期刊
NEUROREPORT
卷 21, 期 8, 页码 585-589出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833a7dc4
关键词
BrdU; cell proliferation; doublecortin; infrasound; subgranular zone
资金
- National Natural Science Foundation of China [30570443]
Adult rats were used to identify the effects of infrasound on neurogenesis in the hippocampal dentate gyrus. After 7 consecutive days' exposure to infrasound of 16 Hz at 130 dB, immunostaining of 5-bromo-2'-deoxyuridine (BrdU) and doublecortin (DCX) was preformed. Compared with those in normal groups, the numbers of BrdU(+) and DCX+/BrdU(+) cells in the subgranular zone in infrasound groups were significantly decreased at 3, 6, 10 and 14 days and returned to normal at 18 days. The percentage of BrdU(+) cells that were co-labeled with DCX showed no significant differences between the infrasound and normal groups. These data suggest that infrasound inhibits the cell proliferation in adult rat dentate gyrus but has no effects on early migration and differentiation of these newborn cells. NeuroReport 21:585-589 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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