Article
Biotechnology & Applied Microbiology
Sisi Mi, Xue Wang, Jiaxin Gao, Yu Liu, Zhongquan Qi
Summary: After spinal cord injury (SCI), the microenvironment inhibits neural regeneration due to the abundance of inhibitory factors and lack of factors promoting nerve regeneration. This study developed a bioactive material, hp-SHED sheet, to mimic the natural spinal cord structure and enhance nerve cell attachment and migration. Implantation of hp-SHED sheet in SCI rats promoted nerve regeneration, axonal remyelination, and inhibited glial scarring, leading to the restoration of sensory and motor functions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Behavioral Sciences
Wouter A. J. Vints, Oron Levin, Nerijus Masiulis, Jeanine Verbunt, Charlotte C. M. van Laake-Geelen
Summary: Individuals with spinal cord injury (SCI) may experience accelerated cognitive aging, and myokines released during exercise may improve brain health and cognition. However, there is currently a lack of research on the effects of myokines on cognitive function in individuals with SCI, indicating a need for further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Sisi Mi, Zhuo Chang, Xue Wang, Jiaxin Gao, Yu Liu, Wenjia Liu, Wangxiao He, Zhongquan Qi
Summary: Spinal cord injury (SCI) is a severe injury of the central nervous system, causing functional dysfunction and paralysis in millions of patients. A bioactive scaffold, called a spinal cord assembly (SCA), was created using cell-sheet technology and stem cells. This scaffold released neurotrophic exosomes, promoting neuronal regeneration, axonal extension, angiogenesis, and inhibiting glial scar formation in a SCI rat model.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Neurosciences
Margo Randelman, Lyandysha V. Zholudeva, Stephane Vinit, Michael A. Lane
Summary: This article reviews the anatomical incompleteness and neuroplasticity resulting from spinal cord injuries, as well as how non-invasive respiratory treatments can enhance recovery. It focuses on current clinically used respiratory training strategies and those in development, while also considering the impact of training on non-respiratory networks. Insights are given on advances in pre-clinical and translational research in this area, with a look into future directions for enhancing plasticity and improving functional outcomes after SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Petr Krupa, Ahad M. Siddiqui, Peter J. Grahn, Riazul Islam, Bingkun K. Chen, Nicolas N. Madigan, Anthony J. Windebank, Igor A. Lavrov
Summary: Evidence suggests that neuromodulation technologies can facilitate the sublesional spinal networks after spinal cord injury (SCI) by reestablishing excitability and enabling motor signals via residual connections. This review evaluates the evidence of translesional spinal circuit formation and reorganization after SCI, particularly in the presence of sensory inputs during motor training. The potential mechanisms underlying translesional circuitry reorganization during neuromodulation and rehabilitation are discussed, along with the implications for future development of neuromodulation, rehabilitation, and neuroprosthetics technologies.
Article
Engineering, Biomedical
Jin Yan, Liqiang Zhang, Liya Li, Wangxiao He, Wenjia Liu
Summary: The emerging tissue-engineered bio-assemblies are revolutionizing regenerative medicine by providing a potential program to support the clinical translation of stem-cell-derived treatments. By using a developmentally engineered strategy, mesenchymal stem cells (MSC) can be assembled into a bio-assembly called Spinor, which promotes the treatment of spinal cord injury by promoting axonal regeneration and supporting the neuroplasticity of the spinal cord in vivo.
MATERIALS TODAY BIO
(2022)
Article
Neurosciences
Jadwiga N. Bilchak, Kyle Yeakle, Guillaume Caron, Dillon Malloy, Marie-Pascale Cote
Summary: Increasing KCC2 activity to restore chloride homeostasis and endogenous inhibition is an effective approach to reduce spastic symptoms in individuals with SCI, potentially avoiding severe side effects and improving quality of life.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Marcel Simis, Deniz Doruk Camsari, Marta Imamura, Thais Raquel Martins Filippo, Daniel Rubio De Souza, Linamara Rizzo Battistella, Felipe Fregni
Summary: Functional changes after SCI are linked to cortical plasticity, which can be measured by EEG and used as a clinical biomarker. In a study with participants undergoing RAGT, high beta EEG activity negatively correlated with gait and balance at baseline, while improvement in gait and balance correlated with changes in alpha/theta ratio. These findings suggest that EEG may serve as a potential surrogate marker for functional improvement during SCI rehabilitation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Erik Leemhuis, Francesca Favieri, Giuseppe Forte, Mariella Pazzaglia
Summary: This review article provides an overview of the latest interventions for the treatment of spinal cord injury (SCI), including rehabilitation, neuromodulation, and virtual reality applications. Combining existing resources has the potential to improve the short to medium-term living conditions of patients.
Article
Neurosciences
Renaud Jeffrey-Gauthier, Julien Bouyer, Mathieu Piche, Marie-Pascale Cote, Hugues Leblond
Summary: This study found that musculoskeletal injury may hinder locomotor recovery after SCI, with involvement of microglia in this effect, but without modulation of KCC2 expression.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Syed Faraz Kazim, Christian A. Bowers, Chad D. Cole, Samantha Varela, Zafar Karimov, Erick Martinez, Jonathan Ogulnick, Meic H. Schmidt
Summary: Spinal cord injury is a devastating condition affecting millions worldwide. While axonal regeneration in the adult CNS is limited, there is evidence of spontaneous neural reorganization and plasticity in the corticospinal motor circuitry, showing promise for functional recovery after SCI. Various therapeutic approaches, including neuromodulation and rehabilitative training, have been used to harness this neuroplasticity for improved outcomes in both animal models and clinical studies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Engineering, Biomedical
Fatma Inanici, Lorie N. Brighton, Soshi Samejima, Christoph P. Hofstetter, Chet T. Moritz
Summary: Upper extremity paralysis post spinal cord injury greatly impacts independence and quality of life. Non-invasive transcutaneous electrical stimulation shows promising results in rapidly and sustainably restoring hand and arm function, reducing muscle spasticity, and improving autonomic functions. Long-term neuroplasticity may play a role in maintaining functional recovery beyond the stimulation period.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Grazia Maugeri, Alessandra Amato, Martina Sortino, Velia D'Agata, Giuseppe Musumeci
Summary: Spinal cord injury (SCI) leads to sensory and motor function loss. The pathophysiology of SCI involves primary and secondary phases, with oxidative stress playing a significant role in the secondary phase. Exercise is crucial for promoting well-being and quality of life, impacting various systems and potentially regulating the balance between pro-oxidants and antioxidants. This review aims to investigate the effects of exercise on oxidative stress in individuals with SCI, following an overview of spinal cord anatomy and different types of injury.
Article
Pharmacology & Pharmacy
Ravena P. do Nascimento, Livia B. de Jesus, Markley S. Oliveira-Junior, Aurea M. Almeida, Eduardo L. T. Moreira, Bruno D. Paredes, Jorge M. David, Bruno S. F. Souza, Maria de Fatima D. Costa, Arthur M. Butt, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The study found that Agathisflavone can protect injured spinal cord tissue and exhibit therapeutic effects in a rat model of acute spinal cord injury. It also promotes neurogenesis and increases the expression of neurotrophins while reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Milap S. Sandhu, William Z. Rymer
Summary: Acute intermittent hypoxia (AIH) is emerging as a potential intervention to improve breathing and enhance strength and endurance, with the effects showing rapid emergence and prolonged duration. Further research is needed to confirm the therapeutic effects of AIH in clinical settings for promoting recovery and rehabilitation after neurological injuries.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.