Article
Pharmacology & Pharmacy
Shihao Huang, Yu Zhou, Feilong Wu, Cuijie Shi, He Yan, Liangpei Chen, Chang Yang, Yixiao Luo
Summary: This study found that berberine combined with extinction training can effectively promote the extinction of fear memories and prevent their reinstatement and spontaneous recovery. This finding provides a new potential avenue for the treatment of fear-related disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Rachel Ahrenholtz, Jaryd Hiser, Marisa C. Ross, Anthony Privratsky, Anneliis Sartin-Tarm, G. Andrew James, Josh M. Cisler
Summary: The study identified three distinct neurocircuitry biotypes among women with PTSD, each associated with different neurocognitive features and clinical symptoms. This highlights the importance of considering different biotypes in PTSD research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Zhe Yu, Alexandre Kisner, Amy Bhatt, Abigail M. Polter, Paul J. Marvar
Summary: This study examined the role of angiotensin II receptor type 1 (AT1R) neurons in the central amygdala (CeA) in fear and anxiety-related behavior using AT1R transgenic mice. It was found that AT1R+ neurons were localized to GABA expressing neurons in the CeL, and their deletion enhanced extinction learning. Furthermore, the application of angiotensin II increased inhibitory synaptic currents and decreased the excitability of CeL-AT1R+ neurons. These findings provide new insights into the neurobiological mechanisms underlying fear extinction.
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Jeehye Seo, Katelyn Oliver, Carolina Daffre, Kylie N. Moore, Samuel Gazecki, Natasha B. Lasko, Mohammed R. Milad, Edward F. Pace-Schott
Summary: Sleep disturbances may increase the risk of developing posttraumatic stress disorder (PTSD). Different patterns of neural activations during fear extinction may be observed in individuals with PTSD compared to trauma-exposed controls.
Article
Biochemistry & Molecular Biology
Einat Elharrar, Yahav Dikshtein, Sapir Meninger-Mordechay, Yehuda Lichtenstein, Gal Yadid
Summary: Recent research shows that inhibiting PARP-1 activity can interfere with fear conditioning and reduce freezing behavior. By controlling the pharmacokinetic timing, it is possible to specifically disrupt cue-associated fear memories without interfering with other natural memories.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Johannes Kornhuber, Iulia Zoicas
Summary: NPY reduces social fear expression by acting on DLS and CeA, not effective in DH, MeA, and BLA regions. It also exhibits anxiolytic effects when administered in DH, DLS, CeA, and BLA, but not in MeA. This suggests that different neural circuitries are involved in the effects of NPY on social fear expression and anxiety-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiahui Yu, Toshie Naoi, Masanori Sakaguchi
Summary: Fear generalization is a symptom of anxiety-related disorders, as demonstrated in mice exposed to similar neutral contexts after fear conditioning. This study provides insight into factors influencing fear generalization and may aid future research into the pathophysiological mechanisms of anxiety-related disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Malgorzata Lehner, Anna Skorzewska, Aleksandra Wislowska-Stanek
Summary: Post-traumatic stress disorder (PTSD) is a condition that involves repeated experiences of traumatic events, avoidance, negative changes in cognition and mood, hyperarousal, and severe impairment in functioning. Women are twice as likely as men to develop PTSD, and this sex-specific predisposition may be related to differences in the functioning of stress-responsive systems influenced by gonadal hormones and stress peptides. Estrogen levels play a role in the risk of developing or exacerbating PTSD, and there are genetic factors, such as estrogen response elements, that contribute to sex differences in corticotropin-releasing factor (CRF) function. It has been found that fear extinction, which is important for the effectiveness of behavioral therapy for PTSD, is more effective in women during periods of high estrogen levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Johannes Kornhuber, Iulia Zoicas
Summary: This study demonstrates that NPY reduces expression of social fear in the DLS via Y2 receptors while in the CeA it acts through Y1 receptors, suggesting differential recruitment of receptor subtypes in these brain regions to mediate the effects of NPY on social fear expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Khadijah Shanazz, Rachael Dixon-Melvin, Rebecca Nalloor, Riya Thumar, Almira I. Vazdarjanova
Summary: According to animal experiments, there are differences in the expression of fear memories between female and male rats. Female rats tend to express fear memories through active motor responses, which is referred to as "Anxioescapic" behavior strategy. There is no significant difference in fear learning between female and male rats.
Article
Behavioral Sciences
Itamar Lerner, Shira M. Lupkin, Alan Tsai, Anosha Khawaja, Mark A. Gluck
Summary: REM sleep plays a crucial role in modulating fear memories consolidation, impacting the development of PTSD. The findings suggest that REM sleep impairs recall of original threat memories but enhances the ability to generalize these memories in novel situations.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Gary B. Kaplan, Gabrielle A. Lakis, Hryhoriy Zhoba
Summary: This review emphasizes the significance of the orexin neural system in the pathophysiology of PTSD. Orexinergic neurons play a crucial role in fear behaviors, sleep disturbances, and stress responses. Activation of the orexin system is associated with increased fear expression, impaired sleep, and heightened stress.
