Article
Anesthesiology
Shathish Kumar, Ramasamy Kesavan, Sarath Chandra Sistla, Prasanth Penumadu, Harivenkatesh Natarajan, Sreekumaran Nair, Uppugunduri Chakradhara S. Rao, Vasuki Venkatesan, Pankaj Kundra
Summary: This study evaluated the association between 10 candidate SNPs in 9 genes and postoperative fentanyl dose, pain scores, and time for first analgesia. The results showed that certain SNPs were associated with higher fentanyl requirement and higher pain scores, while other SNPs were associated with lower pain scores and shorter time for first analgesia.
ANESTHESIA AND ANALGESIA
(2023)
Article
Allergy
Kaori Kawakami, Tomomitsu Miyasaka, Yutaka Nakamura, Hirohito Metoki, Satoshi Miyata, Miki Sato, Ichiro Sora, Kohei Yamauchi, Kazuyoshi Kawakami, Julie A. Blendy, Tasuku Kawano, Hiroaki Shimokawa, Motoaki Takayanagi, Isao Ohno, Tomoko Takahashi
Summary: This study found that asthma patients carrying the OPRM1 GG genotype exhibit enhanced airway hyperresponsiveness in the absence of forced stress exposure, possibly due to enhanced Th2 cell differentiation in regional lymph nodes. Naloxone methiodide injection can reduce Th2 cell increase and eosinophil elevation in GG mice, bringing them back to the levels seen in AA mice.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Neurosciences
Pei-Shan Hsu, Chou-Ming Cheng, Hsiang-Tai Chao, Ming-Wei Lin, Wei-Chi Li, Lin-Chien Lee, Ching-Hsiung Liu, Li-Fen Chen, Jen-Chuen Hsieh
Summary: The study aims to explore the potential relationship between the OPRM1 A118G polymorphism and changes in white matter in young women with primary dysmenorrhea (PDM). The results show that G allele carriers have higher fractional anisotropy (FA) and lower radial diffusivity in the corpus callosum and the left corona radiata compared to AA homozygotes during the menstrual phase. Additionally, the mean FA of the corpus callosum and the corona radiata is negatively correlated with pain experience in AA homozygotes, but not in G allele carriers.
FRONTIERS IN NEUROSCIENCE
(2023)
Letter
Psychiatry
Alfonso Troisi
Summary: Research suggests that variation in the mu-opioid receptor gene is linked to attachment behavior in adults, with the A118G polymorphism and early maternal care interacting to influence levels of fearful attachment. Individuals carrying the minor 118G allele experience more pleasure in social situations and show lower levels of avoidant attachment compared to those with the A/A genotype.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Orna Levran, Mary Jeanne Kreek
Summary: The study aimed to determine the genetic background of the OPRM1 region 118G and its potential modulatory effect. Seven common haplotypes with distinct population distribution were identified, with some containing additional regulatory SNPs that may modulate the effect of 118G. Further analysis revealed specific genetic backgrounds in different populations, highlighting the need for specific experimental approaches to differentiate between the effects of 118G and other SNPs.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Erawan Borkham-Kamphorst, Ute Haas, Manuela Pinoe-Schmidt, Ali T. Abdallah, Ralf Weiskirchen
Summary: Our study revealed that LCN2 plays an important role in chronic inflammation and fibrosis, with levels correlating with hepatic inflammation rather than fibrosis. Chronic mineral-oil administration induces hepatic inflammation through innate immune responses via myeloid cell activation. Lcn2 null mice exhibit less inflammation due to defective genes involved in myeloid cell activation, leading to mitigation of liver fibrosis.
