Article
Behavioral Sciences
Cristina Maria de Arruda, Diego Luiz Doneda, Vinicius Vezzi de Oliveira, Rozielly Aparecida Lemes da Silva, Yohan Alves Victor de Matos, Isadora Luiza Fernandes, Christopher Alecsander Herane Rohden, Giordano Gubert Viola, Fabricio Rios-Santos, Eliangela de Lima, Ziliani da Silva Buss, Samuel Vandresen-Filho
Summary: This study found that vilazodone has antidepressant-like effects, which may be mediated through an interaction with the kynurenine pathway and N-methyl-D-aspartate receptors.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Behavioral Sciences
Aida A. C. Brandao, Deborah L. S. Deus, Luiz A. M. S. Duarte-Filho, Pedro M. N. Menezes, Ana B. R. Massaranduba, Fabricio S. Silva, Luciano A. A. Ribeiro
Summary: Through nebulization delivery, ketamine can significantly reduce depressive-like behaviors in mice, indicating that nebulization can be an effective and inexpensive route of drug administration for behavioral research.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Gabriel Krasovec, Akiko Hozumi, Tomoyuki Yoshida, Takayuki Obita, Mayuko Hamada, Akira Shiraishi, Honoo Satake, Takeo Horie, Hisashi Mori, Yasunori Sasakura
Summary: D-Serine is involved in the modulation of glutamatergic transmission in mammalian central nervous system, while its functions in nonmammals are unclear. This study found that D-Serine is responsible for the release of epidermal vesicles during the metamorphosis of the tunicate Ciona. The formation of an epidermal pocket facilitated the migration of tissue during tail regression, and this mechanism is similar to keratinocyte vesicle exocytosis in mammalian skin.
Article
Behavioral Sciences
Josiane Budni, Morgana Moretti, Andiara E. Freitas, Vivian B. Neis, Camille M. Ribeiro, Grasiela de Oliveira Balen, Rodrigo B. Leal, Ana Lucia S. Rodrigues
Summary: This study found that folic acid can alleviate the depressive-like behavior induced by TNF-alpha, possibly through the activation of monoaminergic systems, inhibition of NMDA receptors and NO synthesis, as well as Akt modulation.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Genetics & Heredity
Amany Tawfik, Riyaz Mohamed, Dina Kira, Suhib Alhusban, Mohamed Al-Shabrawey
Summary: Elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with diabetic retinopathy (DR) and age-related macular degeneration (AMD). This study suggests that HHcy alters blood-retinal barrier (BRB) by activating N-methyl-D-aspartate receptor (NMDAR). Inhibition or elimination of NMDAR can potentially improve retinal hyperpermeability and morphology under HHcy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen, Akbar Shakoor, Ivana K. Kim, Margaret M. DeAngelis, Nader Sheibani, Mohamed Al-Shabrawey, Amany Tawfik
Summary: The study suggests that the activation of NMDAR in the retina pigment epithelium may be a mechanism for AMD induced by HHcy. Inhibition of NMDAR could be a promising therapeutic target for AMD, as knocking down RPE NMDAR improved retinal structure and CNV in mice with AMD-like features induced by HHcy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuka Takahashi, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, Chihiro Sato
Summary: Schizophrenia is a severe psychiatric disorder influenced by genetic and environmental factors. Changes in polysialylation of neural cell adhesion molecules have been found in the brains of patients with psychiatric disorders. This study investigates the effects of genetic (G) and environmental (E) factors on polysialylated NCAM expression using a schizophrenia mouse model and acute stress conditions. The study discovers differences in polysialylation and NCAM responses to stress in different brain regions, suggesting the vulnerability of the schizophrenia mouse model to stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Amanda J. Sales, Samia R. L. Joca, Elaine Del Bel, Francisco S. Guimaraes
Summary: Doxycycline, an antibiotic, has neuroprotective, anti-inflammatory, and antidepressant-like effects. It inhibits the synthesis of nitric oxide and reduces its levels in the prefrontal cortex, leading to rapid antidepressant-like effects in mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Pharmacology & Pharmacy
Ana Belen Ramos-Hryb, Francis L. Pazini, Ana Paula Costa, Mauricio P. Cunha, Manuella P. Kaster, Ana Lucia S. Rodrigues
Summary: The study discovered the crucial role of HO-1 in mediating the antidepressant-like effects of UA, and revealed a synergistic antidepressant effect when UA was combined with CoPP. Interestingly, fluoxetine did not show a significant correlation with the activity of HO-1.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Roberto Lovero, Cinzia Buccoliero, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
Summary: This study evaluated the potential antidepressant effects of irisin and found that it significantly reduced immobility time and displayed anxiolytic-like effects in mice. The study also identified potential molecular pathways underlying irisin's effects, including the upregulation of neurotrophic factors and modulation of cytokine expression. This research provides valuable insights for future preclinical studies on the use of irisin in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hong Chen, Suwei Chen, Haibo Zhang, Shengyu Wang, Yan Li, Xu Meng
Summary: This study investigated the specific mechanism of N-methyl-D-aspartate (NMDA) receptor-mediated spinal cord ischemia-reperfusion and compared the protective effects of nimodipine and K-1024 on the spinal cord. The results showed that K-1024 group had more normal motor neurons and better behavioral scores compared to the nimodipine and saline groups. In addition, K-1024 inhibited NMDA receptors and downregulated the protein expression level of nNOS, which indicated its potential in protecting against spinal cord ischemia-reperfusion injury.
