Review
Psychiatry
Michael K. Yeung, Jingxia Lin
Summary: The majority of psychiatric patients showed significantly reduced changes in oxyhemoglobin concentrations and significantly fewer produced words during the VFT, indicating that changes in HbO are more sensitive for most psychiatric disorders. Meta-analyses revealed hypoactivation in frontotemporal regions for major depression and schizophrenia, with disorder-specific topographical distribution. Findings suggest that the fNIRS-VFT paradigm holds promise for understanding and differentiating psychiatric disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Bei Luo, Wenwen Dong, Lei Chang, Chang Qiu, Yue Lu, Dongming Liu, Chen Xue, Li Zhang, Weiguo Liu, Wenbin Zhang, Jun Yan
Summary: This study investigated the changes in interhemispheric functional connectivity after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). It was found that PD patients exhibited a coordination disorder in the prefrontal cortex, cerebellum, and other regions after STN-DBS. Furthermore, a positive correlation between reduced functional connectivity and decreased verbal fluency (VF) scores was observed.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Gabriel Solana-Lavalle, Roberto Rosas-Romero
Summary: This study proposes a new method for classifying 3-D MRI scans as an assisting tool for Parkinson's disease diagnosis, using separate experiments for men and women due to gender differences in disease prevalence. High detection performance was achieved, with men showing 99.01% accuracy and women showing 96.97% accuracy in classification experiments, highlighting the effectiveness of the proposed approach.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
Jitian Guan, Qiuyu Li, Zhuozhi Dai, Lingfeng Lai, Shuyi Sun, Yiqun Geng, Zhiwei Shen, Lan Luo, Yanlong Jia, Lin Yang, Yanyan Tang, Gen Yan, Renhua Wu
Summary: Vascular mild cognitive impairment (VMCI) is an early and reversible stage of dementia. This study used voxel-based morphometry to analyze the morphological characteristics of two common types of VMCI, periventricular white matter hyperintensities (PWMH) and strategic single infarctions (SSI), and found that PWMH patients had more similar gray matter atrophy characteristics to Alzheimer's disease, suggesting a higher risk of progression to dementia compared to SSI patients.
Article
Clinical Neurology
Shefali Chaudhary, S. Senthil Kumaran, Vinay Goyal, M. Kalaivani, Gauri Shanker Kaloiya, Rajesh Sagar, Nalin Mehta, Achal Kumar Srivastava, N. R. Jagannathan
Summary: Through multi-voxel proton magnetic resonance spectroscopic imaging, it was found that metabolic alterations in the frontal lobe of cognitively impaired PD patients could be potential biomarkers for PD cognitive impairment, involving neuronal function loss, altered energy metabolism, and cholinergic neural transmission. These findings may serve as promising indicators for early diagnosis and monitoring of PD cognitive impairment.
NEUROLOGICAL SCIENCES
(2021)
Article
Neuroimaging
Alejandro N. Santos, Ferath Kherif, Lester Melie-Garcia, Antonie Lutti, Alessio Chiappini, Laurel Rauschenbach, Thiemo F. Dinger, Christoph Riess, Amir El Rahal, Marvin Darkwah Oppong, Ulrich Sure, Philipp Dammann, Bogdan Draganski
Summary: There is ongoing debate about the differential clinical outcome and associated adverse effects of deep brain stimulation (DBS) in Parkinson's disease (PD) targeting the subthalamic nucleus (STN) or the globus pallidus pars interna (GPi). In this study, the authors investigate the structural covariance brain patterns associated with STN and GPi in PD patients and healthy controls using magnetic resonance imaging (MRI).
