Article
Neurosciences
Elodie Bertrand, Eelco van Duinkerken, Jerson Laks, Marcia Cristina Nascimento Dourado, Gabriel Bernardes, Jesus Landeira-Fernandez, Daniel C. Mograbi
Summary: The study found that extensive regions of the brain are linked to self-awareness, with particular frontal and temporal alterations leading to unawareness, in agreement with theoretical models indicating executive and mnemonic forms of anosognosia in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Shuai Guan, Xiangyu Kong, Shifei Duan, Qingguo Ren, Zhaodi Huang, Ye Li, Wei Wang, Gaolang Gong, Xiangshui Meng, Xiangxing Ma
Summary: The study found that specific structural and functional anomalies exist in gray matter regions in community-dwelling asymptomatic adults with very early-stage WMH, but no global white matter changes were observed.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Antoine Garnier-Crussard, Salma Bougacha, Miranka Wirth, Sophie Dautricourt, Siya Sherif, Brigitte Landeau, Julie Gonneaud, Robin De Flores, Vincent de la Sayette, Denis Vivien, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) in Alzheimer's disease (AD), especially in the splenium of the corpus callosum (S-CC), are associated with decreased cognition independently from amyloid deposition and atrophy. This study highlights the clinical relevance of posterior WMH, particularly S-CC WMH, in AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Maurizio Bergamino, Ryan R. Walsh, Ashley M. Stokes
Summary: Standard DTI and FW-DTI both showed decreased FA in AD, but higher AxD and RD were observed with standard DTI. The FW index was significantly elevated in AD, emphasizing the impact of free water on standard DTI in neurodegenerative pathologies. FW-DTI provided improved consistency in DTI metrics related to WM integrity in Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Si-ping Luo, Fan-fan Chen, Han-wen Zhang, Fan Lin, Guo-dong Huang, Yi Lei
Summary: This study used DSI to quantitatively study the changes in the trigeminal cistern segment in patients with TN and found significant reductions in quantitative parameters on the affected side compared to the unaffected side. DSI, with its high-resolution fiber tracking technology, can provide valuable information about the integrity of trigeminal white matter in TN patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Zhiyu Cao, Yingren Mai, Wenli Fang, Ming Lei, Yishan Luo, Lei Zhao, Wang Liao, Qun Yu, Jiaxin Xu, Yuting Ruan, Songhua Xiao, Vincent C. T. Mok, Lin Shi, Jun Liu
Summary: This study explored the association between white matter hyperintensities (WMHs) and regional brain lobe atrophy in patients with Alzheimer's disease (AD). The results showed that the severity of WMHs tends to be associated with atrophy in specific brain regions, especially in the medial temporal lobe, temporal lobe, and insular lobe. Periventricular WMHs contributed to these correlations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Preeti Kar, Jess E. Reynolds, Melody N. Grohs, Rhonda C. Bell, Megan Jarman, Deborah Dewey, Catherine Lebel
Summary: This study found that breastfeeding exclusivity and duration were associated with global and regional white matter microstructure in young children, even after controlling for perinatal and sociodemographic factors. Greater exclusivity was linked to higher fractional anisotropy in females and lower in males.
Article
Clinical Neurology
Anna Dewenter, Mina A. Jacob, Mengfei Cai, Benno Gesierich, Paul Hager, Anna Kopczak, Davina Biel, Michael Ewers, Anil M. Tuladhar, Frank-Erik De Leeuw, Martin Dichgans, Nicolai Franzmeier, Marco Duering
Summary: Fixel-based analysis of diffusion MRI can identify changes in white matter integrity. Neurodegeneration in Alzheimer's disease affects white matter macrostructure, while cerebral small vessel disease affects white matter microstructure. Fiber density reflects the impact of cerebral small vessel disease, while fiber-bundle cross-section is primarily determined by neurodegeneration.
