期刊
NEUROREPORT
卷 19, 期 17, 页码 1733-1738出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3283186bf8
关键词
cell survival; leukocyte tyrosine kinase; neurite outgrowth; phosphorylation; signaling pathway
资金
- New Energy and Industrial Technology Development Organization
In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we constructed a chimeric receptor, in which the extracellular domain of the receptor for colony-stimulating factor-1 was fused to the cytoplasmic domain of LTK, which allowed the selective activation of LTK by colony-stimulating factor-1. Our studies using this chimeric receptor suggest that activation of the tyrosine kinase activity of LTK is sufficient to promote neurite outgrowth through pathways that include reactions catalyzed by phosphatidylinositol 3-kinase and MAPK. NeuroReport 19:1733-1738 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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