Article
Neurosciences
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Summary: This study evaluated the effects of thrombin pathway inhibition in a mice model of SE and found that thrombin is involved in memory impairment and cognitive dysfunction. Inhibiting the thrombin pathway can prevent cognitive impairment and reduce neuronal damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Marek Pawlik, Anna Maria Czarnecka, Marcin Kolodziej, Katarzyna Skowronska, Michal Wegrzynowicz, Martyna Podgajna, Stanislaw Jerzy Czuczwar, Jan Albrecht
Summary: This study found that pretreatment with a glutamine synthetase inhibitor, methionine sulfoximine (MSO), can mitigate the intensity of seizures during the initial phase. The protective effect of MSO is achieved by preventing an increase in cell volume.
Article
Neurosciences
Maxime Levesque, Siyan Wang, Guillaume Etter, Sylvain Williams, Massimo Avoli
Summary: Bilateral activation of PV interneurons in the hippocampus promotes seizures and high-frequency oscillations in a mouse model of mesial temporal lobe epilepsy.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Sebastian Meller, Christopher Kaeufer, Bjoern Gailus, Claudia Brandt, Wolfgang Loescher
Summary: Prevention or modification of acquired epilepsy in patients at risk is an urgent, yet unmet, clinical need. Treatment with the muscarinic antagonist scopolamine during the latent period after SE may help prevent or modify epilepsy and associated behavioral and cognitive alterations in female Sprague-Dawley rats, as indicated by reduced seizure incidence and behavioral excitability. Future studies are needed to further investigate the antiepileptogenic/disease-modifying activity of scopolamine in the lithium-pilocarpine rat model.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Olga E. Zubareva, Denis S. Sinyak, Alisa D. Kalita, Alexandra V. Griflyuk, Georgy P. Diespirov, Tatiana Y. Postnikova, Aleksey V. Zaitsev
Summary: This study evaluated the effects of anakinra, lamotrigine, and their combination on epileptogenesis using a rat model. The treatment showed significant reductions in the severity of seizures and neuronal loss in the CA1 hippocampus. However, the combination treatment was less effective in preventing neuron loss in the hippocampal CA3 field compared to monotherapy. The findings suggest that anakinra and lamotrigine, either alone or in combination, may be clinically useful in preventing histopathological and behavioral abnormalities associated with epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Plinio C. Casarotto, Mykhailo Girych, Senem M. Fred, Vera Kovaleva, Rafael Moliner, Giray Enkavi, Caroline Biojone, Cecilia Cannarozzo, Madhusmita Pryiadrashini Sahu, Katja Kaurinkoski, Cecilia A. Brunello, Anna Steinzeig, Frederike Winkel, Sudarshan Patil, Stefan Vestring, Tsvetan Serchov, Cassiano R. A. F. Diniz, Liina Laukkanen, Iseline Cardon, Hanna Antila, Tomasz Rog, Timo Petteri Piepponen, Clive R. Bramham, Claus Normann, Sari E. Lauri, Mart Saarma, Ilpo Vattulainen, Eero Castren
Summary: The study reveals that antidepressant drugs bind directly to the TRKB receptor, facilitating its activation at the synapse and potentially explaining the mechanism behind antidepressant action.
Article
Multidisciplinary Sciences
Nicholas D. Henkel, Marissa A. Smail, Xiaojun Wu, Heather A. Enright, Nicholas Fischer, Hunter M. Eby, Robert E. McCullumsmith, Rammohan Shukla
Summary: The study identified 119 genes associated with epilepsy and revealed their impact on homeostatic and synaptic pathways. Analysis of cellular proportions showed opposing changes in different cell types. A Bayesian network analysis demonstrated aberrant physiological interactions between nonneuronal cells and Vip interneurons in driving seizures.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
F. A. Concepcion, N. A. Ekstrom, M. N. Khan O. O. Estes, N. P. Poolos
Summary: This study investigated the expression and phosphorylation of the intracellular protein Tau in a rat model of temporal lobe epilepsy. The results showed that although Tau expression levels had a modest reduction at two months post-seizure, they had returned to normal by four months. However, there was a significant decrease in phosphorylation levels at the S202/T205 locus. These findings suggest that Tau may play a different role in epilepsy compared to Alzheimer's disease.
Article
Multidisciplinary Sciences
Chen Zhang, Zixian He, Zheren Tan, Fafa Tian
Summary: Silencing of DG in the PTZ kindling rat model of TLE can modulate MFS and epileptogenesis through NDR2, leading to a possible strategy for preventing epileptogenesis.
