期刊
NEUROREPORT
卷 21, 期 9, 页码 623-628出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328339b5f9
关键词
learning and memory; Morris water maze; neuropeptide S; phosphorylated cAMP-response element binding protein; rapid eye movement sleep deprivation
资金
- Shanghai Committee of Science and Technology [09DZ1950 400]
- Shanghai Science and Technology Development Foundation [08411950700]
- National Youth Natural Science Foundation of China [30900473]
Rapid eye movement (REM) sleep deprivation causes learning and memory deficits. Neuropeptide S, a newly discovered neuropeptide, has been shown to regulate arousal, anxiety, and may enhance long-term memory formation and spatial memory. However, it is unknown whether neuropeptide S could improve the REM sleep deprivation-induced memory impairment. Here, we report that 72-h REM sleep deprivation in rats resulted in spatial memory impairment and reduced phosphorylation level of cAMP-response element binding protein in the hippocampus, both of which were reversed by central administration of neuropeptide S. The results suggest that neuropeptide S mitigates spatial memory impairment in rats induced by 72-h REM sleep deprivation, possibly through activating cAMP-response element binding protein phosphorylation in the hippocampus. NeuroReport 21: 623-628 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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