期刊
NEUROREPORT
卷 20, 期 4, 页码 371-377出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328324edcd
关键词
hippocampus; neurogenesis; prepulse inhibition; prepulse inhibition disruption; sensorimotor gating; subventricular zone
资金
- Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited)
Adult neurogenesis in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests. NeuroReport 20:371-377 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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