Article
Neurosciences
Ting-Chun Lin, Yi-Chieh Tsai, Yun-An Chen, Tai-Horng Young, Chung-Che Wu, Yung-Hsiao Chiang, Chia-Hsin Kao, Abel Po-Hao Huang, Yi-Hua Hsu, Kai-Yun Chen, Li-Kai Tsai
Summary: This study investigated the role of brain-derived neurotrophic factor (BDNF) in post-ICH neurogenesis using a rodent model and patients with ICH. The results showed that the BDNF concentration in cerebrospinal fluid (CSF) was positively correlated with neurogenesis-promoting capacity. This suggests that BDNF plays an important role in regulating neurogenesis after ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger
Summary: Aberrant neurogenesis in the subventricular zone and hippocampus contributes to schizophrenia pathogenesis. The commonly prescribed antipsychotics haloperidol and olanzapine affect neurogenesis. This study investigates the effects of these drugs on cell proliferation and gene expression in vitro and in an animal schizophrenia model. The results suggest that chronic treatment with haloperidol and olanzapine can inhibit gene expression, but olanzapine can reverse the inhibitory effect of another drug in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mikhail Semenov
Summary: The study focused on cell proliferation in the postnatal mouse brain, identifying four compartments with different densities of proliferating cells. It estimated the number of new cells produced in each compartment and concluded that adult neurogenesis only supports compensatory regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Nan Yao, Yulin Li, Jinrui Han, Siting Wu, Xin Liu, Qiuyu Wang, Zhiguo Li, Fu-Dong Shi
Summary: This study reveals the detrimental role of microglia in neurogenesis and neurorepair after intraventricular hemorrhage (IVH), with CC chemokine ligand 20 (CCL20) playing a likely role in promoting pro-inflammatory responses and neural injury.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Article
Biology
John C. O'Donnell, Erin M. Purvis, Kaila V. T. Helm, Dayo O. Adewole, Qunzhou Zhang, Anh D. Le, D. Kacy Cullen
Summary: The Tissue-Engineered Rostral Migratory Stream (TE-RMS) developed by O'Donnell et al. uses astrocyte-like cells derived from adult gingival stem cells to facilitate directed migration of immature neurons and redirect neuroblast migration in athymic rat brains, offering a promising new approach to neuroregenerative medicine.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pediatrics
Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Hypoxia-ischemia can lead to a decrease in cell proliferation and neurogenesis in the neurogenic niche of the neonatal piglet, which may hinder the replacement of lost neurons and overall repair.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
Summary: BDNF shows significant gender differences and left-right asymmetries in the developing rat hippocampus, potentially influencing the gender and laterality differences in the development, structure, and function of the hippocampus.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Christin Weissleder, Hayley F. North, Maina Bitar, Janice M. Fullerton, Rachel Sager, Guy Barry, Michael Piper, Glenda M. Halliday, Maree J. Webster, Cynthia Shannon Weickert
Summary: The study found that the human SEZ retains the capacity to generate neuronal progenitor cells throughout life, but this capacity is limited in schizophrenia and bipolar disorder. Increased macrophages in the SEZ of schizophrenia patients may impair neurogenesis.
MOLECULAR PSYCHIATRY
(2021)
Article
Agriculture, Dairy & Animal Science
Allison N. Pullin, Victoria S. Farrar, Jason W. Loxterkamp, Claire T. Jones, Rebecca M. Calisi, Kristina Horback, Pamela J. Lein, Maja M. Makagon
Summary: The rearing environment did not affect neural connectivity and performance on spatial cognition tasks in pullets. Hippocampal subregion affected dendritic morphology.
Article
Neurosciences
Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimura
Summary: This study aimed to explore the relationship between hippocampal subfield volumes and plasma levels of BDNF in first-episode major depression patients. The results showed that there were no differences in total hippocampal volume between the patient group and the control group. However, specific subfields in the patient group, such as the HATA and several regions on the right side, were significantly smaller compared to the control group. Furthermore, the study found different correlations between hippocampal volume and plasma BDNF concentrations in the patient and control groups. These findings suggest that certain hippocampal subfields may already be atrophic at the onset of major depression, and the sensitivity of certain regions to BDNF may differ between the two groups.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jonathan Isacco Battistini, Valentina Mastrorilli, Vittoria Nicolis di Robilant, Daniele Saraulli, Sara Marinelli, Stefano Farioli Vecchioli
Summary: Traumatic brain injury (TBI) is a common cause of death and disability worldwide, with no effective treatments available. Recent studies have suggested that adult neurogenesis may be a new approach to counteract post-traumatic neurodegeneration. It has been shown that long-term running can enhance adult neurogenesis and promote neuroregeneration and functional recovery after injury. These findings suggest that running could be a promising method to increase neural stem cells and improve endogenous neuroregenerative responses following brain trauma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Perla Leal-Galicia, Maria Elena Chavez-Hernandez, Florencia Mata, Jesus Mata-Luevanos, Luis Miguel Rodriguez-Serrano, Alejandro Tapia-de-Jesus, Mario Humberto Buenrostro-Jauregui
Summary: The generation of new neurons in the adult brain is a well-accepted phenomenon that mainly occurs in the subventricular zone and the hippocampal dentate gyrus. These new neurons are generated through an asymmetric division process and contribute to the local circuitry with their unique properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Pu-Tien Chiang, Hsin-Hsi Tsai, Ruoh-Fang Yen, Yi-Chieh Tsai, Chi-Han Wu, Ching-Hung Chiu, Li-Kai Tsai
Summary: In this study, we assessed the use of F-18-fluorothymidine (FLT) PET to detect cerebral cell proliferation and found that it is associated with stroke severity and outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ali Ebrahimi, Kazem Parivar, Nasim Hayati-e Roodbari, Akram Eidi
Summary: This study investigated the effects of quercetin on the expression of the Nrf2 gene and the proliferation and differentiation of NPSCs derived from the brain of adult rats. The results showed that quercetin increased the expression of Nrf2 and had a dose-dependent effect on the proliferation and differentiation of NPSCs. These findings suggest that quercetin may be an effective compound for treating degenerative CNS disorders.
MOLECULAR BIOLOGY REPORTS
(2023)