Article
Neurosciences
Sher Li Oh, Chiung-Mei Chen, Yih-Ru Wu, Maria Valdes Hernandez, Chih-Chien Tsai, Jur-Shan Cheng, Yao-Liang Chen, Yi-Ming Wu, Yu-Chun Lin, Jiun-Jie Wang
Summary: Microstructure damage in white matter is linked to atrophy in Huntington's Disease, with degeneration of subcortical regions associated with damage of white matter tracts. Fixel-based analysis is effective in studying these microstructural changes in white matter tracts in HD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Mahsa Dadar, Sawsan Mahmoud, Maryna Zhernovaia, Richard Camicioli, Josefina Maranzano, Simon Duchesne
Summary: There are distinct differences in WMH prevalence and distribution across different neurodegenerative disorders, as well as differences between sexes and asymmetry in WMH burden. The study found that women tend to have lower WMH burden compared to men and there are differences in WMH volumes between the left and right brain lobes.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Katherine J. Bangen, Kelsey R. Thomas, Danielle L. Sanchez, Emily C. Edmonds, Alexandra J. Weigand, Lisa Delano-Wood, Mark W. Bondi
Summary: This study examined the association between cerebral blood flow (CBF) and memory performance, brain structure, and white matter hyperintensity volume. Lower baseline entorhinal CBF was found to predict faster decline in memory, as well as faster entorhinal thinning and WMH progression. However, hippocampal CBF did not predict cognitive or brain structure trajectories.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuan Sun, Cui Zhao, Si-Yu Chen, Yan Chang, Yu-Liang Han, Ke Li, Hong-Mei Sun, Zhen-Fu Wang, Ying Liang, Jian-Jun Jia
Summary: This study validates the potential of FW-DTI indices as biomarkers of AD and demonstrates the good accuracy of FW-DTI in classifying MCI subtypes. There is a significant association between FW-DTI indices and memory and visuospatial function.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Mark R. Etherton, Ona Wu, Anne-Katrin Giese, Natalia S. Rost
Summary: In this study of 319 patients with acute ischemic stroke, it was found that normal-appearing white matter axial diffusivity increases with age and independently predicts white matter hyperintensity volume. Increasing age and admission diastolic blood pressure were also identified as independent predictors of normal-appearing white matter axial diffusivity.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Geriatrics & Gerontology
Alexis A. Bender, Rebecca L. McIntosh, Sean Sudduth, Michaela Harris, Kathy Tuckey, John C. Morgan, Joanna M. Jungerman, Abby Cox, Miranda A. Moore, Bryshia Ingram, Ellyn Pier, Theodore M. Johnson, David W. Loring, Kenneth Hepburn, Laura Medders, Allan Levey, James J. Lah, Chadwick M. Hales
Summary: GMN is an innovative care model aimed at improving access to accurate and timely diagnosis for patients with memory loss. It may help enhance the quality of life for patients and families through preventive and early care.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Neurosciences
Erik C. B. Johnson, E. Kathleen Carter, Eric B. Dammer, Duc M. Duong, Ekaterina S. Gerasimov, Yue Liu, Jiaqi Liu, Ranjita Betarbet, Lingyan Ping, Luming Yin, Geidy E. Serrano, Thomas G. Beach, Junmin Peng, Philip L. De Jager, Vahram Haroutunian, Bin Zhang, Chris Gaiteri, David A. Bennett, Marla Gearing, Thomas S. Wingo, Aliza P. Wingo, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Summary: This study analyzed the proteomes of over 1,000 brain tissues and identified new protein co-expression modules associated with Alzheimer's disease. These modules were highly conserved across cohorts and brain regions and revealed a proteopathic nature of the disease. The study also found disease-associated modules unique to the proteome, which could serve as potential therapeutic targets and biomarkers for Alzheimer's disease.
NATURE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lei Yu, Patricia A. Boyle, Aliza P. Wingo, Jingyun Yang, Tianhao Wang, Aron S. Buchman, Thomas S. Wingo, Nicholas T. Seyfried, Allan Levey, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Summary: The cortical proteins implicated in Alzheimer's dementia were found to be more associated with non-AD neurodegenerative and cerebrovascular conditions rather than AD pathology. Some proteins were found to be pleiotropic and associated with both neurodegenerative and cerebrovascular pathologies.
