期刊
NEUROREPORT
卷 21, 期 17, 页码 1111-1115出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283407204
关键词
aggression; Alzheimer's disease; dementia; hippocampus; neurofibrillary tangles; neuropsychiatric behaviours
资金
- National Medical Research Council [NMRC/CG/NUHS/2010]
Neuropsychiatric behaviours occur frequently in Alzheimer's disease and other dementias and are thought to arise from the neurodegenerative process. However, it is unclear whether neurodegenerative changes in the hippocampus are associated with neuropsychiatric behaviours such as aggression. In this study, semiquantitative measurements of cell loss, atrophy, neuritic plaque and neurofibrillary tangle load in the postmortem hippocampus were taken for dementia patients, prospectively assessed for neuropsychiatric behaviours. It was found that increased tangle load, but not other hippocampal neuropathological variables, was associated with increased severity of aggressive behaviours and presence of chronic aggression. This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients. NeuroReport 21:1111-1115 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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