Article
Psychology, Multidisciplinary
Wen Lin Teh, Jianlin Liu, Nisha Chandwani, Yu Wei Lee, Phern-Chern Tor, Mythily Subramaniam, Roger C. Ho
Summary: This study aimed to establish the clinical relevance of emotional urgency in bipolar disorders. The results showed that emotional urgency had a significant impact on bipolar symptoms, while non-emotional impulsivity subdimensions had smaller effects and were not significant factors in the regression models. Additionally, individuals with a history of attempted suicide had higher levels of emotional urgency.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Anna L. Horton, Erin J. Campbell, Timothy D. Aumann, Katrina R. O'Brien, Andrew J. Lawrence, Robyn M. Brown
Summary: Compulsive overeating of palatable food is related to obesity, and similarities have been found in the behavioral symptomology and neuropathophysiology between substance use disorder and compulsive overeating. Animal models can help understand the neurobiology underlying overeating behavior. This study investigated the relationship between addiction-like behavior towards highly palatable food and diet-induced obesity (DIO) in C57BL/6 J mice. The results suggest that the 3-criteria model is a robust tool for assessing food addiction-like behavior in mice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
A. Garcia-Blanco, A. Ramirez-Lopez, F. Navarrete, M. S. Garcia-Gutierrez, J. Manzanares, E. Martin-Garcia, R. Maldonado
Summary: The endocannabinoid system plays a crucial role in behavioral responses in the central nervous system. The cannabinoid CB1 receptor is associated with loss of behavioral control during food addiction, while the CB2 receptor is linked to addictive-like behavior and drug addiction. In this study, the specific role of CB2R in food addiction was evaluated using an operant mouse model. It was found that the lack of CB2R provides protection against the development of food addiction and associated impulsive and depressive-like behavior, while overexpression of CB2R increases vulnerability to food addiction. Transcriptomic changes were also observed, providing mechanistic explanations for these behavioral changes. Therefore, CB2R may serve as a potential therapeutic target for regulating eating control and managing emotional effects in food addiction.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Psychology, Multidisciplinary
Lucy Hitcham, Hannah Jackson, Richard J. E. James
Summary: There is a lack of strong correlation between measurements of smartphone addiction and actual behavior logged from smartphones. This study suggests that perceived smartphone usage, rather than actual usage, is the main driver of smartphone addiction. Self-reported smartphone usage, other behavioral addictions, and negative urgency are more predictive of smartphone addiction than logged behavior.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Vivek M. Philip, Hao He, Michael C. Saul, Price E. Dickson, Jason A. Bubier, Elissa J. Chesler
Summary: This study used RNA-Seq to analyze transcript abundance in the striatum of mice and identified genetic variants through eQTL mapping that affect gene expression levels. The results provided a data resource for constructing an eQTL viewer and co-expression network, allowing researchers to analyze specific genes, SNP associations, gene expression correlations, and mediation analysis. This resource helps identify genetic variants that regulate differentially expressed genes and provides context for addiction-related behavior studies.
Article
Psychology, Multidisciplinary
Dilek Demir, Murat Bektas, Senay Demir, Ilknur Bektas
Summary: This study assessed the psychometric properties of the Turkish version of the Addiction-Like Eating Behavior Scale for university students, with a sample of 884 students. The results showed that the scale is a valid and reliable tool for this population, with factor analysis and reliability tests providing strong support for its use.
CURRENT PSYCHOLOGY
(2021)
Article
Biology
Jared R. Bagley, Yalun Tan, Wan Zhu, Zhuanfen Cheng, Saori Takeda, Zhouqing Fang, Ahmed Arslan, Meiyue Wang, Yuan Guan, Lihua Jiang, Ruiqi Jian, Feng Gu, Isabel Parada, David Prince, J. David Jentsch, Gary Peltz
Summary: Genetic variation plays a significant role in the risk of substance use disorder, but the specific genetic factors and mechanisms are mostly unknown. This study suggests that Nav1, a gene involved in dendrite formation and axonal guidance, may be associated with cocaine addiction. Knockout mice lacking Nav1 demonstrated an increased voluntary cocaine intake and motivation for cocaine consumption. Molecular analysis revealed changes in synaptic balance in the cortex and hippocampus of Nav1 knockout mice, potentially contributing to cocaine addiction.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Jared R. Bagley, Yalun Tan, Wan Zhu, Zhuanfen Cheng, Saori Takeda, Zhouqing Fang, Ahmed Arslan, Meiyue Wang, Yuan Guan, Lihua Jiang, Ruiqi Jian, Feng Gu, Isabel Parada, David Prince, J. David Jentsch, Gary Peltz
Summary: Genetic variation plays a significant role in the development of substance use disorders. By analyzing cocaine self-administration data from inbred mouse strains, Nav1, a member of the neuron navigator family, was identified as a candidate gene. Knockout mice lacking Nav1 showed increased voluntary cocaine intake, and further investigations revealed altered excitatory and inhibitory synaptic balance in the cortex and hippocampus.
