Article
Neurosciences
Elias Paolo Casula, Gaetano Tieri, Lorenzo Rocchi, Rachele Pezzetta, Michele Maiella, Enea Francesco Pavone, Salvatore Maria Aglioti, Giacomo Koch
Summary: Immersive virtual reality can lead to a strong feeling of embodiment over artificial body parts, but the neural mechanisms behind this phenomenon are not yet fully understood. By tracking real-time brain dynamics, researchers found that observing virtual body parts is associated with a rapid decrease in cortical activity in the hand region of the primary motor cortex, as well as rapid changes in activity within a fronto-parietal circuit. These findings suggest that changes in bodily representations are supported by dynamic interactions within a highly plastic network.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Monica Betta, Giacomo Handjaras, Andrea Leo, Alessandra Federici, Valentina Farinelli, Emiliano Ricciardi, Francesca Siclari, Stefano Meletti, Daniela Ballotta, Francesca Benuzzi, Giulio Bernardi
Summary: EEG slow waves play a crucial role in regulating essential processes such as learning and sensory disconnection. They may involve complex interactions within and between cortical and subcortical structures. Moreover, simultaneous EEG-fMRI recordings show that slow waves are associated with specific hemodynamic changes in different brain regions.
Review
Neurosciences
Alexandra Gaillard, Daniel J. Fehring, Susan L. Rossell
Summary: Over the past decade, there has been a significant increase in the number of studies investigating sex differences in executive functions, with evidence suggesting males and females engage different strategies depending on task demands. However, due to methodological variability and the complexity of neural networks involved, a simple overarching statement regarding gender differences during executive control cannot be provided. Sex differences in neural mechanisms are present in the majority of tasks assessed, emphasizing the importance of considering gender in future research.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Kareen Heinze, Jennifer Cumming, Amrita Dosanjh, Sophia Palin, Shannen Poulton, Andrew P. Bagshaw, Matthew R. Broome
Summary: The study aimed to investigate the potential neurobiological mechanisms linking longer-term physical activity interventions to mental health and cognitive outcomes in children, adolescents, and young adults. Results showed that most studies reported improvements in mental health and cognition outcomes following longer-term physical activity interventions, which were associated with neurobiological alterations. Future research should consider measures of pre-existing fitness levels and target individuals who would benefit the most from such interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Clementine Garric, Yannick Wamain, Jean-Francois Rouland, Quentin Lenoble
Summary: This study investigated neurophysiological dynamics during a visuocognitive task in glaucoma patients and healthy controls. The results showed a delay in early visual processing in glaucoma patients and potential compensation during higher-level cognitive processing. The study also found differences in accuracy performance and decision criterion between the two groups in behavioral data.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Mari Tervaniemi
Summary: This paper introduces the development of MMN stimulation paradigms, starting from the paradigms used in basic science and then moving to paradigms that are relevant for studies on music learning and musical expertise. The author wishes to stimulate further development of paradigms through historical and thematic perspectives.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Matthew Defenderfer, Pinar Demirayak, Kristina M. Visscher
Summary: The visual cortex is a heavily studied region in neuroscience due to its well-defined retinotopic organization. Researchers have developed a method to transform retinal objects into their expected representations on the cortical surface without a functional scan. By calculating the product of the retinal object with the cortical vertex's pRF, the expected response of a given vertex to the retinal object can be determined.
Review
Neurosciences
Matthias Staib, Sascha Fruhholz
Summary: The study found that the temporal voice area (TVA) shows similar neural responses to textural sound patterns (TSPs) as to natural voice and non-voice sounds, partially explaining activation patterns typically observed during voice processing. This suggests that the human voice area does not only process higher-order voice information, but also evaluates the perceptual and acoustic quality of non-voice sounds, responding to them with a voice-like processing pattern when detecting some rudimentary perceptual similarity with voices.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Cell Biology
Julien Claron, Matthieu Provansal, Quentin Salardaine, Pierre Tissier, Alexandre Dizeux, Thomas Deffieux, Serge Picaud, Mickael Tanter, Fabrice Arcizet, Pierre Pouget
Summary: To better understand the brain's role in primate behavior, simultaneous recording of neural activity at different spatiotemporal scales is necessary but challenging. This study uses functional ultrasound imaging and single-unit activity (SUA) recordings in macaque monkeys to show that SUA can estimate neurovascular response below the typical fMRI spatial resolution. The study also finds that SUA and cerebral blood volume (CBV) activities are not correlated during resting state but are correlated during tasks, suggesting implications for interpreting functional imaging findings.
