocaine gels and creams currently available cannot provide an equal or better local anesthetic effect. To address this issue, researchers have developed a lidocaine gel formulated with ultraflexible liposomes, which has shown improved skin permeation ability and local analgesic effect.
Article
Chemistry, Medicinal
Tetsuji Noguchi, Yuma Umezaki, Rieko Takano, Teppei Fujimoto, Yuki Domon, Kazufumi Kubota, Kenjiro Ueda, Yumi Kawase, Koichi Yabe, Miki Yokoyama, Kousei Shimada
Summary: DS21980956 is a novel [5.2.1]bicyclic basic compound with potent analgesic activity that does not exhibit agonistic activity at the mu opioid receptor (MOR).
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Multidisciplinary Sciences
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simo, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Summary: The loss of NPC1 function alters the nanoscale distribution and function of ion channels, leading to abnormal calcium entry, mitochondrial dysfunction, and neurotoxicity. These findings provide insights into the molecular mechanisms connecting NPC1 loss to NPC-associated neuropathology.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat, Hasriadi
Summary: This study demonstrates strong antinociceptive synergism between curcumin and piperine in mouse models, with no potential CNS side effects, suggesting its possible use in clinical trials.
Article
Clinical Neurology
Sajad Mazaheri, Morteza Zendehdel, Abbas Haghparast
Summary: This study assessed the role of OX1R and OX2R in stress-induced sensitization to morphine. The results showed that OX1R and OX2R antagonists can block the morphine sensitization induced by concurrent administration of stress and a low dose of morphine.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
Summary: In this study, we investigated the pharmacological properties of LP1 analogs both in vitro and in vivo to develop compounds with improved analgesic effects. By modifying the structure of the N-substituent of LP1, we found that compounds 3 and 7 displayed high binding affinity for the mu opioid receptor (MOR) and showed antagonist or agonist effects in different assays. Compound 7, as potent as LP1 and DAMGO, demonstrated analgesic effects in thermal and inflammatory pain models.
Article
Psychology, Biological
Hossein Khaleghzadeh-Ahangar, Mina Rashvand, Abbas Haghparast
Summary: The study showed that dopamine receptors in the dentate gyrus play a crucial role in pain modulation induced by lateral hypothalamus stimulation, with D2-like receptors having a more prominent effect than D1-like receptors. The findings suggest a complex neural circuitry where antinociceptive effects are produced, in part, via dopamine receptors in the DG region.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Afsaneh Zargarani, Saeideh Karimi-Haghighi, Abbas Haghparast
Summary: The administration of OXRs antagonist in the CA1 impairs the analgesic effects induced by LH chemical stimulation in acute pain models, suggesting a critical role of hippocampal orexinergic system in pain perception.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lina Karrat, Mohammad Yaser Abajy, Ream Nayal
Summary: The study assessed the anti-inflammatory and analgesic effects of Cedrus libani and Pinus brutia leaves, demonstrating both plants' efficacy in reducing inflammation and pain.
Article
Biochemistry & Molecular Biology
Mohammad Saghafi, Elaheh Danesh, Reyhaneh Askari, Zahra Mousavi, Abbas Haghparast
Summary: Several preclinical and clinical studies have shown that acute stress can reduce pain perception and increase pain tolerance, known as stress-induced analgesia (SIA). Dopamine and dopaminergic neurons in the VTA are involved in SIA. This study aimed to investigate the role of VTA dopaminergic receptors in the antinociceptive responses induced by forced swim stress (FSS) in a model of acute pain.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Majid Nami, Peyman Salehi, Morteza Bararjanian, Nazanin Seighal Delshad, Bahareh Heidari, Mona Khoramjouy, Soraya Shahhosseini, Mehrdad Faizi
Summary: A series of novel triazole compounds containing derivatives of norsufentanil were synthesized and evaluated for their affinity and anti-nociceptive activity. Compound 3h exhibited the highest affinity and potency among all the selected compounds.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ahmed Tokhi, Zainab Ahmed, Mehreen Arif, Naeem Ur Rehman, Vahid Sheibani, Robert D. E. Sewell, Khalid Rauf
Summary: This study aimed to investigate the effects of 1-methyl 1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous amine with a known neuroprotective profile, in a model of streptozotocin (STZ) induced diabetic neuropathic pain (DPN). The results showed that 1MeTIQ reversed DPN and restored altered neurotransmitter concentrations in the brain, suggesting its potential in DPN management.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychology, Biological
Parisa Sadat Panahi, Sogol Esmaili, Mohadeseh Ghalandari-Shamami, Zahra Mousavi, Abbas Haghparast
Summary: Studies show that the brain's Orexin system, particularly in the hippocampus's dentate gyrus, plays a crucial role in pain modulation. The present study found that antagonists of Orexin-1 and Orexin-2 receptors in the dentate gyrus region can reduce acute pain caused by forced swim stress.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo A. Cingolani, Agnes Thalhammer, Fanny Jaudon, Jessica Muia, Gabriele Baj
Summary: Using superresolution structured illumination microscopy, we investigated the nanoscale organization of two Ca(V)2.1 splice isoforms at presynaptic terminals. We found that Ca(V)2.1[EFa] is more tightly co-localized with presynaptic markers, indicating that alternative splicing plays a crucial role in the synaptic organization of Ca(V)2.1 channels.
BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Toshihiro Imada, Shigeru Nakamura, Ryuji Hisamura, Yusuke Izuta, Kai Jin, Masataka Ito, Naoki Kitamura, Kenji F. Tanaka, Masaru Mimura, Izumi Shibuya, Kazuo Tsubota
SCIENTIFIC REPORTS
(2017)
Article
Veterinary Sciences
Takuro Yoshimoto, Eiki Takahashi, Shunji Yamashita, Kiichi Ohara, Kimie Niimi
EXPERIMENTAL ANIMALS
(2018)
Article
Neurosciences
Tomomi Shimogori, Ayumi Abe, Yasuhiro Go, Tsutomu Hashikawa, Noriyuki Kishi, Satomi S. Kikuchi, Yoshiaki Kita, Kimie Niimi, Hirozumi Nishibe, Misako Okuno, Kanako Saga, Miyano Sakurai, Masae Sato, Tsuna Serizawa, Sachie Suzuki, Eiki Takahashi, Mami Tanaka, Shoji Tatsumoto, Mitsuhiro Toki, U. Mami, Yan Wang, Karl J. Windak, Haruhiko Yamagishi, Keiko Yamashita, Tomoko Yoda, Aya C. Yoshida, Chihiro Yoshida, Takuro Yoshimoto, Hideyuki Okano
NEUROSCIENCE RESEARCH
(2018)
Article
Multidisciplinary Sciences
Yumi Matsushita, Miki Manabe, Naoki Kitamura, Izumi Shibuya
Article
Medicine, Research & Experimental
Yumi Matsushita, Naoki Kitamura, Masashi Higuchi, Yoshinao Z. Hosaka, Izumi Shibuya
BIOMEDICAL RESEARCH-TOKYO
(2018)
Article
Immunology
Yuko Shigeno, Mutsumi Toyama, Mutsumi Nakamura, Kimie Niimi, Eiki Takahashi, Yoshimi Benno
MICROBIOLOGY AND IMMUNOLOGY
(2018)
Article
Neurosciences
Yu Izumisawa, Keiko Tanaka-Yamamoto, John Ciriello, Naoki Kitamura, Izumi Shibuya
Article
Cell Biology
Tomohiko Kayano, Yuto Sasaki, Naoki Kitamura, Nobuya Harayama, Taiki Moriya, Govindan Dayanithi, Alexei Verkhratsky, Izumi Shibuya
Article
Biochemistry & Molecular Biology
Kimie Niimi, Hiromasa Morishita, Masaya Usui, Reiko Ito, Shino Kurata, Nobuko Mataga, Eiki Takahashi
BIOSCIENCE REPORTS
(2019)
Article
Neurosciences
Yu Izumisawa, Keiko Tanaka-Yamamoto, John Ciriello, Naoki Kitamura, Izumi Shibuya
Article
Multidisciplinary Sciences
Kimie Niimi, Eiki Takahashi
Article
Veterinary Sciences
Katsuhiko Warita, Ryo Aoki, Naoki Kitamura, Izumi Shibuya, Yoshinao Z. Hosaka
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2019)
Article
Veterinary Sciences
Kimie Niimi, Patrick Hardy, Brian Bilecki, Eiki Takahashi
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2019)
Article
Neurosciences
Naoki Kitamura, Erika Nagami, Yumi Matsushita, Tomohiko Kayano, Izumi Shibuya
Article
Veterinary Sciences
Kimie Niimi, Shigeri Maruyama, Norihisa Sako, Kazuyoshi Miyata, Takuro Yoshimoto, Brian Bileckei, Kenneth. S. Henderson, Eiki Takahashi
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2018)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.