期刊
NEUROREPORT
卷 20, 期 7, 页码 698-701出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32832a5c9e
关键词
cerebellum; developing brain; external granular layer; fetal alcohol syndrome; secretin; striatum
资金
- Research Institute at Nationwide Hospital Internal Grant
Alcohol exposure during brain development induces neuronal cell death in the brain. Several neuroactive peptides have been shown to protect against alcohol-induced cell death. Secretin is a peptide hormone, and the secretin receptor is expressed in the gut and the brain. To explore a potential role of secretin signal against ethanol neurotoxicity during brain development, secretin receptor-deficient mice were exposed to ethanol on postnatal day 4. We identified significant ethanol-induced apoptosis in the external granular layer of the secretin receptor-deficient cerebellum and in the striatum after ethanol treatment. During the early postnatal period, there is a proliferation of granular cell progenitors that reside in the external granular layer. The results suggest that secretin signal plays a neuroprotective role of neuronal progenitor cells against the neurotoxicity of ethanol. NeuroReport 20:698-701 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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