FOLIA NEUROPATHOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Rohit Pal, Bhupinder Kumar, P. M. Guruubasavaraja Swamy, Pooja A. Chawla
Summary: A series of substituted-N-(5,6-diphenyl-1,2,4-triazin-3-yl) benzamides were designed, synthesized, and evaluated for their antidepressant-like activity. Compound R:5 and R:9 exhibited potent MAO-A inhibition activity and significant antidepressant effects in FST and TST. ADME and docking studies further confirmed their pharmacological characteristics and binding abilities.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Justin D. Yssel, Eoin O'Neill, Yvonne M. Nolan, Thomas J. Connor, Andrew Harkin
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Editorial Material
Immunology
Andrew Harkin, Declan M. McLoughlin
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Neurosciences
Eoin O'Neill, Rosa Chiara Goisis, Ruth Haverty, Andrew Harkin
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Behavioral Sciences
J. David, S. Gormley, A. L. McIntosh, V. Kebede, G. Thuery, A. Varidaki, E. T. Coffey, A. Harkin
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Obstetrics & Gynecology
Cathy Monteith, Karen Flood, Ragamallika Pinnamaneni, Terri A. Levine, Fiona A. Alderdice, Julia Unterscheider, Fionnuala M. McAuliffe, Patrick Dicker, Elizabeth C. Tully, Fergal D. Malone, Adrienne Foran
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Pharmacology & Pharmacy
Eoin O'Neill, Justin D. Yssel, Caoimhe McNamara, Andrew Harkin
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Neurosciences
Maria Velasco-Estevez, Sara O. Rolle, Myrthe Mampay, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Maria Velasco-Estevez, Kamal K. E. Gadalla, Nuria Linan-Barba, Stuart Cobb, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Sibylle Bechet, Sinead A. O'Sullivan, Justin Yssel, Steven G. Fagan, Kumlesh K. Dev
JOURNAL OF NEUROSCIENCE
(2020)
Article
Clinical Neurology
Terri A. Levine, Alison Davie-Gray, Hyun Min Kim, Samantha J. Lee, Lianne J. Woodward
Summary: This study examined the developmental outcomes of children born to opioid-dependent females enrolled in methadone maintenance and found that opioid-exposed children had lower motor, cognitive, and language scores, along with poor self-regulation, emotional regulation, eating/feeding regulation, and sensory processing compared to unexposed children. These differences in child outcomes were partly explained by maternal education, other substance use during pregnancy, and postnatal parental and family factors.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Neurosciences
Kate O'Reilly, Katherine O'Farrell, Oivind Midttun, Yuliia Rakovets, Jennifer David -Bercholz, Andrew Harkin
Summary: This study demonstrates that brain glia produce neuroactive metabolites via tryptophan-kynurenine catabolism and play a role in reactive glial associated neurodegeneration. Results suggest that inhibiting the kynurenine pathway (KP) metabolites can protect against neuronal atrophy associated with reactive glia.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Clinical Neurology
Karen M. Ryan, Martha Finnegan, Andrew Harkin, Declan M. McLoughlin
Summary: The study found no significant association between telomerase activity and depression, the therapeutic response to ECT, or exposure to adversity.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Rebecca Maher, Almudena Moreno-Borrallo, Dhruvi Jindal, Binh T. Mai, Eduardo Ruiz-Hernandez, Andrew Harkin
Summary: Nanomedicine focuses on developing nanocarriers to improve drug delivery to the brain for the treatment of neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers have advantages in delivering drugs to the central nervous system (CNS) due to their safety, drug loading capacity, and controlled release properties. These carriers have shown potential in penetrating the blood-brain barrier (BBB) and have been extensively studied in glioblastoma, epilepsy, and neurodegenerative disease models. Intranasal administration has emerged as an attractive route to bypass the BBB using tailored nanocarriers. This review explores the characteristics of polymeric and lipid-based nanocarriers and their potential for CNS drug repurposing, as well as the progress in intranasal drug delivery for neurological diseases.
Article
Biochemistry & Molecular Biology
Kapil Sharma, Kumlesh K. Dev
Summary: The role of altered myelin in the onset and development of schizophrenia and changes in myelin due to antipsychotics remains unclear. However, this study suggests that antipsychotics directly regulate glial cell dysfunction and exert a protective effect on myelin loss. These findings may have implications for the potential use of antipsychotics in Krabbe disease.
Article
Clinical Neurology
Marianna Mekhaeil, Melissa Jane Conroy, Kumlesh Kumar Dev
Summary: Metachromatic leukodystrophy (MLD) is a severe genetic leukodystrophy characterized by deficits in the arylsulfatase A gene (ARSA) and accumulation of sulfatide. In an ex vivo cerebellar slice culture model, sulfatide was found to induce demyelination through PARP-1 activation, oligodendrocyte loss, inflammation, and gliosis. Treatment with the PARP-1 inhibitor Olaparib attenuated sulfatide-induced effects, indicating its potential therapeutic utility in rare demyelinating diseases.