期刊
NEUROREPORT
卷 20, 期 9, 页码 881-885出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832c5eb2
关键词
dorsal hippocampus; high throughput; pattern separation; spatial learning
资金
- Alzheimer's Research Trust
- University of Cambridge
- MRC/Wellcome Trust Behavioural
- Clinical Neurosciences Institute
- Medical Research Council [G0001354, G0001354B] Funding Source: researchfish
Researchers are becoming increasingly interested in the role of the hippocampus in pattern separation, a process which keeps items distinct in memory. In this study, we develop and test a new automated touchscreen-based method for studying pattern separation in rodents. Rats were trained to discriminate locations on a computer screen that varied in their similarity, that is, their distance apart on the screen. Animals with lesions of the dorsal hippocampus were impaired when the locations discriminated were close together but not when they were far apart, indicating impaired pattern separation. This test provides an automated test of pattern separation, which adds to an expanding battery of cognitive tests that can be carried out using the touchscreen testing method. NeuroReport 20:881-885 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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