Article
Psychiatry
Laura Orsolini, Silvia Bellagamba, Virginio Salvi, Umberto Volpe
Summary: This article describes a 20-year-old patient with clozapine-resistant schizophrenia and comorbid cannabinoid use disorder, who was successfully treated with a combination of clozapine and brexpiprazole, and later switched to clozapine with long-acting injectable aripiprazole.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Elias Wagner, Dan Siskind, Peter Falkai, Oliver Howes, Christoph Correll, Jimmy Lee, William G. Honer, John M. Kane, Emilio Fernandez-Egea, Thomas R. E. Barnes, Alkomiet Hasan
Summary: This study conducted an online Delphi survey to develop consensus recommendations for the optimization of clozapine monotherapy. The recommendations include specific treatment options for certain symptoms and management of side effects. The study results provide guidance for clinical decision-making and future research in treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
Elias D. Mouchlianitis, Lucy D. Vanes, Derek K. Tracy, Anne-Katherin Fett, Daniel Joyce, Sukhi S. Shergill
Summary: Glutamatergic dysfunction is associated with treatment resistance in individuals with schizophrenia. This study used neurochemical and functional brain imaging methods to investigate glutamatergic dysfunction and reward processing in treatment-resistant and treatment-responsive schizophrenia. The results suggest that glutamatergic differences can differentiate treatment-resistant and treatment-responsive schizophrenia, which has potential diagnostic value.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu, Ze-Zhi Li
Summary: This study aimed to investigate the efficacy of amisulpride augmentation therapy in treating patients with treatment-resistant schizophrenia. The results showed that amisulpride augmentation therapy improved psychiatric symptoms and cognitive function with tolerability and safety.
MILITARY MEDICAL RESEARCH
(2022)
Article
Psychiatry
Shushan Zheng, Sherry Kit Wa Chan, Jimmy Lee
Summary: This study surveyed psychiatrists in Hong Kong and Singapore to understand their familiarity and prescribing practices in treatment-resistant schizophrenia and clozapine-resistant schizophrenia. The results showed that, despite the familiarity with treatment guidelines, delays in prescribing clozapine still occur. The study also found regional differences in alternative treatment methods to clozapine.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Chuanjun Zhuo, Yong Xu, Haibo Wang, Chunhua Zhou, Jian Liu, Xiaocui Yu, Hailin Shao, Hongjun Tian, Tao Fang, Qianchen Li, Jiayue Chen, Shuli Xu, Xiaoyan Ma, Weiliang Yang, Cong Yao, Bo Li, Anqu Yang, Yuhui Chen, Guoyong Huang, Chongguang Lin
Summary: Clozapine-induced metformin-resistant prediabetes/diabetes is common in the early-treatment resistance subtype of treatment-resistant schizophrenia and is associated with poor clinical efficacy of clozapine.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Jerome Brunelin, Filipe Galvao, Marine Mondino
Summary: This retrospective study investigated the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant auditory verbal hallucinations. The results showed that low frequency rTMS could significantly decrease these symptoms.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Psychiatry
Amina Aissa, Rahma Jouini, Uta Ouali, Yosra Zgueb, Fethi Nacef, Zouhaier El Hechmi
Summary: The study aims to investigate demographic, clinical, and biochemical patient characteristics as potential predictors of response to clozapine in patients with Treatment Resistant Schizophrenia (TRS). Results showed that patients with better premorbid social functioning in childhood and early adolescence tend to have a better response to clozapine. Additionally, a shorter delay in clozapine initiation, having tried at least one atypical antipsychotic, and having schizophrenia paranoid subtype were significantly predictive of a good response to clozapine.
COMPREHENSIVE PSYCHIATRY
(2022)
Article
Psychiatry
Leeba Rezaie, Azadeh Nazari, Roya Safari-Faramani, Shamarina Shohaimi, Habibolah Khazaie
Summary: This study investigated the knowledge and attitude of Iranian psychiatrists towards the use of clozapine. Most respondents acknowledged prescribing clozapine and believed it to be more effective than other antipsychotic drugs. However, concerns about the safety of clozapine were common. Psychiatrists with longer work experience and academic positions were more optimistic towards clozapine use.
