期刊
NEUROREPORT
卷 22, 期 13, 页码 629-632出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283491665
关键词
cadherin; electrophysiology; hippocampal culture neuron; miniature excitatory postsynaptic current
资金
- Japan Society of Promotion of Science [21700365]
- National Institute of Physiological Sciences
- Grants-in-Aid for Scientific Research [21700365] Funding Source: KAKEN
Cadherins, cell adhesion molecules widely expressed in the nervous system, are thought to be involved in synapse formation and function. To explore the role of cadherins in neuronal activity, we performed electrophysiological and morphological analyses of rat hippocampal cultured neurons overexpressing type-II cadherins, such as cadherin-6B and cadherin-7. We found that cadherin-6B increased but cadherin-7 decreased the number of protrusions of dendritic spines, and affected the frequency of miniature excitatory postsynaptic currents. Our results suggest that type-II cadherins may modulate neural activity by regulating neuronal morphology. NeuroReport 22:629-632 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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