COMMUNICATIONS BIOLOGY
(2023)
Article
Psychiatry
Ekin Soenmez Guengoer, Cengiz Celebi, Yildiz Akvardar
Summary: The study found that food addiction is significantly associated with more serious eating pathologies, more frequent weight-cycling, higher impulsivity, and higher BMI. The severity of food addiction was predictive of an increase in BMI. Impulsivity showed a correlation with the severity of food addiction, suggesting a relationship between impulsivity and weight gain in some individuals.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Laura Marie Sommer, Georg Halbeisen, Yesim Erim, Georgios Paslakis
Summary: This study compared OB-BED patients with OB individuals and healthy controls in terms of psychopathological features, eating-related phenotypes, and early life experiences. The results showed that OB-BED patients had the highest scores across multiple assessments and significant differences from OB individuals and healthy controls, indicating important distinctions between these groups.
Article
Multidisciplinary Sciences
Jeffrey S. Stein, Gregory J. Madden
Summary: The method of choice bundling can increase preference for larger, later rewards and this effect is more pronounced with a higher number of rewards in the bundle. Descending bundle order may lead to greater preference for larger rewards. The effects of choice bundling align with predictions of an additive model of hyperbolic delay discounting.
Review
Clinical Neurology
Chloe Kidd, Natalie J. Loxton
Summary: Adolescence is characterized by heightened reward drive and weaker inhibitory control, which may increase vulnerability to compulsive overconsumption of highly-palatable foods and food addiction. Impulsivity traits (reward sensitivity and rash impulsivity) were found to be associated with food addiction in adolescents, with mixed relationships between reward sensitivity and food addiction. Longitudinal and prospective research is recommended to further confirm these findings and investigate potential interactive effects of reward sensitivity and rash impulsivity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Cheng-Yi Huang, Chia-Chun Hung, Yu-Juan Ho, Su-Chen Fang
Summary: This study explored the relationship between early cigarette smoking initiation, trait impulsivity, and methamphetamine addiction severity. It found that early smoking initiation may lead to higher addiction severity through the mediating effect of impulsivity. This highlights the need for prevention efforts targeting vulnerable populations and the integration of impulsivity-focused interventions for individuals with methamphetamine use disorder.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2022)
Article
Psychiatry
Pierluigi Diotaiuti, Stefania Mancone, Stefano Corrado, Alfredo De Risio, Elisa Cavicchiolo, Laura Girelli, Andrea Chirico
Summary: Excessive Internet use is associated with psychological symptoms and psychiatric disorders. This study found that impulsivity and codependency are predictors of Internet addiction. Male participants showed higher levels of dependency, impulsivity, and codependency, which increased with age.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Travis M. Moschak, T. Joseph Sloand, Regina M. Carelli
Summary: Distress tolerance (DT) is the ability to persist in challenging goal-directed behavior in the face of stress. Preclinical study in rats reveals that low DT is associated with heightened drug-seeking behavior. The study also demonstrates that the prelimbic cortex (PrL) plays an important role in DT and drug-seeking behavior, particularly in male rats with a history of cocaine.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Antonio Ferragud, Clara Velazquez-Sanchez, Margaret A. Minnig, Valentina Sabino, Pietro Cottone
Summary: Alcohol use disorder (AUD) is a devastating illness characterized by heavy drinking and withdrawal. Chronic intermittent exposure to ethanol activates the PACAP/PAC1R system in the bed nucleus of the stria terminalis, leading to increased alcohol intake and anxiety-like behavior during withdrawal.
NEUROPSYCHOPHARMACOLOGY
(2021)
Editorial Material
Behavioral Sciences
Maria A. Aguilar, Nazzareno Cannella, Antonio Ferragud, Rainer Spanagel
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chiara Giuliano, Mickael Puaud, Rudolf N. Cardinal, David Belin, Barry J. Everitt
Summary: Excessive drinking is a key characteristic of alcohol addiction, but individuals addicted to alcohol also crave and seek alcohol despite negative consequences, eventually leading to intoxication. Habitual alcohol seeking behavior is associated with compulsive alcohol drinking, indicating the involvement of the habit system in the development of alcohol addiction.