Article
Psychiatry
Julia M. Lappin, Kimberley Davies, Maryanne O'Donnell, Ishan C. Walpola
Summary: This study aimed to understand the use of clozapine and electroconvulsive therapy (ECT) in individuals with treatment-resistant psychosis. The study found that the utilization of these treatments was low and clozapine trials were often terminated prematurely without adequate testing. The study suggests strategies should be implemented to optimize the use of clozapine therapy and ECT in clinical settings to improve the therapeutic effectiveness for treatment-resistant psychosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Kohei Kitagawa, Shusuke Uekusa, Kazuhiro Matsuo, Kei Moriyama, Tatsuro Yamamoto, Yuji Yada, Masafumi Kodama, Yoshiki Kishi, Takashi Yoshio
Summary: This study aimed to evaluate the risk factors for clozapine-induced central nervous system abnormalities in patients with schizophrenia. Results showed that concomitant lithium usage and shorter illness durations were associated with an increased risk of CNS abnormalities. Clinicians are advised to closely monitor patients for CNS abnormalities, especially those with shorter illness durations, when using lithium in combination with clozapine.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Isabella R. Willcocks, Sophie E. Legge, Mariana Nalmpanti, Lucy Mazzeo, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T. R. Walters, Antonio F. Pardinas
Summary: Research suggests that increasing clozapine concentration may lead to decreased neutrophil counts in patients, but this association is weakened after considering the metabolic ratio between clozapine and its metabolite norclozapine. Genetic factors, specifically pharmacogenomic SNPs, could also play a role in influencing neutrophil counts during clozapine treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Rowena Jones, Isabel Morales-Munoz, Adrian Shields, Graham Blackman, Sophie E. Legge, Megan Pritchard, Daisy Kornblum, James H. MacCabe, Rachel Upthegrove
Summary: This study aims to investigate the neutrophil changes in response to clozapine and explore any association between neutrophil trajectory and treatment response. A retrospective cohort study identified 425 patients undergoing clozapine treatment, and the results showed that the trajectory of neutrophil count changes in the first month and baseline neutrophil count were associated with treatment response at 2 years.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Genetics & Heredity
Jiangbo Ying, Qian Hui Chew, Roger S. McIntyre, Kang Sim
Summary: Treatment-resistant schizophrenia (TRS) is difficult to treat and has a negative impact on patients' quality of life. Clozapine is effective for TRS but has side effects. This review summarizes the current genetic factors associated with TRS, clozapine resistance, and side effects. Further research is needed to identify risk genes and understand the interactions between genes and relevant clinical factors in TRS treatment.
Letter
Psychiatry
Ping-Tao Tseng, Mu-Hong Chen, Chih-Sung Liang
Summary: The article highlights the importance of preventing clozapine resistance as an effective treatment strategy for CRS, and emphasizes the significance of optimizing clozapine treatment. Distinguishing between treatment-resistant schizophrenia and CRS is crucial for developing treatment strategies for these challenging populations.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Varsha D. Badal, Colin A. Depp, Philip D. Harvey, Robert A. Ackerman, Raeanne C. Moore, Amy E. Pinkham
Summary: Inaccurate self-assessment is common among people with serious mental illness and it negatively affects their functional outcomes. This study used network modeling to explore the temporal relationships between confidence, accuracy judgments, and feedback. The results suggest that individuals with schizophrenia and bipolar disorder have stronger connections between confidence and accuracy judgments, but weaker associations between feedback and subsequent judgments compared to healthy controls.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Cameron D. Harvey, Raeanne C. Moore, Colin A. Depp, Robert A. Ackerman, Amy E. Pinkham, Philip D. Harvey
Summary: This study examines the relationship between sadness and the quality of activities in individuals with bipolar illness using ecological momentary assessment. The results suggest that momentary sadness is correlated with the quality of concurrent activities, and both sadness and the quality of everyday activities predict observer ratings of everyday functioning.
COGNITIVE NEUROPSYCHIATRY
(2022)
Article
Psychiatry
Nina Dalkner, Raeanne C. Moore, Colin A. Depp, Robert A. Ackerman, Amy E. Pinkhame, Philip D. Harvey
Summary: Mood states have been found to be correlated with self-assessment accuracy in various functional domains and psychiatric conditions. This study used ecological momentary assessment to examine the association between longitudinally assessed moods and immediate self-assessment accuracy of cognitive performance in individuals with schizophrenia and bipolar disorder. The results showed that negative moods were significantly associated with impairments in self-assessment accuracy and cognitive performance in individuals with bipolar disorder, but not in those with schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Lisa R. Steenkamp, Emma M. Parrish, Samantha A. Chalker, Varsha D. Badal, Amy E. Pinkham, Philip D. Harvey, Colin A. Depp
Summary: This study examined the impact of childhood trauma on day-to-day social experiences among individuals with psychotic disorders or affective disorders. The results showed that higher levels of childhood trauma were associated with increased perceived threat, negative self-perception, reduced social motivation, desire for social avoidance, and lower sense of belongingness during recent social interactions. These negative social perceptions were primarily linked with emotional abuse and neglect. It was also found that paranoia was more strongly associated with negative social perceptions among individuals with high levels of trauma. However, childhood trauma was not associated with the frequency or type of social interactions.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser
Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.