Article
Psychiatry
Aliza P. Wingo, Mengli Wang, Jiaqi Liu, Michael S. Breen, Hyun-Sik Yang, Beisha Tang, Julie A. Schneider, Nicholas T. Seyfried, James J. Lah, Allan Levey, David A. Bennett, Peng Jin, Philip L. De Jager, Thomas S. Wingo
Summary: This study identified miR-29a-3p and miR-132-3p as novel and independent contributors to cognitive trajectory in older adults. These microRNAs have a significant impact on cognitive performance and are not influenced by common neurodegenerative pathologies. Additionally, the findings provide a foundation for future studies to explore the mechanisms and interventions to enhance cognitive stability in advanced age.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Antoine Hone-Blanchet, Anastasia Bohsali, Lisa C. Krishnamurthy, Salman S. Shahid, Qixiang Lin, Liping Zhao, Aditya S. Bisht, Samantha E. John, David Loring, Felicia Goldstein, Allan Levey, James Lah, Deqiang Qiu, Bruce Crosson
Summary: The study revealed an association between frontal GABA+ levels and neurological aging, with GABA+ levels being reduced in MCI patients. Additionally, N-acetylaspartate relative to myo-inositol (tNAA/mI) predicted cognition in MCI patients only and was not related to CSF biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Aron S. Buchman, Lei Yu, Hans-Ulrich Klein, Andrea R. Zammit, Shahram Oveisgharan, Francine Grodstein, Shinya Tasaki, Allan Levey, Nicholas T. Seyfried, David A. Bennett
Summary: This study identified cortical proteins that may provide motor resilience in older adults. Five proteins were associated with progressive parkinsonism, suggesting their potential as therapeutic targets for maintaining motor function despite untreatable brain pathologies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thomas S. Wingo, Ekaterina S. Gerasimov, Yue Liu, Duc M. Duong, Selina M. Vattathil, Adriana Lori, Jake Gockley, Michael S. Breen, Adam X. Maihofer, Caroline M. Nievergelt, Karestan C. Koenen, Daniel F. Levey, Joel Gelernter, Murray B. Stein, Kerry J. Ressler, David A. Bennett, Allan Levey, Nicholas T. Seyfried, Aliza P. Wingo
Summary: This study identified 11 genes that contribute to the pathogenesis of PTSD by regulating brain protein abundance. Seven of these genes were replicated in further studies and four also showed association with PTSD at the brain mRNA level. These findings provide promising targets for mechanistic and therapeutic studies for PTSD.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Sruti Rayaprolu, Sara Bitarafan, Juliet Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor Janos Olah, Matt Rowan, Allan Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Summary: By using cell type-specific protein labeling, we can better study the proteomic differences between neurons and astrocytes, and identify potential factors related to neurological diseases.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie, Yunhao Zhai, Roey Lazarovits, Adam Mansour, Min Sun Kim, Aditya Patil, Danielle Curran, Jaclyn M. Long, Sanjay Sharma, Abidemi Junaid, Limor Cohen, Thomas C. Ferrante, Oren Levy, Rachelle Prantil-Baun, David R. Walt, Donald E. Ingber
Summary: In this study, researchers successfully cultured human ectopic lymphoid follicles with similar characteristics to lymphoid follicles in a microfluidic chip. These follicles showed improved immune responses to vaccines and can serve as an alternative to non-human primates for preclinical evaluation.
Article
Clinical Neurology
Thomas S. Wingo, Ekaterina S. Gerasimov, Se Min Canon, James J. Lah, Allan Levey, Aliza P. Wingo
Summary: The study found that depression manifesting after age 50 is associated with a genetic predisposition to Alzheimer's disease (AD), suggesting that genetic predisposition may be a factor contributing to the pathogenesis of mid-life depression. Further study is needed to investigate whether there is a shared genetic basis between mid-life depression and AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Richa Batra, Matthias Arnold, Maria A. Woerheide, Mariet Allen, Xue Wang, Colette Blach, Allan Levey, Nicholas T. Seyfried, Nilufer Ertekin-Taner, David A. Bennett, Gabi Kastenmuller, Rima F. Kaddurah-Daouk, Jan Krumsiek
Summary: This study provides a comprehensive investigation and description of AD-associated metabolic changes, laying the foundation for future mechanistic research.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Aliza P. Wingo, Selina M. Vattathil, Jiaqi Liu, Wen Fan, David J. Cutler, Allan Levey, Julie A. Schneider, David A. Bennett, Thomas S. Wingo
Summary: This study found that LDL-C is associated with various neuropathological manifestations of AD independent of APOE, suggesting that LDL-C may be a modifiable risk factor for AD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Caroline M. Watson, Eric B. Dammer, Lingyan Ping, Duc M. Duong, Erica Modeste, E. Kathleen Carter, Erik C. B. Johnson, Allan I. Levey, James J. Lah, Blaine R. Roberts, Nicholas T. Seyfried
Summary: Alzheimer's disease (AD) is the most common form of dementia, and CSF beta-amyloid, total Tau, and phosphorylated Tau (pTau) are sensitive and specific biomarkers for diagnosis. However, these biomarkers do not capture the complex changes in AD brain beyond amyloid and Tau pathologies. This study used SRM-MS with isotopically labeled standards to quantify CSF protein biomarkers, identifying proteins that could distinguish AD stages and cognitive impairment.
Article
Multidisciplinary Sciences
Zifan Jiang, Salman Seyedi, Rafi U. Haque, Alvince L. Pongos, Kayci L. Vickers, Cecelia M. Manzanares, James J. Lah, Allan I. Levey, Gari D. Clifford
Summary: This study utilized a computer vision-based deep learning model to analyze facial emotions expressed by individuals with cognitive impairment. The findings show that cognitive impairment is associated with differences in facial emotion expression, which can be used as an effective tool for screening cognitive impairment.