Article
Biochemistry & Molecular Biology
Michaela Shishmanova-Doseva, Dimitrinka Atanasova, Yordanka Uzunova, Lyubka Yoanidu, Lyudmil Peychev, Pencho Marinov, Jana Tchekalarova
Summary: In a model of TLE, chronic treatment with Lacosamide (LCM) reduced the number of spontaneous motor seizures, corrected the impact of comorbidities on motor activity, anxiety, and memory, and suppressed oxidative stress by increasing superoxide dismutase activity and glutathione levels while decreasing catalase activity and lipid peroxidation in the hippocampus. Additionally, LCM treatment mitigated neuroinflammation and exerted strong neuroprotection in key regions of the brain, suggesting its antioxidant, anti-inflammatory, and neuroprotective properties contribute to its anticonvulsant and beneficial effects on SE-induced behavioral comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqiang Xiao, Fangyi Ling, Chong-Bo Chen, Jiajian Liang, Yingjie Cao, Yanxuan Xu, Haoyu Chen
Summary: This study aims to investigate the co-expression and interaction of PRPF31 and PRPH2. Through transfection and immunological experiments, it was found that they co-localize and interact in cells and mouse retina.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Youtong Huang, Greg Lemke
Summary: Recurrent seizures, which may contribute to the pathogenesis and cognitive decline of Alzheimer's disease, are common in early-stage AD and mouse models that overproduce amyloid beta. In a study of the APP/PS1 mouse model, it was found that the mutation of TAM receptor tyrosine kinase (RTK) Mer or its ligand Gas6 significantly increased the risk of early death, which was tied to violent seizures originating in the dentate gyrus of the hippocampus. TAM-deficient mice showed increased newborn DG neurons and excitatory synapses, coinciding with premature death and adult neurogenesis. In contrast, the incidence of lethal seizures was strongly anticorrelated with the deposition of dense-core amyloid plaques. These findings suggest that TAM-mediated phagocytosis influences synaptic connectivity in the hippocampus and that seizure-inducing amyloid beta polymers are present before the formation of dense-core plaques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Nishtha Agnihotri, M. Hasan Mohajeri
Summary: This report systematically reviews preclinical rodent reports on the connection between the composition of the intestinal microbiota and neurogenesis and neurotrophins in the hippocampus. The findings suggest both positive and negative correlations between the microbiota composition and neurogenesis or BDNF expression. Age, SCFA, obesity, and chronic stress are identified as recurring factors in these studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mahnaz Mansouri, Leopold Kremser, Thanh-Phuong Nguyen, Yu Kasugai, Laura Caberlotto, Martin Gassmann, Bettina Sarg, Herbert Lindner, Bernhard Bettler, Lucia Carboni, Francesco Ferraguti
Summary: In this study, novel protein complexes associated with mGlu(1) in the mouse cerebellum were identified using co-immunoprecipitation and mass spectrometry analysis. The study also discovered a potential interacting protein, KCTD12, and determined that the interaction between KCTD12 and mGlu(1) is mediated through interposed proteins.
Article
Neurosciences
Hemant Kumar, Jatinder Katyal, Yogendra Kumar Gupta
Summary: This study demonstrates the therapeutic effects of the KOR agonist U50488 on SE and its beneficial effects on SE-related mortality and memory impairment in a rat lithium-pilocarpine SE model.
NEUROSCIENCE LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Juan Pablo Zanin, Nicolas Unsain, Agustin Anastasia
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Katsuhiro Takeda, Pouneh Kermani, Agustin Anastasia, Yusuke Obinata, Barbara L. Hempstead, Hidemi Kurihara
BIOCHEMISTRY AND CELL BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Agustin Anastasia, Luciana Torre, Gabriel A. de Erausquin, Daniel H. Masco
JOURNAL OF NEUROCHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Adrianna Kalous, Matthew R. Nangle, Agustin Anastasia, Barbara L. Hempstead, Janet R. Keast
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Neurosciences
Bruno A. Benitez, Helen M. Belalcazar, Agustin Anastasia, Daniel T. Mamah, Charles F. Zorumski, Daniel H. Masco, Daniel G. Herrera, Gabriel A. de Erausquin
Article
Neurosciences
A. Anastasia, J. Wojnacki, G. A. de Erausquin, D. H. Masco
Article
Multidisciplinary Sciences
Hector Alejandro Guidobaldi, Maria Eugenia Teves, Diego Rafael Unates, Agustin Anastasia, Laura Cecilia Giojalas
Article
Multidisciplinary Sciences
Agustin Anastasia, Katrin Deinhardt, Shiyang Wang, Laura Martin, Donna Nichol, Krithi Irmady, Jasmine Trinh, Luis Parada, Shahin Rafii, Barbara L. Hempstead, Pouneh Kermani
Article
Multidisciplinary Sciences
Agustin Anastasia, Katrin Deinhardt, Moses V. Chao, Nathan E. Will, Krithi Irmady, Francis S. Lee, Barbara L. Hempstead, Clay Bracken
NATURE COMMUNICATIONS
(2013)
Article
Nutrition & Dietetics
Cintia Y. Porcari, Agustina Macagno, Andre S. Mecawi, Agustin Anastasia, Ximena E. Caeiro, Andrea Godino
Summary: Cardiovascular control is affected by high sodium consumption during the perinatal period, leading to anatomical and molecular changes in the kidney, brain, and blood vessels that increase blood pressure. The programming effects of perinatal sodium consumption on blood pressure control have not been fully understood.
Article
Cell Biology
Paula Virginia Subirada, Albana Tovo, Maria Victoria Vaglienti, Jose Domingo Luna Pinto, Horacio Uri Saragovi, Maria Cecilia Sanchez, Agustin Anastasia, Pablo Federico Barcelona
Summary: Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration. Mononuclear phagocytic cells (MPCs) are recruited and activated through p75 neurotrophin receptor (p75(NTR)) in a mouse model of laser-induced CNV, contributing to CNV pathology. Knockout of p75(NTR) or treatment with its antagonist reduces MPC recruitment, glial activation, CNV area, and preserves retinal function in mice with CNV.
Article
Biochemistry & Molecular Biology
Agustin Anastasia, Gabriel A. de Erausquin, Jose Wojnacki, Daniel H. Masco
JOURNAL OF NEUROCHEMISTRY
(2007)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.