Article
Psychiatry
Emma M. Parrish, Philip D. Harvey, Robert A. Ackerman, Amy E. Pinkham, Colin A. Depp, Jason Holden, Eric Granholm
Summary: This study aims to understand the relationship between positive affect (PA) and negative affect (NA) among people with schizophrenia, and explore the impact of social context on mood variability. The results show that some patients with schizophrenia do not experience negative affect, some experience both positive and negative affect, and some show a more normative affect pattern.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
L. Okruszek, M. Jarkiewicz, A. Piejka, M. Chrustowicz, M. Krawczyk, A. Schudy, P. D. Harvey, D. L. Penn, K. Ludwig, M. F. Green, A. E. Pinkham
Summary: This study investigated the relationship between loneliness and neuro- and social cognitive mechanisms in patients with schizophrenia. The results showed that patients reported higher levels of loneliness compared to healthy controls, and loneliness was positively correlated with negative and affective symptoms in patients. It was also found that loneliness was negatively associated with mentalizing and emotion recognition abilities in patients with social-cognitive impairments, but not in those who performed at normative levels.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychiatry
Rohit Voleti, Stephanie M. Woolridge, Julie M. Liss, Melissa Milanovic, Gabriela Stegmann, Shira Hahn, Philip D. Harvey, Thomas L. Patterson, Christopher R. Bowie, Visar Berisha
Summary: Automated language analysis is a useful tool in clinical research involving individuals with mental health disorders. This study focuses on using linguistic output to assess functional outcomes and predicts clinical variables related to mental health status and competency. The results show that language features are valuable for predicting these variables.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Dylan J. Jester, Michael L. Thomas, Emily T. Sturm, Philip D. Harvey, Matcheri Keshavan, Beshaun J. Davis, Shekhar Saxena, Rajesh Tampi, Heather Leutwyler, Michael T. Compton, Barton W. Palmer, Dilip Jeste
Summary: Social determinants of health (SDoHs) have a significant impact on the health of individuals with schizophrenia-spectrum psychotic disorders (SSPDs), with risk factors including childhood abuse, parental psychopathology, parental communication problems, bullying, and low socioeconomic status in urban areas. Racial/ethnic discrimination and social fragmentation are also associated with the prevalence and symptoms of psychosis. Homeless populations and seriously mentally ill individuals are more likely to experience food insecurity. Further research is needed to understand the positive factors and develop interventions to reduce the adverse health impacts of SDoHs.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Sara E. Jones, Philip D. Harvey
Summary: Cognitive impairment is strongly related to disability and educational attainment, and previous drug development efforts have focused on transmitter systems associated with specific conditions. However, recent genomics studies suggest common influences on cognition across populations and conditions. Stimulation of muscarinic cholinergic receptors (M1 and M4) shows potential for enhancing cognition and treating psychotic symptoms, especially with recent developments improving tolerability. The M1 and M4 receptor stimulation may serve as a trans-diagnostic treatment model.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Arundati Nagendra, Chih-Wei Joshua Liu, Kim T. Mueser, Philip D. Harvey, Colin A. Depp, Raeanne C. Moore, Beshaun Davis, Amy E. Pinkham
Summary: This study examined the ethno-racial differences in daily functioning among individuals with serious mental illnesses, specifically focusing on non-Latinx White, non-Latinx Black, and Latinx participants. The findings indicate that Black participants engaged more in solitary or passive leisure activities compared to White and Latinx participants, and reported less vocational activity and home-based active leisure. While some of these differences were explained by socioeconomic status and symptom severity, further research is needed to explore sociocultural and racism-related factors. Clinical implications and suggestions for future research are discussed.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychiatry
Varsha D. Badal, Colin A. Depp, Amy E. Pinkham, Philip D. Harvey
Summary: This study aimed to investigate the metacognitive construct of Introspective Accuracy (IA) by exploring the alignment between self-generated accuracy judgments, confidence, and objective information regarding performance. The results showed a sustained disconnect between self-assessments and actual performance, and the cognitive origins of IA are still unclear. The time-series analysis revealed that confidence levels were affected to a different extent in participants with schizophrenia and bipolar disorder in specific tasks.
SCHIZOPHRENIA RESEARCH-COGNITION
(2023)
Article
Psychiatry
Angelo Sadeghpoura, David L. Poggec, Elizabeth M. O'Donoghue, Tim Bigdelif, Alex O. Rothbaum, Philip D. Harvey
Summary: Half of individuals have experienced a trauma sufficient to meet the criteria for PTSD, and the relationship between intelligence and trauma is unclear. A study was conducted on child and adolescent inpatients, assessing their intelligence, academic achievement, and trauma experiences. The results showed that those who experienced physical and sexual abuse performed poorly in intellectual domains, and exposure to substance abuse was associated with lower intelligence and higher CTQ scores.
PSYCHIATRY RESEARCH
(2023)
Meeting Abstract
Neurosciences
Courtney Dowell-Esquivel, Peter Kallestrup, Sara Czaja, Colin A. Depp, John Saber, Philip D. Harvey
BIOLOGICAL PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Raeanne C. Moore, Robert A. Ackerman, Madisen T. Russell, Laura M. Campbell, Colin A. Depp, Philip D. Harvey, Amy E. Pinkham
Summary: This study examined the feasibility and potential of self-administered ecological momentary cognitive testing among older adults with mild cognitive impairment (MCI) and cognitively normal controls. The results showed that the adherence to the mobile cognitive tests was high and did not differ by MCI status. Moreover, the tests demonstrated good reliability and validity, and there were significant group differences between participants with MCI and cognitively normal controls. These findings suggest that ecological momentary cognitive testing can be useful for clinical trials and measuring cognitive changes over time in individuals at risk for Alzheimer's disease.
FRONTIERS IN DIGITAL HEALTH
(2022)