Review
Cell Biology
Angelica Varesi, Adelaide Carrara, Vitor Gomes Pires, Valentina Floris, Elisa Pierella, Gabriele Savioli, Sakshi Prasad, Ciro Esposito, Giovanni Ricevuti, Salvatore Chirumbolo, Alessia Pascale
Summary: This narrative review discusses the potential of proteins, lipids, metabolites, oxidative-stress-related molecules, and cytokines as biomarkers for Alzheimer's Disease (AD). It also explores the emerging role of miRNAs, lncRNAs, vitamins, and gut-microbiome-related molecules as diagnostic tools, providing new insights into the diagnosis and progression of this devastating disease.
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Article
Pharmacology & Pharmacy
Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Sebastiano Alfio Torrisi, Nicolo Musso, Federica Geraci, Maria Rosaria Tropea, Anna Privitera, Fabio Tascedda, Daniela Puzzo, Salvatore Salomone, Filippo Drago, Gian Marco Leggio, Filippo Caraci
Summary: The study shows that depression is a risk factor for Alzheimer's disease. Antidepressants can reverse memory deficits and depressive-like phenotype induced by Aβ oligomers, as well as prevent Aβ-induced oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Mohamed A. Hashem, Sahar S. Abd El Hamied, Eman M. A. Ahmed, Shimaa A. Amer, Aziza M. Hassan
Summary: The study evaluated the efficacy of vitamin C and vitamin E in mitigating oxidative stress, hematobiochemical, and histopathological changes in the kidney induced by copper sulfate (CuSO4) toxicity in broiler chickens. The findings showed the possible preventive and alleviating impacts of dietary antioxidants on hematobiochemical alterations, oxidative stress, and kidney damage induced by CuSO4 toxicity.
Review
Geriatrics & Gerontology
Maryam Hamid, Sumaiya Mansoor, Sanila Amber, Saadia Zahid
Summary: This meta-analysis and systematic review found that AD patients have significantly lower plasma levels of vitamin C, suggesting that vitamin C deficiency is involved in disease progression and supplementation may be an effective strategy for preventing and treating AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Boris Rabkin, Oren Tirosh, Joseph Kanner
Summary: The stomach acts as a bioreactor and plays a crucial role in biochemical reactions that impact human health. The oxidation of meat lipids in the stomach generates malondialdehyde (MDA), which is then absorbed into the bloodstream and modifies low-density lipoprotein (LDL) to MDA-LDL. The study found that vitamin E exhibits strong antioxidant activity against meat lipid oxidation in the stomach, especially at pH 3.0. The antioxidant activity of vitamin E at pH 3.0 is 20 times higher than that of catechin. Additionally, when combined with metmyoglobin (MbFe(+3)), vitamin E acts synergistically as a peroxidase/antioxidant couple, surpassing the antioxidant effect achieved by MbFe(+3)/catechin 150-fold. The continuous addition of low concentrations of vitamin E, catechin, and vitamin C helps maintain the meat's antioxidant activity, preventing lipid oxidation, reactive aldehyde generation, and loss of vitamin E.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Toxicology
Rajitha Gadde, Swati Betharia
Summary: This study demonstrated that NBMI effectively attenuated cell death and reduction of GSH levels induced by lead acetate in U-87 MG cells, with a superior neuroprotective effect compared to DMSA. NBMI also reduced Pb-induced neuroinflammation and enhanced cellular ability to efflux heavy metals.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Physiology
Aldona Baltusnikiene, Inga Staneviciene, Eugene Jansen
Summary: This article reviews the effects of high-dose vitamin E supplementation on vitamin E status and renal function in human and rodent studies. It discusses the adverse effects of high doses of vitamin E, specifically on the kidney. Recent studies in mice have shown elevated biomarkers of tissue toxicity and inflammation with higher doses of vitamin E, highlighting the need to reassess toxicity limits. The controversy surrounding the effects of vitamin E on the kidney is due to dose-response relationships that lack clarity in both human and animal studies.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuhua Zhu, Ziyan Wang, Shuxuan Yu, Chong Zhao, Baofeng Xu, Rui Liu, Li Xu, Yi Guo
Summary: This study investigated the neuroprotective effects of ginseng fibrous root against oxidative stress in Alzheimer's disease (AD). The results showed that ginseng fibrous root enzymatic hydrolysate exhibited antioxidant activities, protected cells from oxidative damage, and improved the survival rate of Caenorhabditis elegans under oxidative stress.