Article
Neurosciences
Maryana Daood, Leehe Peled-Avron, Rachel Ben-Hayun, Michael Nevat, Judith Aharon-Peretz, Rachel Tomer, Roee Admon
Summary: This study found that acute administration of methylphenidate (MPH) can reduce choice impulsivity and increase activation in the striatum and connectivity between the striatum and prefrontal cortex in healthy individuals. The magnitude of the change in fronto-striatal connectivity induced by MPH may account for individual differences in the impact of MPH on impulsive behavior.
Article
Multidisciplinary Sciences
Moe Okayasu, Tensei Inukai, Daiki Tanaka, Kaho Tsumura, Reiko Shintaki, Masaki Takeda, Kiyoshi Nakahara, Koji Jimura
Summary: The Stroop effect is a well-known phenomenon where language and color information interfere with each other. In this study, researchers found that the interference occurs during perception of color-word stimuli and involves a functional connection between the lateral prefrontal cortex and cerebellum. Furthermore, the prefrontal cortex amplifies cerebellar activity while the cerebellum suppresses prefrontal activity, suggesting the involvement of a fronto-cerebellar loop in goal-directed behavior during perceptual conflicts.
NATURE COMMUNICATIONS
(2023)
Article
Humanities, Multidisciplinary
Alberto Ara, Jeison Parra-Tijaro, Josep Marco-Pallares
Summary: Music processing and its hedonic value is influenced by brain activations in perceptual, cognitive, and affective areas. Theta rhythms have been proposed as a means of synchronization between network nodes involved in music valuation. This study used fMRI and EEG to investigate the relationship between these rhythmic synchronizations and music-evoked pleasantness, and found that the synchronization was modulated by the degree of pleasantness experienced.
PSYCHOLOGY OF AESTHETICS CREATIVITY AND THE ARTS
(2022)
Article
Behavioral Sciences
Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini
Summary: Laboratory animal research has provided valuable knowledge about the function of cortical circuits at the laminar level, which, when combined with fMRI and neural models, offers new opportunities for insights. Recent human studies have demonstrated the importance of high-resolution fMRI in studying laminar-specific activity in the human brain. Advancements in laminar fMRI are opening up new possibilities for studying questions in basic cognitive neuroscience.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Benjamin O. Barnett, Jeffrey A. Brooks, Jonathan B. Freeman
Summary: Previous research has shown that social-conceptual associations, such as stereotypes, can influence the visual representation of faces. This influence requires feedback signals from the medial orbitofrontal cortex (mOFC) during perception. Backward masking disrupts this feedback and reduces functional connectivity between VTC regions. Masking can abolish the impact of stereotypical associations on face representation in the FG.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Pedro A. Valdes-Sosa, Lidice Galan-Garcia, Jorge Bosch-Bayard, Maria L. Bringas-Vega, Eduardo Aubert-Vazquez, Iris Rodriguez-Gil, Samir Das, Cecile Madjar, Trinidad Virues-Alba, Zia Mohades, Leigh C. MacIntyre, Christine Rogers, Shawn Brown, Lourdes Valdes-Urrutia, Alan C. Evans, Mitchell J. Valdes-Sosa
Summary: The CHBMP repository is an open multimodal neuroimaging and cognitive dataset from 282 healthy participants in Cuba, including EEG, MRI, psychological tests, and demographic information. This dataset is hosted by Synapse.org and available for access.