Article
Substance Abuse
Sema G. Quadir, Sean M. Tanino, Yasmine N. Sami, Margaret A. Minnig, Malliga R. Iyer, Kenner C. Rice, Pietro Cottone, Valentina Sabino
Summary: The study found that the Sig-1R antagonist BD-1063 dose-dependently reduced alcohol intake and preference, as well as reversed alcohol-induced hyperalgesia, providing a foundation for the development of novel treatments for AUD and associated pain states.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alexander C. W. Smith, Sietse Jonkman, Alexandra G. Difeliceantonio, Richard M. O'Connor, Soham Ghoshal, Michael F. Romano, Barry J. Everitt, Paul J. Kenny
Summary: The study showed that neural activity increases in the anterior dorsolateral striatum when mice successfully learn a new lever-press response, indicating that D1-MSNs encode new instrumental actions while D2-MSNs promote the expression of habitual actions. Disruption of D1-MSNs inhibits the consolidation process, whereas inhibition of D2-MSNs strengthens consolidation but blocks the expression of previously learned habit-like responses.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Catherine F. Moore, Elise M. Weerts
Summary: The study examined the effects of orally administered THC and CBD on pain sensitivity, body temperature, locomotor activity, and catalepsy in rats. THC produced long lasting effects of antinociception, hypothermia, hyper- and hypolocomotion, and catalepsy, while CBD had modest effects on pain sensitivity and sex-dependent effects on body temperature and locomotor activity.
PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Daria Piacentino, Silvia Grant-Beurmann, Carlotta Vizioli, Xiaobai Li, Catherine F. Moore, Victor Ruiz-Rodado, Mary R. Lee, Paule Joseph, Claire M. Fraser, Elise M. Weerts, Lorenzo Leggio
Summary: This study reveals that long-term heavy alcohol consumption can affect the gut microbiome and metabolome in baboons, leading to decreased microbial diversity, changes in specific bacterial families, and increased metabolites related to energy metabolism. Even after short-term abstinence, some of these changes may not fully reverse.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Biological
Catherine F. Moore, Catherine M. Davis, Cristina Sempio, Jost Klawitter, Uwe Christians, Elise M. Weerts
Summary: A well-documented side effect of cannabis and THC is deficits in cognition and attention. Cannabidiol (CBD) may modulate THC's impairing effects. This study found that THC alone decreased accuracy and increased lapses in attention, while coadministration of CBD with THC caused greater impairments to sustained attention.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bryan W. Jenkins, Catherine F. Moore, Dan Covey, Jacob D. McDonald, Timothy W. Lefever, Marcel O. Bonn-Miller, Elise M. Weerts
Summary: This study evaluated the effects of minor cannabinoids and terpenes in tests sensitive to anxiety. The results suggest that some minor cannabinoids and terpenes may have anxiolytic properties.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Catherine F. Moore, Julie Marusich, Mehdi Haghdoost, Timothy W. Lefever, Marcel O. Bonn-Miller, Elise M. Weerts
Summary: This study found that the minor cannabinoids and terpenes in cannabis have little effect on the interoceptive effects of D9-THC, suggesting that they are unlikely to lower the psychoactive effects of D9-THC in human users.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Catherine F. Moore, Elise M. Weerts, Justyna Kulpa, Daniela Schwotzer, Wendy Dye, Jacob Jantzi, Jacob D. McDonald, Timothy W. Lefever, Marcel O. Bonn-Miller
Summary: This study examined the pharmacokinetics of four minor cannabinoids (THCV, CBC, CBN, and D8-THC) after repeated oral dosing. The results showed detectable levels of these cannabinoids in plasma and their translocation to brain tissue. D8-THC exhibited the highest dose-normalized Cmax and AUClast. The concentration of THCV was lower on day 14, indicating potential adaptation and increased drug elimination. These findings are important for determining target dose ranges and dosing schedules in future studies evaluating the potential effects of these compounds.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Catherine F. Moore, Catherine M. Davis, Cristina Sempio, Jost Klawitter, Uwe Christians, Elise M. Weerts
Summary: This study demonstrates the conditioned rewarding effects of THC vapor in both male and female rats and provides evidence for sex differences in amounts of THC vapor that produce conditioned place preference and in time to extinction.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Review
Behavioral Sciences
Catherine F. Moore, Jeffrey W. Stiltner, Catherine M. Davis, Elise M. Weerts
Summary: This review focuses on the emerging field of preclinical vapor models, specifically examining cannabinoid exposure. It summarizes vapor exposure parameters and other methodological details, discusses the pharmacological and behavioral effects of vaporized cannabinoids, and compares the behavioral effects of cannabinoid vapor administration with other routes of administration. This review serves as a guide for current and future research in vapor delivery methods in animals.
BEHAVIOURAL PHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Catherine Moore, Catherine Davis, Elise Weerts
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Catherine Moore, Mary Lee, Elise Weerts