Article
Multidisciplinary Sciences
Andrea Brenna, Juergen A. Ripperger, Gabriella Saro, Dominique A. Glauser, Zhihong Yang, Urs Albrecht
Summary: Light influences various physiological processes in mammals, and PER2 has been identified as a co-factor of CREB to facilitate the formation of a transactivation complex on the Per1 gene regulatory region in response to light stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Deborah A. M. Joye, Kayla E. Rohr, Kimberlee Suenkens, Alissa Wuorinen, Thomas Inda, Madeline Arzbecker, Emma Mueller, Alec Huber, Harshida Pancholi, Murray G. Blackmore, Vania Carmona-Alcocer, Jennifer A. Evans
Summary: Daily and annual changes in light are processed by central clock circuits. The role of somatostatin (SST) in the response of the suprachiasmatic nucleus (SCN) to light has not been examined. Our study shows that SST signaling regulates daily rhythms in behavior and SCN function, with sex-specific effects. Lack of SST signaling increases circadian plasticity and eliminates sex differences in photic responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Somaye Mesgar, Seyed Behnamedin Jameie, Abbas Aliaghaei, Siavash Parvardeh, Abolfazl Torabi, Abbas Haghparast
Summary: The study investigated the effects of dopamine D1 agonist on clock gene expressions and behavioral activities in adult male Wistar rats, showing that the agonist increased Per2 and CLOCK expressions during daytime but decreased Per1 and Bmal1 expressions. Moreover, the dopamine D1 agonist only increased Per2 expression significantly during nighttime and decreased Per1, CLOCK, and Bmal1 expressions. Overall, these findings suggest that exogenous dopamine administration can alter clock gene expressions and behavioral activities in rats.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Arthur H. Cheng, Samuel W. Fung, Sara Hegazi, Osama Hasan Mustafa Hasan Abdalla, Hai-Ying Mary Cheng
Summary: The hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, and the transcription factor Sox2 plays a crucial role in controlling the expression of circadian neuropeptides and transcription factors in the embryonic SCN. Sox2 deficiency leads to reduced survival of SCN neurons during the postnatal period, but does not affect progenitor cell proliferation or SCN specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Summary: This study reveals the role of a clock-output molecule in reducing arousal circuit excitability during the active phase, suggesting a multifaceted role for the circadian clock in regulating arousal.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hester C. van Diepen, Robin A. Schoonderwoerd, Ashna Ramkisoensing, Jan A. M. Janse, Samer Hattar, Johanna H. Meijer
Summary: The study reveals the significant role of cone photoreceptors in regulating circadian rhythms, transmitting light information to the suprachiasmatic nuclei, and affecting their electrical activity levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Claudia Coomans, Dirk-Jan Saaltink, Tom Deboer, Mayke Tersteeg, Suzanne Lanooij, Anne Fleur Schneider, Aat Mulder, Jan van Minnen, Carolina Jost, Abraham J. Koster, Erno Vreugdenhil
Summary: The newly identified plasticity protein DCL is specifically expressed in the shell of the mouse suprachiasmatic nucleus and is involved in neuroplastic events that require rearrangements of the microtubule cytoskeleton for dynamic cell movement. DCL-positive astrocytes envelop AVP-expressing cells in the SCN, suggesting a role in astrocytic plasticity in regulating circadian rhythms and potentially influencing AVP biosynthesis.
Article
Neurosciences
Futaba Matsui, Sho T. T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou, Hiroaki Norimoto
Summary: Microglia, the macrophages in the brain, are not involved in the generation and light entrainment of circadian rhythms of behavior, as their depletion does not alter behavioral circadian rhythms. This suggests that the circadian rhythms of locomotor activity is unlikely to be produced by microglia.