BRAIN RESEARCH BULLETIN
(2022)
Review
Neurosciences
Jeffrey B. Rosen, Jay Schulkin
Summary: This study suggests that hyperexcitability in fear circuits plays a crucial role in the development of pathological anxiety and trauma. The hyperexcitability is proposed to be caused by acquired sensitization in fear circuits, which progressively worsens over time and results in changing symptoms during early and late pathology.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Allison M. Letkiewicz, Amy L. Cochran, Anthony A. Privratsky, G. Andrew James, Josh M. Cisler
Summary: By utilizing computational modeling to analyze skin conductance responses during fear acquisition, the study found evidence of disrupted model-based reinforcement learning processes in women with interpersonal violence (IPV)-related PTSD, which may contribute to impaired fear and safety learning, and could potentially be related to treatment response.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Charles L. Pickens, Hayley Fisher, Nicholas Bright, Mark Gallo, Madelyn H. Ray, Antje Anji, Meena Kumari
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Mikko Airavaara, Charles L. Pickens, Anna L. Stern, Kristina A. Wihbey, Brandon K. Harvey, Jennifer M. Bossert, Qing-Rong Liu, Barry J. Hoffer, Yavin Shaham
Article
Behavioral Sciences
Charles L. Pickens, Florence R. Theberge
BEHAVIOURAL PHARMACOLOGY
(2014)
Article
Neurosciences
Nathan J. Marchant, Thi N. Khuc, Charles L. Pickens, Antonello Bonci, Yavin Shaham
BIOLOGICAL PSYCHIATRY
(2013)
Article
Neurosciences
Florence R. Theberge, Xuan Li, Santa Kambhampati, Charles L. Pickens, Robyn St. Laurent, Jennifer M. Bossert, Michael H. Baumann, Mark R. Hutchinson, Kenner C. Rice, Linda R. Watkins, Yavin Shaham
BIOLOGICAL PSYCHIATRY
(2013)
Article
Neurosciences
Jianfeng Liu, Liyan Zhao, Yanxue Xue, Jie Shi, Lin Suo, Yixiao Luo, Baisheng Chai, Chang Yang, Qin Fang, Yan Zhang, Yanping Bao, Charles L. Pickens, Lin Lu
BIOLOGICAL PSYCHIATRY
(2014)
Editorial Material
Neurosciences
Charles L. Pickens, Donna J. Calu
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Sunila G. Nair, Brittany M. Navarre, Carlo Cifani, Charles L. Pickens, Jennifer M. Bossert, Yavin Shaham
NEUROPSYCHOPHARMACOLOGY
(2011)
Article
Multidisciplinary Sciences
Lauren DePoy, Rachel Daut, Jonathan L. Brigman, Kathryn MacPherson, Nicole Crowley, Ozge Gunduz-Cinar, Charles L. Pickens, Resat Cinar, Lisa M. Saksida, George Kunos, David M. Lovinger, Timothy J. Bussey, Marguerite C. Camp, Andrew Holmes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Neurosciences
Jesse R. Schank, Charles L. Pickens, Kelly E. Rowe, Kejun Cheng, Annika Thorsell, Kenner C. Rice, Yavin Shaham, Markus Heilig
PSYCHOPHARMACOLOGY
(2011)
Article
Neurosciences
Charles L. Pickens, Carlo Cifani, Brittany M. Navarre, Hila Eichenbaum, Florence R. Theberge, Michael H. Baumann, Donna J. Calu, Yavin Shaham
PSYCHOPHARMACOLOGY
(2012)
Article
Neurosciences
Florence R. M. Theberge, Charles L. Pickens, Evan Goldart, Sanya Fanous, Bruce T. Hope, Qing-Rong Liu, Yavin Shaham
PSYCHOPHARMACOLOGY
(2012)
Review
Neurosciences
Charles L. Pickens, Mikko Airavaara, Florence Theberge, Sanya Fanous, Bruce T. Hope, Yavin Shaham
TRENDS IN NEUROSCIENCES
(2011)
Article
Behavioral Sciences
Hayley Fisher, Nicholas Bright, Mark Gallo, Alisa Pajser, Charles L. Pickens
BEHAVIOURAL PHARMACOLOGY
(2017)
Article
Behavioral Sciences
Charles L. Pickens, Lexia Aurand, Joshua Hunt, Hayley Fisher
BEHAVIOURAL PHARMACOLOGY
(2017)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.