期刊
NEUROREPORT
卷 25, 期 17, 页码 1344-1349出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000000267
关键词
intrinsic connectivity network; low-frequency fluctuation; MRI; resting state; schizophrenia
资金
- National Basic Research Program of China [2011CB707802]
- National Science Foundation of China [61375111]
Increasingly more neuroimaging studies have shown that the complex symptoms of schizophrenia are linked to disrupted neural circuits and dysconnectivity of intrinsic connectivity networks. Previous studies have assumed temporal stationarity of resting-state functional connectivity, whereas temporal dynamics have rarely been explored. Here, we utilized resting-state functional MRI with a sliding window approach to measure the amplitude of low-frequency fluctuations (ALFFs) in functional connectivity in 24 patients with schizophrenia and 25 healthy controls. We found that there were significant differences in the ALFFs of specific connections, the majority of which were located between the intrinsic connectivity networks. Importantly, the experimental results of a multivariate pattern analysis of these ALFF measures showed that 81.3% (P<0.0009) of the participants were correctly classified as either schizophrenic patients or healthy controls by leave-one-out cross-validation. Our results show significant abnormality in the dynamics of internetwork functional connectivity in schizophrenia, which contributes toward the characterization and differentiation of schizophrenic patients, and may be used as a potential biomarker. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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