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Giulia Donzuso, Roberto Monastero, Calogero E. Cicero, Antonina Luca, Giovanni Mostile, Loretta Giuliano, Roberta Baschi, Maria Caccamo, Cesare Gagliardo, Stefano Palmucci, Mario Zappia, Alessandra Nicoletti
Summary: The study revealed significant gray matter reduction in multiple brain regions in PD-MCI patients, with early PD-MCI patients mainly showing GM density reduction in the frontal gyrus and cerebellum. There were associations between neuropsychological performances and brain gray matter volume in early PD-MCI patients.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qihao Zhang, Chaofan Sui, Junghun Cho, Linfeng Yang, Tao Chen, Bin Guo, Kelly McCabe Gillen, Jing Li, Lingfei Guo, Yi Wang
Summary: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism in preeclampsia. By studying 49 women with preeclampsia, 22 pregnant healthy controls, and 40 non-pregnant healthy controls, it was found that the preeclampsia group had significantly higher brain oxygen extraction fraction (OEF) values compared to the control groups.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Giulia Donzuso, Giorgia Sciacca, Cristina Rascuna, Calogero E. Cicero, Giovanni Mostile, Alessandra Nicoletti, Mario Zappia
Summary: The long-duration response (LDR) to L-dopa is a sustained benefit in treating Parkinson's disease (PD) patients, with structural changes in cortical areas related to motor control potentially predisposing individuals to develop LDR. This exploratory study suggests that neuroanatomical substrate may play a role in the development of LDR to L-dopa in PD patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Francina Hartmann, Julia Reinhardt, Christoph Stippich, Sabine Krumm
Summary: Voxel-based morphometry (VBM) is a method used to assess grey matter volumes in the brain, and the quality of MRI and data preprocessing steps can affect the results. This study found a lack of standardized protocols and that manual correction of voxel misclassification had minimal impact on Alzheimer's disease research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Yingying Yang, Quan Zhang, Jialiang Ren, Qingfeng Zhu, Lixin Wang, Yongzhi Zhang, Zuojun Geng
Summary: This study aimed to investigate the synergistic effects of hypertension and aging on brain morphology, especially in terms of gray matter atrophy. The results revealed interactive effects on tissue volumes, with the most pronounced gray matter atrophy observed in elderly SHRs. Specific brain regions, including the septal region, bilateral caudate putamen, hippocampus, and others, were identified as vulnerable to combined effects of hypertension and aging. Additionally, an inverted-U trajectory of volume change in SHRs was observed, with an increase in volume at the early phase followed by a decline in the late phase.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Environmental Sciences
Travis J. Beckwith, Kim N. Dietrich, John P. Wright, Mekibib Altaye, Kim M. Cecil
Summary: Childhood lead exposure is linked to decreased brain volumes in regions responsible for cognition and emotional regulation, which in turn are associated with increased rates of criminal arrests in adulthood.
ENVIRONMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Jun Shu, Qiang Qiang, Yuning Yan, Yang Wen, Yiqing Ren, Wenshi Wei, Li Zhang
Summary: This cross-sectional study evaluated gray matter changes in cognitively normal elderly adults with mild behavioral impairment (MBI), finding decreased volume in certain brain regions in the MBI group. MBI patients had shorter education years and higher MBI-C, GDS, and SAS scores. The results suggest that MBI may be an early indicator of cognitive decline and dementia.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Heng Zhang, Ai-di Shan, Cai-ting Gan, Li Zhang, Li-na Wang, Hui-min Sun, Yong-sheng Yuan, Ke-zhong Zhang
Summary: The study found significantly decreased functional connections in the nucleus accumbens and putamen in apathetic PD patients compared to both non-apathetic PD patients and healthy controls. These findings suggest that asymmetric functional connectivity in the mesocorticolimbic and nigrostriatal systems may contribute to the pathophysiological mechanisms of apathy in PD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Kilian Abellaneda-Perez, Lidia Vaque-Alcazar, Cristina Sole-Padulles, David Bartres-Faz
Summary: This article describes how the combination of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) can provide new insights into the neurophysiological mechanisms underlying inter-individual differences in cognitive status among older adults. It explores the evidence of how this combined procedure can modify brain networks and improve cognitive function and mental health status in older adults.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Clinical Neurology
Anna Campabadal, Alexandra Abos, Barbara Segura, Gemma Monte-Rubio, Alexandra Perez-Soriano, Darly Milena Giraldo, Esteban Munoz, Yaroslau Compta, Carme Junque, Maria Jose Marti
Summary: Multiple system atrophy (MSA) can be classified into two subtypes based on symptoms, and this study found differential gray matter atrophy distribution between MSA-C and MSA-P using MRI. Cerebellar atrophy is a significant differentiator between the two subtypes.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Javier Oltra, Barbara Segura, Carme Uribe, Gemma C. Monte-Rubio, Anna Campabadal, Anna Inguanzo, Jessica Pardo, Maria J. Marti, Yaroslau Compta, Francesc Valldeoriola, Alex Iranzo, Carme Junque
Summary: This study found that male patients with Parkinson's disease and probable RBD show more severe cognitive impairment and brain atrophy compared to female patients with the same conditions, indicating a significant impact of sex differences on PD patients with probable RBD.