LABORATORY INVESTIGATION
(2021)
Article
Psychology, Biological
Joanna B. Thompson, Alan M. Daniel, Brenda G. Rushing, Mauricio R. Papini
Summary: In this study, animals exhibited transient rejection of reward after a reward downshift, followed by training in an operant licking task. The speed of recovery from the reward downshift was found to be associated with performance in the operant licking task, but not with genetic variations in the opioid receptor gene OPRM1.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Amina M. Bagher, Rawan H. Hareeri
Summary: The study aimed to assess the allele frequency and genotype distribution of OPRM1 A118G SNP in Saudis. The results showed a low prevalence of the OPRM1 A118G polymorphism in the Saudi population, with a higher frequency of the 118G allele in females.
JOURNAL OF APPLIED BIOMEDICINE
(2023)
Article
Medicine, General & Internal
Hongzhen Cheng, Xiaoyan Chu, Shenghua Yi
Summary: This study demonstrated the significant influence of OPRM1 A118G genotype on the dosage of morphine in advanced liver cancer patients, with GG genotype patients requiring higher morphine doses for pain control.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Neurosciences
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
Summary: By introducing the Oprm1-Cre knock-in transgenic rat, this study investigated the role of the mu-opioid receptor (MOR) in heroin self-administration. The study found that heroin self-administration showed different patterns in male and female Oprm1-Cre rats. This research provides new strategies for understanding the involvement of MOR-expressing cells in opioid addiction, pain-related behaviors, and other opioid-mediated functions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Min Xie, Chen-Yu Tsai, Zachary L. L. McAdams, Myo Oo, Mark Hansen, Maureen Dougher, Alexander Sansano, Anderson Watson, Katherine LoMauro, Rosleine Antilus-Sainte, Aaron Ericsson, Veronique Dartois, Martin Gengenbacher
Summary: Recent studies have shown that the gut microbiota of wild mice improves host fitness and disease resistance. This study examined whether the gut microbiota of wild mice affects the immune pathology of TB in BALB/c mice. The results showed that mice with the gut microbiota of wild mice controlled initial TB infection better than conventional lab mice.
Article
Multidisciplinary Sciences
Min Xie, Chen-Yu Tsai, Zachary L. McAdams, Myo Oo, Mark Hansen, Maureen Dougher, Alexander Sansano, Anderson Watson, Katherine LoMauro, Rosleine Antilus-Sainte, Aaron Ericsson, Veronique Dartois, Martin Gengenbacher
Summary: This study investigates the impact of wild mouse gut microbiota on the immunopathology of tuberculosis (TB) in BALB/c mice. The results show that mice with wild mouse gut microbiota have better control of initial TB infection compared to conventional mice. The gut microbial community composition is altered by TB infection, causing dysbiosis. The wild mouse gut microbiota does not affect the typical lung histopathology of TB, but there are differences in T cell response and pathogen load between the two groups.
Article
Hematology
Sven Stockhausen, Badr Kilani, Irene Schubert, Anna-Lena Steinsiek, Sue Chandraratne, Franziska Wendler, Luke Eivers, Marie-Luise von Bruehl, Steffen Massberg, Ilka Ott, Konstantin Stark
Summary: Chronic EPO overproduction significantly increases the risk of DVT, while short-term EPO treatment does not. Red blood cells have a pronounced prothrombotic effect on DVT, which is not influenced by splenic RBC clearance.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Rienke F. Uijen, Lucille F. van Beek, Fred van Opzeeland, Elles Simonetti, Saskia van Selm, Olivia Bonduelle, Behazine Combadiere, Jeroen D. Langereis, Marien I. de Jonge
Summary: Intradermal vaccination was found to be inferior to intramuscular immunization in inducing serotype-specific antibodies against the 13-valent pneumococcal conjugate vaccine (PCV13). The antibody levels in both serum and mucosal samples were higher in the intramuscularly vaccinated group. Neither vaccination route provided protection against nasally colonized S. pneumoniae.