Review
Chemistry, Applied
Zhiyuan Zhang, Shuai Wang, Haining Tan, Pei Yang, Yuanyuan Li, Lingchuan Xu, Baoguo Duan, Yuhong Liu
Summary: This paper reviews recent research on the regulation of natural polysaccharides in Alzheimer's disease (AD) and systematically lists possible intervention pathways of polysaccharides targeting different mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arif Andra, Shoko Tanigawa, Tomohiro Bito, Atsushi Ishihara, Fumio Watanabe, Yukinori Yabuta
Summary: The study showed that B-12 deficiency accelerates Aβ-related paralysis in C. elegans models, while AsA-2G can rescue this paralysis phenotype. However, AsA-2G has no effect on the aggregation of Aβ peptides.
Article
Biochemistry & Molecular Biology
Pol Picon-Pages, Hugo Fanlo-Ucar, Victor Herrera-Fernandez, Sira Auselle-Bosch, Lorena Galera-Lopez, Daniela A. Gutierrez, Andres Ozaita, Alejandra R. Alvarez, Baldomero Oliva, Francisco J. Munoz
Summary: Alzheimer's disease (AD) is characterized by the presence of extracellular amyloid plaques in the brain, which are composed of aggregated amyloid beta-peptide (Aβ). It has been found that Aβ oligomers (oAβ) induce the production of reactive oxygen species (ROS), resulting in the oxidation of CaMKII alpha. This oxidized form of CaMKII alpha is present in brain samples from AD patients and is activated independently of calcium/calmodulin binding. The oxidation of CaMKII alpha promotes the phosphorylation of CREB and its translocation to the nucleus, leading to the transcription of ARC and BDNF in AD transgenic mice and primary cultures of murine hippocampal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Daniele La Russa, Domenico Montesano, Daniela Pellegrino, Marialaura Frisina, Giacinto Bagetta, Francesca Fallarino, Diana Amantea
Summary: Sunflower oil, with its high antioxidant potential, has shown promising effects in reducing brain infarct volume and edema, as well as preventing brain lipid peroxidation caused by cerebral ischemic injury in mice. It also helps maintain serum biological antioxidant potential, which is crucial for the prevention and treatment of cerebral ischemia.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Surgery
Cecile Chague, Thomas Gautier, Ludivine Dal Zuffo, Jean-Paul Pais de Barros, Audrey Wetzel, Georges Tarris, Gaetan Pallot, Laurent Martin, Severine Valmary-Degano, Valerie Deckert, Laurent Lagrost, Etienne Daguindau, Philippe Saas
Summary: This study found that HDL deficiency leads to LPS accumulation and exacerbates aGVHD. However, administration of HDL isolated from human plasma significantly decreases the mortality and severity of aGVHD. HDL infusion also plays an important role in mitigating liver aGVHD by reducing immune infiltration and inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Behavioral Sciences
Parthena Martin, Tangui Maurice, Arnold Gammaitoni, Gail Farfel, Brooks Boyd, Bradley Galer
Summary: Fenfluramine is an effective anti-seizure medication for patients with Dravet syndrome. It acts as a serotonin releaser and positive modulator of the sigma-1 receptor. The study showed that Fenfluramine enhances the low-dose effects of neuro(active) steroids and involves the 5-HT1A and 5-HT2A receptors in memory function.
EPILEPSY & BEHAVIOR
(2022)
Article
Chemistry, Medicinal
Francesca S. Abatematteo, Philip D. Mosier, Mauro Niso, Leonardo Brunetti, Francesco Berardi, Fulvio Loiodice, Marialessandra Contino, Benjamin Delprat, Tangui Maurice, Antonio Laghezza, Carmen Abate
Summary: The sigma-1 receptor is important in physiological and pathological processes, and the phenoxyalkylpiperidine compounds show potential as high-affinity agonists. Compound 1a, in particular, exhibits strong activity and warrants further investigation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Matthias Scheiner, Alexandra Sink, Matthias Hoffmann, Cassandre Vrigneau, Erik Endres, Allison Carles, Christoph Sotriffer, Tangui Maurice, Michael Decker
Summary: Selective and pseudoirreversible photoswitchable BChE inhibitors were synthesized to investigate their biological functions and the mechanisms by which they affect Alzheimer's disease. One of the compounds showed significant differences in activity both in vitro and in vivo, and exhibited complete recovery in a murine cognition-deficit AD model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Cell Biology
Lucie Crouzier, Alberto Danese, Yuko Yasui, Elodie M. Richard, Jean-Charles Lievens, Simone Patergnani, Simon Couly, Camille Diez, Morgane Denus, Nicolas Cubedo, Mireille Rossel, Marc Thiry, Tsung-Ping Su, Paolo Pinton, Tangui Maurice, Benjamin Delprat
Summary: This study found that activating the S1R receptor can counteract the functional abnormalities of MAMs in Wolfram syndrome. The S1R agonist restores calcium ion transfer and mitochondria! respiration, corrects increased autophagy and mitophagy, and alleviates behavioral symptoms.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino, Tsung-Ping Su
Summary: Autophagy is a crucial cellular process with implications in various diseases. In this study, researchers discovered that the molecular chaperone SIGMAR1 is involved in the transport of TFEB into the nucleus by chaperoning the NP protein POM121, which is responsible for recruiting KPNB1. The disruption of this process in ALS-FTD patients with the C9orf72 subtype leads to impaired autophagy. However, overexpression of SIGMAR1 or POM121, as well as treatment with pridopidine, a SIGMAR1 agonist, can rescue these deficits, suggesting their potential therapeutic use.
