Article
Neurosciences
Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Summary: Dendritic arborization is crucial for neuronal connectivity and function, and abnormal morphology is linked to neurological disorders. This study investigates the impact of four proteins involved in cytoskeletal remodeling on dendrite morphology, revealing their distinct roles. The expression of p120-catenin and delta-catenin correlates with increased dendritic length and branching, ARVCF-catenin has no observable effect, and p0071-catenin is associated with increased dendritic branching. These findings highlight the shared and unique roles of these proteins in dendrite morphogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Agronomy
Lingxiao He, Mei Xu, Wenyan Wang, Chunyan Liu, Liang Yu, Weiguo Liu, Wenyu Yang
Summary: This study investigated the adverse effect of shading on soybean branching development and identified the interaction between strigolactones and auxins as a potential cause for this effect.
Article
Immunology
Diana Schnoegl, Mathias Hochgerner, Dagmar Gotthardt, Leigh M. Marsh
Summary: NK cell deficiency caused by aberrant expression of the transcription factor Fra-2 is associated with pulmonary fibrosis and inflammation in systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alex J. McCann, Jieqiong Lou, Mehdi Moustaqil, Matthew S. Graus, Ailisa Blum, Frank Fontaine, Hui Liu, Winnie Luu, Paulina Rudolffi-Soto, Peter Koopman, Emma Sierecki, Yann Gambin, Frederic A. Meunier, Zhe Liu, Elizabeth Hinde, Mathias Francois
Summary: The study reveals that the mutant SOX18(RaOp) disrupts the system through molecular interferences, impairing the functions of wild-type SOX18 protein, and amplifying the dominant-negative effect by poisoning the interactome of its wild-type counterpart.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biology
Fugui Niu, Peng Han, Jian Zhang, Yuanchu She, Lixin Yang, Jun Yu, Mengru Zhuang, Kezhen Tang, Yuwei Shi, Baisheng Yang, Chunqiao Liu, Bo Peng, Sheng-J Ji, Carol A. Mason
Summary: In this study, the researchers found that the m(6)A reader YTHDF2 is highly expressed in mouse RGCs, and its knockout leads to increased dendrite branching and improved visual acuity. Furthermore, Ythdf2 knockout in the retina protects RGCs from dendrite degeneration caused by acute glaucoma. The study also identified the m(6)A-modified YTHDF2 target transcripts that mediate these effects, suggesting potential new treatment approaches for glaucoma.
Article
Immunology
Zhanfeng Liang, Qian Zhang, Zhaoqi Zhang, Lina Sun, Xue Dong, Tianxiu Li, Liang Tan, Xubiao Xie, Liguang Sun, Yong Zhao
Summary: Tsc1 regulates the homeostasis of thymic medullary epithelial cells by inhibiting lysosomal-mediated apoptosis pathway. Deficiency of Tsc1 leads to developmental defects in mTECs and disrupts T cell homeostasis. The dysfunction of mTECs in Tsc1-deficient mice is associated with increased lysosomal biogenesis, cell metabolism, and apoptosis pathways, leading to reactive oxygen species overproduction and lysosome malfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gisela Altes, Marta Vaquero, Sara Cuesta, Carlos Anerillas, Anna Macia, Carme Espinet, Joan Ribera, Saverio Bellusci, Ophir D. Klein, Andree Yeramian, Xavi Dolcet, Joaquim Egea, Mario Encinas
Summary: The Wolffian ducts (WD) play a crucial role in the development of the mammalian genitourinary tract. This study reveals that mutation of tyrosine 53 of Spry1 generates a dominant negative allele that leads to developmental defects in the caudal portions of the WD. These defects include ectopically branched seminal vesicles in males and persistent WD in females. The study also shows that these defects can be rescued by lowering Fgf10 levels.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Developmental Biology
Ksenia Serdyukova, Alison R. Swearingen, Mariel Coradin, Mika Nevo, Huong Tran, Emir Bajric, Justin Brumbaugh
Summary: Histone modifications play an important role in regulating gene expression, but establishing a causal relationship between histone marks and biological processes is challenging. Mutagenesis studies using K-to-M mutants can be used to manipulate histone modifications and understand the role of histone methylation during development and homeostasis.
Article
Cell Biology
Satoshi Fujimoto, Marcus N. Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai
Summary: In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition plays a role in synapse elimination, but how different synapses compete within a post-synaptic cell has been unknown. This study investigates how a mitral cell in the mouse olfactory bulb prunes all but one primary dendrite during the developmental remodeling process. The findings reveal the importance of spontaneous activity in the olfactory bulb and demonstrate a general principle whereby activity-dependent lateral inhibition across synapses establishes a discrete receptive field of a neuron.
DEVELOPMENTAL CELL
(2023)
Review
Immunology
Jia Wang, Kun Xiong, Qu Pan, Weifeng He, Yanguang Cong
Summary: Bacteria require scarce nutrients like iron and nickel for growth, which are competitively absorbed from the environment by Gram-negative bacteria through the secretion of chelators. TonB-dependent transporters play a crucial role in mediating the transport of these nutrients into bacterial cells, making them excellent candidates for vaccine development. Researchers have recently explored the potential application of a large number of TBDTs in immune control of corresponding pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Tiphaine Arlabosse, Marie Materna, Orbicia Riccio, Caroline Schnider, Federica Angelini, Matthieu Perreau, Isabelle Rochat, Andrea Superti-Furga, Belinda Campos-Xavier, Sebastien Heritier, Anais Pereira, Caroline Deswarte, Romain Levy, Marco Distefano, Jacinta Bustamante, Marie Roelens, Raphael Borie, Mathilde Le Brun, Bruno Crestani, Jean-Laurent Casanova, Anne Puel, Michael Hofer, Claire Fieschi, Katerina Theodoropoulou, Vivien Beziat, Fabio Candotti
Summary: Patients with autosomal dominant hyper-IgE syndrome suffer from various symptoms, such as recurrent infections, severe allergies, and skeletal abnormalities. The condition is usually caused by dominant-negative STAT3 variants. Recently, new dominant-negative IL6ST variants have been discovered in three unrelated families, with different biochemical and clinical impacts compared to previously reported variants.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Chang Xie, Shaun R. Abrams, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Jeremy F. Reiter
Summary: Removing centrioles in the mouse endoderm did not affect intestinal growth but blocked lung branching. Acentriolar lung cells apoptosed due to p53 activation, while ERK activity in the endoderm influenced the developmental consequences of centriolar defects and p53 activation.
