Article
Neurosciences
Giulio Matteucci, Maelle Guyoton, Johannes M. Mayrhofer, Matthieu Auffret, Georgios Foustoukos, Carl C. H. Petersen, Sami El-Boustani
Summary: Behavioral states have an impact on the performance and learning of sensorimotor tasks, and this is related to altered neuronal sensory representations. In a study using water-restricted mice, it was found that cortical circuits and state-dependent sensory processing changes play a role in perceptual decision-making.
Article
Neurosciences
Jan Antoni Jablonka, Robert Binkowski, Marcin Kazmierczak, Maria Sadowska, Wladyslaw Sredniawa, Aleksandra Szlachcic, Paulina Urban
Summary: Research shows that cortical map remodeling induced by experience-dependent plasticity mechanisms is partially dependent on the contralateral hemisphere. This suggests that plastic changes in one hemisphere can influence the functioning of the opposite hemisphere.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth, Sergiu P. Pasca
Summary: This study demonstrates the potential of transplanting self-organizing neural organoids derived from human stem cells into the somatosensory cortex of rats to develop mature cell types and integrate into sensory and motivation-related circuits. The transplanted cortical neurons exhibit more complex properties than their in vitro counterparts and can drive reward-seeking behavior when optogenetically activated. This approach has the potential to detect circuit-level phenotypes in patient-derived cells that cannot be uncovered using other methods.
Article
Multidisciplinary Sciences
Yael Oran, Yonatan Katz, Michael Sokoletsky, Katayun Cohen-Kashi Malina, Ilan Lampl
Summary: In awake mice, interhemispheric correlations between the barrel cortices are reduced during whisking due to lower callosal activity.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Klas Kullander, Lisa Topolnik
Summary: The passage discusses the concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, and the different subtypes of GABAergic inhibitory interneurons in cortical circuits. It highlights the central role of a subpopulation of GABAergic cells expressing VIP in disinhibitory modulation, as well as the multiple layers of disinhibition across cortical circuits regulating behavior and maintaining an excitation/inhibition balance.
TRENDS IN NEUROSCIENCES
(2021)
Article
Multidisciplinary Sciences
Alberto Lazari, Piergiorgio Salvan, Lennart Verhagen, Michiel Cottaar, Daniel Papp, Olof Jens van der Werf, Bronwyn Gavine, James Kolasinski, Matthew Webster, Charlotte J. Stagg, Matthew F. S. Rushworth, Heidi Johansen-Berg
Summary: Myelination levels in white matter tracts may influence the cortico-cortical interactions during tasks, and there is a link between the physiology of the motor network and the myelination of tracts connecting its components. Myelination plays a key role in brain function and can affect motor network physiology.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Jeremy A. Taylor, Zachary Z. Smith, Daniel S. Barth
Summary: By simultaneously mapping SWDs in the rat cerebrum, the researchers discovered that they reflect systematic activation of the facial representation of the somatosensory cortex. SWDs form mirror spatiotemporal patterns in both hemispheres that are precisely aligned in both space and time. This suggests that SWDs may reflect a substrate by which large neural ensembles perform precise spatiotemporal processing of rapidly changing somatosensory input.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vahid Esmaeili, Anastasiia Oryshchuk, Reza Asri, Keita Tamura, Georgios Foustoukos, Yanqi Liu, Romain Guiet, Sylvain Crochet, Carl C. H. Petersen
Summary: This study explores the changes in the activity of excitatory and inhibitory neurons in the mouse sensorimotor cortex before and after learning a whisker detection task. The results indicate that the changes in whisker-evoked activity of these neurons differ in primary and secondary whisker motor cortices, but show similar patterns in primary and secondary orofacial motor cortices. These findings suggest that the balance of excitation and inhibition in local circuits, along with changes in long-range synaptic inputs, may contribute to the performance of delayed sensory-to-motor transformation.
Article
Multidisciplinary Sciences
Arun Parajuli, Diego Gutnisky, Nitin Tandon, Valentin Dragoi
Summary: The state of cortical activity can have both facilitatory and suppressive effects on perceptual performance, depending on the type of task. Contrary to previous beliefs, this study shows that synchronized activity can enhance performance in a detection task but impair it in a discrimination task. These findings suggest that the brain adapts to utilize endogenous fluctuations in neural populations to selectively enhance different sensory processing modes during perception.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Richy Yun, Andrew R. Bogaard, Andrew G. Richardson, Stavros Zanos, Steve I. Perlmutter, Eberhard E. Fetz
Summary: Cortical stimulation can cause excitability changes in both hemispheres, showing potential for clinical rehabilitation of motor function. The effects of delivering CS during different phases of contralateral and ipsilateral limb movement were investigated, with results suggesting that changes in interhemispheric coherence may be indicative of interhemispheric communication.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Stephane Bugeon, Joshua Duffield, Mario Dipoppa, Anne Ritoux, Isabelle Prankerd, Dimitris Nicoloutsopoulos, David Orme, Maxwell Shinn, Han Peng, Hamish Forrest, Aiste Viduolyte, Charu Bai Reddy, Yoh Isogai, Matteo Carandini, Kenneth D. Harris
Summary: This study reveals that inhibitory subtypes in the primary visual cortex exhibit diverse correlates with brain state. These subtypes' activity patterns are organized by the main axis of transcriptomic variation. Different subtypes show significant differences in response to visual stimuli, as well as modulation by brain state. These findings highlight the importance of inhibitory neurons in cortical processing.
