期刊
NEUROREPORT
卷 22, 期 16, 页码 789-794出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32834acb54
关键词
mice; neural stem cells; neurogenesis; pyramidal neurons; stroke
资金
- Ministry of Education, Culture, Sports, Science, and Technology [21500359]
- Hyogo Science and Technology Association
- Grants-in-Aid for Scientific Research [21500359] Funding Source: KAKEN
Adult brain-derived neural stem cells have acquired a lot of interest as an endurable neuronal cell source that can be used for central nervous system repair in a wide range of neurological disorders such as ischemic stroke. Recently, we identified injury-induced neural stem/progenitor cells in the poststroke murine cerebral cortex. In this study, we show that, after differentiation in vitro, injury-induced neural stem/progenitor cells express pyramidal cell markers Emx1 and CaMKII alpha, as well as mature neuron markers MAP2 and Tuj1. 5-bromo-2-deoxyuridinine-positive neurons in the peristroke cortex also express such pyramidal markers. The presence of newly regenerated pyramidal neurons in the poststroke brain might provide a noninvasive therapeutic strategy for stroke treatment with functional recovery. NeuroReport 22:789-794 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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