Article
Neurosciences
Eden M. Anderson, Annabel Engelhardt, Skyler Demis, Elissa Porath, Matthew C. Hearing
Summary: The study demonstrates that self-administration of the potent opioid remifentanil leads to a long-lasting hypoactive basal state in the medial prefrontal cortex, with distinct effects and mechanisms observed in males and females.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Marta Valenza, Roberto Picetti, Vadim Yuferov, Eduardo R. Butelman, Mary Jeanne Kreek
Article
Environmental Sciences
Jonathon Taylor, Paul Wilkinson, Roberto Picetti, Phil Symonds, Clare Heaviside, Helen L. Macintyre, Michael Davies, Anna Mavrogianni, Emma Hutchinson
ENVIRONMENT INTERNATIONAL
(2018)
Article
Environmental Sciences
H. L. Macintyre, C. Heaviside, J. Taylor, R. Picetti, P. Symonds, X. -M. Cai, S. Vardoulakis
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Cell Biology
Emanuele Tirotta, Valerie Fontaine, Roberto Picetti, Monica Lombardi, Tarek A. Samad, Mustafa Oulad-Abdelghani, Robert Edwards, Emiliana Borrelli
Article
Pharmacology & Pharmacy
R. Picetti, S. D. Schlussman, Y. Zhou, B. Ray, E. Ducat, V. Yuferov, M. J. Kreek
CURRENT PHARMACEUTICAL DESIGN
(2013)
Article
Neurosciences
Covadonga Paneda, Salvador Huitron-Resendiz, Laura M. Frago, Julie A. Chowen, Roberto Picetti, Luis de Lecea, Amanda J. Roberts
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Yong Zhang, Roberto Picetti, Eduardo R. Butelman, Stefan D. Schlussman, Ann Ho, Mary Jeanne Kreek
NEUROPSYCHOPHARMACOLOGY
(2009)
Article
Neurosciences
Roberto Picetti, Ann Ho, Eduardo R. Butelman, Mary Jeanne Kreek
PSYCHOPHARMACOLOGY
(2010)
Article
Neurosciences
Roberto Picetti, Jilda A. Caccavo, Ann Ho, Mary Jeanne Kreek
PSYCHOPHARMACOLOGY
(2012)
Review
Hematology
Roberto Picetti, Haleema Shakur-Still, Robert L. Medcalf, Joseph F. Standing, Ian Roberts
BLOOD COAGULATION & FIBRINOLYSIS
(2019)
Article
Obstetrics & Gynecology
Roberto Picetti, Lori Miller, Haleema Shakur-Still, Tracey Pepple, Danielle Beaumont, Eni Balogun, Etienne Asonganyi, Rizwana Chaudhri, Mohamed El-Sheikh, Bellington Vwalika, Sabaratnam Arulkumaran, Ian Roberts
BMC PREGNANCY AND CHILDBIRTH
(2020)
Article
Anesthesiology
Stanislas Grassin-Delyle, Haleema Shakur-Still, Roberto Picetti, Lauren Frimley, Heather Jarman, Ross Davenport, William McGuinness, Phil Moss, Jason Pott, Nigel Tai, Elodie Lamy, Saik Urien, Danielle Prowse, Andrew Thayne, Catherine Gilliam, Harvey Pynn, Ian Roberts
Summary: The study demonstrates that intramuscular TXA is well tolerated and rapidly absorbed in bleeding trauma patients. A two-compartment open model best describes the pharmacokinetic characteristics of TXA, with therapeutic concentrations reached within 4 to 11 minutes for a 70-kg patient.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Review
Environmental Sciences
Roberto Picetti, Megan Deeney, Silvia Pastorino, Mark R. Miller, Anoop Shah, David A. Leon, Alan D. Dangour, Rosemary Green
Summary: Water pollution from agricultural fertilizer use, particularly nitrate and nitrite contamination, is a concern for human health. This systematic review found an association between nitrate in drinking water and gastric cancer, but no association with other cancer sites. The research highlights the need for more robust studies on the health burden of nitrate contamination and the implementation of public policies to protect human health.
ENVIRONMENTAL RESEARCH
(2022)
Article
Veterinary Sciences
Molly Deutsch-Feldman, Roberto Picetti, Katharine Seip-Cammack, Yan Zhou, Mary Jeanne Kreek
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2015)