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Frederik Elberling, Stefan Spulber, Raj Bose, Hoi Yee Keung, Virpi Ahola, Zongli Zheng, Sandra Ceccatelli
Summary: The present study aimed to investigate the long-term effects of prenatal exposure to the synthetic glucocorticoid analog dexamethasone (Dex) in adult female offspring. The study found that Dex-exposed females were more active and re-entrained slower than controls, while Dex-exposed males were less active and re-entrained faster. Following a phase shift, control females displayed transient reorganization of behavior in light, while Dex-exposed females showed limited variations in both light and dark, suggesting weaker photic entrainment. RNA sequencing in the suprachiasmatic nucleus (SCN) identified downregulated dopamine signaling and upregulated glutamate and GABA signaling in Dex-exposed females, consistent with ADHD models.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Raymond E. A. Sanchez, Franck Kalume, Horacio O. de la Iglesia
Summary: Nearly all mammals have robust daily rhythms called circadian rhythms, which are controlled by a master clock in the hypothalamus and affect various biological processes. This review summarizes the current understanding of circadian regulation of sleep, including neural circuitry, molecular mechanisms, and developmental regulation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Victoria M. Smith, Ryan T. Jeffers, Michael C. Antle
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Priyoneel Basu, Naomi Ie, Adrienne L. Wensel, Joelle D. Baskerville, Victoria M. Smith, Michael C. Antle
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Psychology, Biological
Victoria M. Smith, Ryan T. Jeffers, Brendan B. McAllister, Priyoneel Basu, Richard H. Dyck, Michael C. Antle
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Neurosciences
Victoria M. Smith, Ryan T. Jeffers, Claire Wu, Jhenkruthi Vijaya Shankara, Michael C. Antle
EXPERIMENTAL BRAIN RESEARCH
(2015)
Correction
Neurosciences
Victoria M. Smith, Stephanie Iannattone, Sanjay Achal, Ryan T. Jeffers, Michael C. Antle
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
T. Dattolo, C. P. Coomans, H. C. Van Diepen, D. F. Patton, S. Power, M. C. Antle, J. H. Meijer, R. E. Mistlberger
Article
Neurosciences
Ryan K. Chan, Roxanne Sterniczuk, Yaruuna Enkhbold, Ryan T. Jeffers, Priyoneel Basu, Bryan Duong, Sue-Len Chow, Victoria M. Smith, Michael C. Antle
Article
Neurosciences
Priyoneel Basu, Adrienne L. Wensel, Reid McKibbon, Nicole Lefebvre, Michael C. Antle
NEUROSCIENCE LETTERS
(2016)
Article
Multidisciplinary Sciences
Glenn R. Yamakawa, Priyoneel Basu, Filomeno Cortese, Johanna MacDonnell, Danica Whalley, Victoria M. Smith, Michael C. Antle
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Neurosciences
Veronika Kiryanova, Victoria M. Smith, Richard H. Dyck, Michael C. Antle
PSYCHOPHARMACOLOGY
(2017)
Article
Biology
Jordan S. Farrell, Ismael Gaxiola-Valdez, Marshal D. Wolff, Laurence S. David, Haruna I. Dika, Bryce L. Geeraert, X. Rachel Wang, Shaily Singh, Simon C. Spanswick, Jeff F. Dunn, Michael C. Antle, Paolo Federico, G. Campbell Teskey
Article
Neurosciences
Jhenkruthi Vijaya Shankara, Angelique Orr, Richelle Mychasiuk, Michael C. Antle
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Nicole E. Burma, Robert P. Bonin, Heather Leduc-Pessah, Corey Baimel, Zoe F. Cairncross, Michael Mousseau, Jhenkruthi Vijaya Shankara, Patrick L. Stemkowski, Dinara Baimoukhametova, Jaideep S. Bains, Michael C. Antle, Gerald W. Zamponi, Catherine M. Cahill, Stephanie L. Borgland, Yves De Koninck, Tuan Trang
Article
Neurosciences
Veronika Kiryanova, Victoria M. Smith, Michael C. Antle, Richard H. DycK
Article
Oncology
Sheila N. Garland, Linda E. Carlson, Alisa J. Stephens, Michael C. Antle, Charles Samuels, Tavis S. Campbell
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.