期刊
NEUROREPORT
卷 19, 期 18, 页码 1745-1749出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283186fd7
关键词
apoptosis; morphine; neurons; protection
资金
- National Science Foundation of China [30670658, 30370455, 30470542]
- Peking University President Research Grant
- Ministry of Education Recruiting Research Grant
- Ministry of Science and Technology of China [0066500706]
Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application and addiction, the effects of chronic morphine treatments were examined in primary cultured human neurons. Our results show that, surprisingly, morphine protects cultured human neurons against serum deprivation and staurosporine induced cytotoxicity. Morphine downregulates proapoptotic factor Bax levels in cultured human neurons. In addition, heat shock protein 70 is also involved in morphine protection. Our data suggest that chronic morphine application may be beneficial to stimulate cell survival. NeuroReport 19:1745-1749 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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