期刊
NEUROREPORT
卷 19, 期 15, 页码 1523-1527出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328310af58
关键词
basal ganglia; bipolar disorder; functional magnetic resonance imaging; limbic system; mania; mood; neuroimaging; prefrontal cortex; striatum
资金
- NIMH [R01 MH069840]
The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful face perception task in 14 adult bipolar patients to that of 13 healthy controls. Whereas control participants showed increased orbitofrontal, anterior cingulate, and striatum activity during the late (vs. early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve corticostriatal dysfunction.
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