Article
Neurosciences
Jennifer D. Whitesell, Adam Liska, Ludovico Coletta, Karla E. Hirokawa, Phillip Bohn, Ali Williford, Peter A. Groblewski, Nile Graddis, Leonard Kuan, Joseph E. Knox, Anh Ho, Wayne Wakeman, Philip R. Nicovich, Thuc Nghi Nguyen, Cindy T. J. van Velthoven, Emma Garren, Olivia Fong, Maitham Naeemi, Alex M. Henry, Nick Dee, Kimberly A. Smith, Boaz Levi, David Feng, Lydia Ng, Bosiljka Tasic, Hongkui Zeng, Stefan Mihalas, Alessandro Gozzi, Julie A. Harris
Summary: Research using mice models demonstrated the differences in projection patterns between layer 2/3 and layer 5 neurons within the DMN, further revealing the anatomical correlates of the DMN at different spatial scales.
Article
Neurosciences
Caterina Montani, Carola Canella, Adam J. Schwarz, Jennifer Li, Gary Gilmour, Alberto Galbusera, Keith Wafford, Daniel Gutierrez-Barragan, Andrew McCarthy, David Shaw, Karen Knitowski, David McKinzie, Alessandro Gozzi, Christian Felder
Summary: The cholinergic drug xanomeline, acting at M1/M4 muscarinic receptors, induces widespread functional activity changes in the rodent brain, including decreased connectivity in the neocortex and striatum, and increased functional connectivity within the nucleus accumbens. Moreover, its effects on phencyclidine and ketamine suggest a modulatory role in specific functional networks within the brain.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo-yong Park, Seok-Jun Hong, Sofie L. Valk, Casey Paquola, Oualid Benkarim, Richard A. I. Bethlehem, Adriana Di Martino, Michael P. Milham, Alessandro Gozzi, B. T. Thomas Yeo, Jonathan Smallwood, Boris C. Bernhardt
Summary: The study suggests that there are significant differences in structural connectome organization in individuals with autism compared to typically developing controls, particularly in low-level somatosensory regions and high-level association cortices. Computational models reveal that macroscale anomalies are related to atypical increases in recurrent excitation/inhibition and subcortical inputs into cortical microcircuits in sensory and motor areas.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Richard Tagne Simo, Erika Myriam Baiguerel, Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Mohamadou Ahmadou, Charlette Nangue, Phelix Bruno Telefo
Summary: The study reveals a widespread awareness of breast cancer in the North Region of Cameroon, but there are still misconceptions and lack of information, leading to insufficient understanding of the importance of screening and early diagnosis among certain groups.
INTERNATIONAL JOURNAL OF BREAST CANCER
(2021)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Alessandra Georgette Ciancone Chama, Evgenia Shlosman, Lorenzo Mattioni, Alberto Galbusera, Giuliano Iurilli, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Abnormal tactile response is a common feature in Autism Spectrum Disorders (ASDs), and patients with Phelan-McDermid syndrome (PMS) also exhibit similar tactile response abnormalities. This study investigated the neural substrates involved in whisker-guided behaviors in Shank3b(-/-) mice, which showed deficits in texture discrimination and low responsiveness to repetitive whisker stimulation. Reduced activation in the primary somatosensory cortex (S1) and hippocampus was observed, suggesting impaired sensory processing. Resting-state fMRI further revealed decreased connectivity between S1 and the hippocampus, potentially impairing whisker-dependent cues recognition.
Article
Biochemistry & Molecular Biology
Daniel Gutierrez-Barragan, Neha Atulkumar Singh, Filomena Grazia Alvino, Ludovico Coletta, Federico Rocchi, Elizabeth De Guzman, Alberto Galbusera, Mauro Uboldi, Stefano Panzeri, Alessandro Gozzi
Summary: This study used resting-state fMRI to investigate the spontaneous brain activity in awake mice and found that it exhibits specific functional network topography and dynamic structure. These findings are important for understanding the conscious states in higher mammalian species.