JOURNAL OF NEUROLOGY
(2022)
Correction
Multidisciplinary Sciences
Kilian Abellaneda-Perez, Pablo Martin-Trias, Catherine Casse-Perrot, Lidia Vaque-Alcazar, Laura Lanteaume, Elisabeth Solana, Claudio Babiloni, Roberta Lizio, Carme Junque, Nuria Bargallo, Paolo Maria Rossini, Joelle Micallef, Romain Truillet, Estelle Charles, Elisabeth Jouve, Regis Bordet, Joan Santamaria, Simone Rossi, Alvaro Pascual-Leone, Olivier Blin, Jill Richardson, Jorge Jovicich, David Bartres-Faz
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kilian Abellaneda-Perez, Pablo Martin-Trias, Catherine Casse-Perrot, Lidia Vaque-Alcazar, Laura Lanteaume, Elisabeth Solana, Claudio Babiloni, Roberta Lizio, Carme Junque, Nuria Bargallo, Paolo Maria Rossini, Joelle Micallef, Romain Truillet, Estelle Charles, Elisabeth Jouve, Regis Bordet, Joan Santamaria, Simone Rossi, Alvaro Pascual-Leone, Olivier Blin, Jill Richardson, Jorge Jovicich, David Bartres-Faz
Summary: The BDNF Val66Met gene polymorphism influences individual responses to TMS in memory tasks, particularly in Val/Val genotype carriers, who show reduced memory performance with rTMS over the left frontal cortex. This genetic variation is also associated with increased brain activity during memory recognition, specifically in frontal regions, which correlates positively with cognitive performance.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Public, Environmental & Occupational Health
Rebecca B. Carver, Nanna Alida Grit Fredheim, Athanasia Monika Mowinckel, Klaus P. Ebmeier, Barbara Bodorkos Friedman, Tor Atle Rosness, Christian A. Drevon, Sana Suri, William F. C. Baare, Eniko Zsoldos, Cristina Sole-Padulles, David Bartres-Faz, Paolo Ghisletta, Laura Nawijn, Sandra Duezel, Kathrine Skak Madsen, Anders M. Fjell, Ulman Lindenberger, Kristine B. Walhovd, Isabelle Budin-Ljosne
Summary: This study investigated people's willingness and reasons to take a brain health test. The results showed a high public interest in brain health testing, with the main reason being the ability to respond if at risk of brain disease. Men, respondents with lower education levels, and those with poor self-reported cognitive health had higher interest in brain health testing.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Neurosciences
Maria Cabello-Toscano, Lidia Vaque-Alcazar, Gabriele Cattaneo, Javier Solana-Sanchez, Ivet Bayes-Marin, Kilian Abellaneda-Perez, Didac Macia-Bros, Lidia Mulet-Pons, Cristina Portellano-Ortiz, Miquel Angel Fullana, Laura Oleaga, Sofia Gonzalez, Nuria Bargallo, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study investigates the resilience to the mental health impact of the COVID-19 pandemic and identifies the demographic, psychological, and neurobiological factors associated with interindividual differences. The findings suggest that age, sex, coping strategies, and brain network status are all related to mental health. Therefore, preventive strategies should consider these factors to promote mental health during similar adverse events.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychology, Multidisciplinary
Maria Redondo-Camos, Gabriele Cattaneo, Vanessa Alviarez-Schulze, Selma Delgado-Gallen, Goretti Espana-Irla, Javier Solana-Sanchez, Ruben Perellon-Alfonso, Sergiu Albu, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study found an association between excitability of the primary motor cortex and cognitive functioning in healthy middle-aged adults, particularly with regards to working memory performance. Furthermore, the role of biological sex was identified as critical in this association.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Ruben Perellon-Alfonso, Maria Redondo-Camos, Kilian Abellaneda-Perez, Gabriele Cattaneo, Selma Delgado-Gallen, Goretti Espana-Iria, Javier Solana Sanchez, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: Psychosocial hardships associated with the COVID-19 pandemic have negative effects on individuals' mental health. By analyzing the EEG response and transcranial magnetic stimulation, we found that this response can predict individuals' mental health status during the pandemic.