Article
Chemistry, Multidisciplinary
Julian Hofmann, Philipp Spatz, Rasmus Walther, Marcus Gutmann, Tangui Maurice, Michael Decker
Summary: Flavonoids have potential as disease-modifying agents against neurodegenerative disorders, including Alzheimer's disease. Hybridization of taxifolin and silibinin with cinnamic acid showed synergistic effects in phenotypic screening assays. By replacing the flavonoid part and improving the chemical bond, the activity of the compounds was enhanced. Taxifolin and quercetin derivatives were the most active compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Lucie Crouzier, Elodie M. Richard, Camille Diez, Hala Alzaeem, Morgane Denus, Nicolas Cubedo, Thomas Delaunay, Emily Glendenning, Sarah Baxendale, Jean-Charles Lievens, Tanya T. Whitfield, Tangui Maurice, Benjamin Delprat
Summary: Researchers report on the phenotypical characterization of two loss-of-function zebrafish mutant lines, highlighting the critical role of wfs1a and wfs1b in cellular function and potential therapeutic approaches for WS.
HUMAN MOLECULAR GENETICS
(2022)
Review
Pharmacology & Pharmacy
Thomas Gautier, Valerie Deckert, Maxime Nguyen, Catherine Desrumaux, David Masson, Laurent Lagrost
Summary: Phospholipid Transfer Protein (PLTP) plays a significant role in lipid transfer between lipoproteins and cells in the bloodstream. It affects the transport of triglycerides and cholesterol in the blood and plays a crucial role in immune response and inflammation regulation.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Allison Carles, Audrey Schlernitzauer, Michel Vignes, Gerard Cros, Richard Magous, Tangui Maurice, Catherine Oiry
Summary: This study aims to analyze the consequences of mice's exposure to different concentrations of C4F7N gas at different time points. The results show that exposure to C4F7N gas can lead to memory impairments and brain toxicity, particularly in female mice.
Article
Biochemistry & Molecular Biology
Christelle Lasbleiz, Amandine Peyrel, Pauline Tarot, Jerome Sarniguet, Lucie Crouzier, Nicolas Cubedo, Benjamin Delprat, Mireille Rossel, Tangui Maurice, Jean-Charles Lievens
Summary: This study demonstrates that PRE-084 can prevent mutant TDP43 toxicity by enhancing the ER stress response and antioxidant cascade through the NRF2 signaling pathway.
Article
Medicine, Research & Experimental
Lucie Crouzier, Elodie M. Richard, Camille Diez, Morgane Denus, Amandine Peyrel, Hala Alzaeem, Nicolas Cubedo, Thomas Delaunay, Tangui Maurice, Benjamin Delprat
Summary: Wolfram syndrome (WS) is a rare neurodegenerative disease with no current treatment options. The mutated gene WFS1 encodes a protein called Wolframin, which plays a role in regulating calcium transfer and mitochondrial activity. Using a zebrafish model of WS, researchers found that overexpression of the NCS1 protein can restore mitochondrial dysfunction and excessive locomotion, suggesting a potential therapeutic strategy for WS.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Carmen Abate, Tangui Maurice
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Philipp Spatz, Thomas Zimmermann, Sophie Steinmueller, Julian Hofmann, Tangui Maurice, Michael Decker
Summary: This study designed a series of benzimidazole-carbamate compounds that selectively inhibit BChE based on docking studies, showing potential for the treatment of AD.
RSC MEDICINAL CHEMISTRY
(2022)