DEVELOPMENTAL CELL
(2021)
Article
Chemistry, Physical
Qi Li, Yi -lei Li, Bo Li, Ying-juan Hao, Xiao-jing Wang, Rui-hong Liu, Yuan Ling, Xinying Liu, Fa-tang Li
Summary: This study investigated the role of the main {314} facet of Bi5O7I, finding that increasing the {008} facet proportion did not effectively improve its activity, while controllable oxygen vacancy concentration could be achieved by constructing a reduction atmosphere. The results showed that the synergistic effect of facet ratio and oxygen vacancies led to an enhancement in charge carrier performance.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Chemistry, Multidisciplinary
Karnini Singh, Rajesh Gujju, Sateesh Bandaru, Sunil Misra, Katragadda Suresh Babu, Nagaprasad Puvvada
Summary: This research investigates the facet-dependent activity of Ag3PO4nanostructures (APNs) containing silver in antibacterial and biofilm degradation. The cubic APNs exhibit superior antibacterial effects compared to the rhombic dodecahedral and tetrahedral-shaped APNs due to the presence of {100} facets. This study suggests that the shape of the nanostructures plays a significant role in their enzyme-mimetic activity, providing a direction for optimizing bactericidal materials.
Article
Allergy
Laura Barrett Ryo, Didde Haslund, Anne Bruun Rovsing, Rasmus Pihl, Wariya Sanrattana, Steven de Maat, Yaseelan Palarasah, Coen Maas, Steffen Thiel, Jacob Giehm Mikkelsen
Summary: This study investigates the trans-inhibitory effects of different SERPING1 variants on the expression, secretion, functionality, and intracellular localization of C1 inhibitor (C1INH) in HeLa cells. The findings suggest that different SERPING1 variants may drive the pathogenicity of hereditary angioedema through different and sometimes overlapping molecular disease mechanisms, with some variants acting as dominant-negative factors.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Neurosciences
Fiona M. Inglis, Kim M. Lee, Kevin B. Chiu, Olivia M. Purcell, Peter J. Didier, Kasi Russell-Lodrigue, Scott C. Weaver, Chad J. Roy, Andrew G. MacLean
JOURNAL OF NEUROVIROLOGY
(2016)
Article
Developmental Biology
Ranjini Prithviraj, Kristen M. Kelly, Ramon Espinoza-Lewis, Tia Hexom, Amy B. Clark, Fiona M. Inglis
DEVELOPMENTAL NEUROBIOLOGY
(2008)
Article
Developmental Biology
Christina C. Thomas, Crescent L. Combe, Kenneth A. Dyar, Fiona M. Inglis
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2008)
Article
Cell Biology
Nicole A. Renner, Hope A. Sansing, Fiona M. Inglis, Smriti Mehra, Deepak Kaushal, Andrew A. Lackner, Andrew G. MacLean
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
Article
Immunology
Geeta Ramesh, Lenay Santana-Gould, Fiona M. Inglis, John D. England, Mario T. Philipp
JOURNAL OF NEUROINFLAMMATION
(2013)
Article
Neurosciences
Hongbo He, Amanda H. Mahnke, Sukhjeevan Doyle, Ni Fan, Chih-Chieh Wang, Benjamin J. Hall, Ya-Ping Tang, Fiona M. Inglis, Chu Chen, Jeffrey D. Erickson
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Nicole A. Renner, Hope A. Sansing, Lisa A. Morici, Fiona M. Inglis, Andrew A. Lackner, Andrew G. MacLean
JOURNAL OF NEUROVIROLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Qinbo Zhou, Chastain Anderson, Hongmei Zhang, Xinyu Li, Fiona Inglis, Ashwath Jayagopal, Shusheng Wang
Article
Neurosciences
W. Chen, R. Prithviraj, A. H. Mahnke, K. E. Mcgloin, J. W. Tan, A. K. Gooch, F. M. Inglis
Article
Neurosciences
June G. Allison, Partha M. Das, Jingjing Ma, Fiona M. Inglis, Frank E. Jones
NEUROSCIENCE RESEARCH
(2011)
Article
Multidisciplinary Sciences
Kim M. Lee, Kevin B. Chiu, Hope A. Sansing, Fiona M. Inglis, Kate C. Baker, Andrew G. MacLean
Article
Neurosciences
Thomas N. Greenwell, Sheryl Martin-Schild, Fiona M. Inglis, James E. Zadina
JOURNAL OF COMPARATIVE NEUROLOGY
(2007)
Article
Neurosciences
FM Inglis, R Crockett, S Korada, WC Abraham, M Hollmann, RG Kalb
JOURNAL OF NEUROSCIENCE
(2002)
Article
Neurosciences
Douglas L. Sheridan, Catherine H. Berlot, Antoine Robert, Fiona M. Inglis, Klara B. Jakobsdottir, James R. Howe, Thomas E. Hughes
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.