期刊
NEUROREPORT
卷 19, 期 10, 页码 1045-1048出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283036e73
关键词
action monitoring; anterior cingulate cortex; depression; executive function; feedback-related negativity; negative bias; punishment; reinforcement learning; remission
资金
- NIMH NIH HHS [R01 MH068376-01A1, R01 MH068376-04, F31 MH074246-01A2, R01 MH068376-02, R01 MH068376-06A1, R01 MH068376-05, R01 MH068376-07, F31 MH7424601, F31 MH074246, R01 MH68376, R01 MH068376-03, R01 MH068376] Funding Source: Medline
Major depressive disorder (MDD)is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction. MDD patients exhibit enhanced electrophysiological responses to negative internal (errors) and external (feedback) cues. Whether this dysfunction extends to remitted depressed (RD) individuals with a history of MDD is currently unknown. To address this issue, we examined the feedback-related negativity in RD and control participants using a probabilistic punishment learning task. Despite equivalent behavioral performance, RD participants showed larger feedback-related negativities to negative feedback relative to controls; group differences remained after accounting for residual anxiety and depressive symptoms. The present findings suggest that abnormal responses to negative feedback extend to samples at increased risk for depressive episodes in the absence of current symptoms.
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