Article
Multidisciplinary Sciences
Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura
Summary: Astrocyte activity modulation can drive synaptic remodeling in the cortex, providing a potential therapeutic approach for chronic pain. By combining peripheral nerve block and astrocyte activation, the authors successfully reversed allodynia-like behavior induced by nerve injury in mice, demonstrating a translational approach for pain modulation.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Daniel Udvary, Philipp Harth, Jakob H. Macke, Hans-Christian Hege, Christiaan P. J. de Kock, Bert Sakmann, Marcel Oberlaender
Summary: The wiring specificity in the cerebral cortex is not only determined by synapse formation mechanisms, but also by the morphological properties of the neurons. The morphologically determined wiring specificity is reflected in the axo-dendritic projection patterns, packing density, and cellular diversity of the neurons. These factors determine whether the network topology is recurrent or feedforward.
Article
Neurosciences
Luis E. Martinetti, Kelly E. Bonekamp, Dawn M. Autio, Hye-Hyun Kim, Shane R. Crandall
Summary: Short-term plasticity plays a crucial role in regulating the strength of central synapses based on previous activity. This study investigates the connections between mouse primary somatosensory and motor cortex using an optogenetic approach. It reveals that corticocortical synapses exhibit strong short-term facilitation, leading to more sustained responses compared to local intracortical and thalamocortical connections. The properties of these connections suggest their specialization in conveying information over extended periods.
Article
Biology
Xu-Hui Li, Wantong Shi, Qi-Yu Chen, Shun Hao, Hui-Hui Miao, Zhuang Miao, Fang Xu, Guo-Qiang Bi, Min Zhuo
Summary: The study investigates the cortical-cortical connection between the bilateral anterior cingulate cortex (ACC) and its functional importance. It finds a direct synaptic projection from one side ACC to the contralateral ACC and identifies glutamate as the major excitatory transmitter for this bilateral ACC connection. The activation of this connection enhances pain perception and anxiety-like behaviors associated with acute and chronic pain, while inhibition of the connection reduces hyperalgesia. The findings provide therapeutic targets for the treatment of chronic pain and related emotional disorders.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Arslan Arshad, Linnea R. Vose, Govindaiah Vinukonda, Furong Hu, Kazuaki Yoshikawa, Anna Csiszar, Joshua C. Brumberg, Praveen Ballabh
Article
Neurosciences
Chia-Chien Chen, Philip Chu, Joshua C. Brumberg
NEUROSCIENCE LETTERS
(2015)
Article
Neurosciences
Adesh Bajnath, Philip Chu, Robert Steger, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2015)
Article
Neurosciences
Anjali Gour, Evan H. Lyall, Alexander Naka, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2016)
Article
Neurosciences
Mathew H. Evans, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2017)
Article
Neurosciences
Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalia De Marco Garcia, Joshua C. Brumberg
Article
Neurosciences
Hyeyoung Shin, Malamati Bitzidou, Fernando Palaguachi, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2018)
Article
Neurosciences
Robert Steger, Lauren Blachorsky, Qizong Yang, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2018)
Article
Neurosciences
John Kalambogias, Chia-Chien Chen, Safraz Khan, Titus Son, Racheli Wercberger, Carolyn Headlam, Cindy Lin, Joshua C. Brumberg
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Giuseppe Cataldo, Chia-Chien Chen, Alicia C. Barrientos, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2020)
Review
Neurosciences
Chia-Chien Chen, Joshua C. Brumberg
Summary: Cellular structures form the foundation of the nervous system's functionality. Development can be influenced by external factors, with sensory experiences during critical periods impacting information processing in the brain and subsequently affecting behavior and cognition. Studying sensory experience alterations using the rodent whisker-to-barrel system model helps in understanding how structural plasticity in the brain allows for an integrated view of its functioning.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Fernando Messore, Giuseppe Cataldo, Sarah Lutchman, Alicia Barrientos, Michael Mykins, Felipe Yanez, Joshua C. Brumberg
Summary: This article summarizes the state of research in the whisker-to-barrel sensorimotor system based on presentations at the Barrels meeting. The meeting focused on advanced imaging techniques, the role of microglia, neocortical layer I, neural control of navigation and locomotion, and the utility of psychedelic drugs in perception studies.
SOMATOSENSORY AND MOTOR RESEARCH
(2022)
Article
Neurosciences
Michael Mykins, Krista Marrero, Giuseppe Cataldo, Krithiga Aruljothi, Keerthi Krishnan, Joshua C. C. Brumberg
Summary: The Barrels Meeting, which had been held virtually for two years, returned to an in-person format in La Jolla, California on November 10 and 11, 2022. The focus of the meeting was on the rodent sensorimotor system, specifically the integration of information from the cellular to the systems level. The presentations and poster session discussed the latest findings in the whisker-to-barrel pathway, including the encoding of peripheral information, motor planning, and its relevance to neurodevelopmental disorders.
SOMATOSENSORY AND MOTOR RESEARCH
(2023)
Article
Neurosciences
Alicia C. Barrientos, Giuseppe Cataldo, Joshua C. Brumberg
SOMATOSENSORY AND MOTOR RESEARCH
(2019)
Article
Multidisciplinary Sciences
Philip Chu, Eric Chen, Adesh Bajnath, Joshua C. Brumberg
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
