期刊
NEUROREPORT
卷 24, 期 3, 页码 114-119出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32835cf179
关键词
Cdyl; induced pluripotent stem cells; neuronal differentiation
资金
- National Basic Research Program of China [2012CBA01302, 2010CB945401, 2009CB522104]
- National Natural Science Foundation of China [81271265, 30971675, 30928015, U0932006]
- National High Technology Research and Development Program of China [2011AA020108]
- Key Scientific and Technological Projects of Guangdong Province [2007A032100003]
Chromodomain on Y-like (CDYL) is a chromodomain protein that has sequence homology to members of the enoyl CoA hydratase family. Although the chromodomain of CDYL has been implicated in chromatin remodeling during mammalian spermatogenesis, the function of the Cdyl gene remains unclear. Recently, induced pluripotent stem cells (iPS cells) have been derived from somatic cells by the forced expression of several transcription factors. iPS cells resemble embryonic stem cells in many respects. Therefore, iPS cells represent a powerful tool for the study of gene function. In this study, we have investigated whether iPS cells derived from Cdyl-/- and Cdyl+/+ fibroblasts have different characteristics. Our results showed that both Cdyl-/- and Cdyl+/+ fibroblasts could be induced to become iPS cells, but the spontaneous neuronal differentiation capacity of Cdyl-/- iPS cells was much greater than that of the Cdyl+/+ iPS cells. These results provide some insight into the molecular function of the Cdyl gene, showing that it inhibited the neuronal differentiation of iPS cells. NeuroReport 24:114-119 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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