Article
Clinical Neurology
Anna Campabadal, Javier Oltra, Carme Junque, Nuria Guillen, Maria Angeles Boti, Roser Sala-Llonch, Gemma C. Monte-Rubio, Gema Lledo, Nuria Bargallo, Lorena Rami, Raquel Sanchez-Valle, Barbara Segura
Summary: This study investigates structural brain changes in patients with persistent olfactory dysfunctions after COVID-19. It found differences in gray matter volume and diffusion in the olfactory system among COVID-19 patients, which can explain the prolonged olfactory deficits in these patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Isabelle Budin-Ljosne, Barbara B. Friedman, William F. C. Baare, David Bartres-Faz, Rebecca B. Carver, Christian A. Drevon, Klaus P. Ebmeier, Anders M. Fjell, Paolo Ghisletta, Richard N. Henson, Rogier Kievit, Kathrine S. Madsen, Laura Nawijn, Sana Suri, Cristina Sole-Padulles, Kristine B. Walhovd, Eniko Zsoldos
Summary: The involvement of stakeholders in the "Lifebrain" project was seen as meaningful and relevant, benefiting both researchers and stakeholders. However, there were barriers such as lack of time, difficulties in identifying relevant stakeholders, and challenges in communicating scientific issues. Stakeholder engagement in basic brain research requires dedicated resources, clear communication, and defined roles and responsibilities.
HEALTH EXPECTATIONS
(2023)
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychiatry
I. Bayes-Marin, M. Cabello-Toscano, G. Cattaneo, J. Solana-Sanchez, D. Fernandez, C. Portellano-Ortiz, J. M. Tormos, A. Pascual-Leone, D. Bartres-Faz
Summary: The study aimed to identify trajectories of mental health during a two-year follow-up of the COVID-19 pandemic and investigate the associations between these trajectories and various factors. They found that most participants belonged to the "resilient" trajectory, while a smaller proportion belonged to the "chronic-worsening" trajectory. Protective factors and risk factors played different roles in different mental health outcomes.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Article
Neuroimaging
Julia Binnewies, Laura Nawijn, Andreas M. Brandmaier, William F. C. Baare, David Bartres-Faz, Christian A. Drevon, Sandra Duezel, Anders M. Fjell, Laura K. M. Han, Ethan Knights, Ulman Lindenberger, Yuri Milaneschi, Athanasia M. Mowinckel, Lars Nyberg, Anna Plachti, Kathrine Skak Madsen, Cristina Sole-Padulles, Sana Suri, Kristine B. Walhovd, Eniko Zsoldos, Klaus P. Ebmeier, Brenda W. J. H. Penninx
Summary: This study investigated the association between depressive symptoms and depression status with brain structures, and found that in clinical patient-control cohorts, both depressive symptoms and depression status were associated with lower thickness and volume of specific brain regions, while no such associations were observed in the general population.
NEUROIMAGE-CLINICAL
(2022)