Article
Integrative & Complementary Medicine
Paul F. Seke Etet, Muaawia A. Hamza, Ahmed El-Tahir, Lorella Vecchio, Sayed Y. Osman, Gwiria M. H. Satti, Mohamed H. A. Ismail, Mohammed Farahna, Alfred K. Njamnshi, Abdu Adem
Summary: This study found that subfraction F5 of Garcinia kola extract prevented the development of motor signs and improved the disease profile in a mouse model of diabetic encephalopathy induced by STZ. The antidiabetic activity of beta-lactam molecules accounted for at least some of these effects.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Federico Rocchi, Carola Canella, Shahryar Noei, Daniel Gutierrez-Barragan, Ludovico Coletta, Alberto Galbusera, Alexia Stuefer, Stefano Vassanelli, Massimo Pasqualetti, Giuliano Iurilli, Stefano Panzeri, Alessandro Gozzi
Summary: This study investigates how inactivation of a cortical node affects brain-wide fMRI connectivity in mice, providing causal evidence that cortical inactivation can unexpectedly increase fMRI connectivity.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Francesca Viscido, Alessandra Georgette Ciancone Chama, Alberto Galbusera, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Sensory abnormalities are common in individuals with autism spectrum disorders (ASDs). A study found that mice lacking the ASD-associated gene Cntnap2 display altered somatosensory processing and deficits related to core symptoms of ASDs. The study suggests that these mice can serve as a reliable model to study sensory abnormalities in ASDs.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Psychiatry
Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D'Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Summary: The study suggests that D-aspartate plays an important role in neurodevelopment and functioning, and the dysmetabolism of D-aspartate is associated with neurodevelopmental disorders such as schizophrenia. Using a mouse model, the researchers found that early occurrence of D-aspartate can influence neurodevelopment and lead to social recognition memory deficits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Paleontology
Mauro Rubini, Alessandro Gozzi, Nunzia Libianchi, Elena Dellu, Ferdinando Spano, Claudio Di Biasi, Matteo Pendenza, Paola Sala, Floriana Filannino, Paola Zaio
Summary: This study aimed to differential diagnose cranial lesions on a medieval skeleton and explored the significance of comorbidity. The findings suggest that the case represents a rare occurrence of metastatic neuroblastoma. The exploration of comorbidity, such as the presence of metastatic carcinoma and edentulism, has the potential to expand our knowledge about cancer in the past.
INTERNATIONAL JOURNAL OF PALEOPATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patricia Nora Awad, Valerio Zerbi, Erin M. M. Johnson-Venkatesh, Francesca Damiani, Marco Pagani, Marija Markicevic, Sarah Nickles, Alessandro Gozzi, Hisashi Umemori, Michela Fagiolini
Summary: The study found that there are connectivity and functional alterations in the brain of CDKL5 Deficiency Disorder (CDD) patients, which are related to cognitive deficits. The results further demonstrate the important role of CDKL5 in neuronal connectivity and cognitive function.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Urte Neniskyte, Ugne Kuliesiute, Auguste Vadisiute, Kristina Jevdokimenko, Ludovico Coletta, Senthilkumar Deivasigamani, Daina Pamedytyte, Neringa Daugelaviciene, Daiva Dabkeviciene, Emerald Perlas, Aditya Bali, Bernadette Basilico, Alessandro Gozzi, Davide Ragozzino, Cornelius T. Gross
Summary: The mature mammalian brain connectome develops through the extension and pruning of neuronal connections. Glial cells, particularly phospholipid scramblase Xkr8, play a crucial role in the elimination of unnecessary neuronal synapses and projections. This study highlights the importance of phospholipid scrambling by Xkr8 in the pruning of developing neuronal projections, with implications for brain development and hyperconnectivity.
Correction
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement M. Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. B. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Groehn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Nene Ahidjo, Leonard Ngarka, Paul F. Seke Etet, Wepnyu Y. Njamnshi, Leonard N. Nfor, Michel K. Mengnjo, Jonas G. Basseguin Atchou, Edmond N. Mouofo, Godwin Y. Tatah, Faustin Dong A. Zok, Bonaventure T. Ngadjui, Wilfred Ngwa, Alfred K. Njamnshi
Summary: This study assessed the effects of Garcinia kola on cognitive and motor changes in a murine model of acute radiation syndrome. Treatment with Garcinia kola significantly mitigated the development of cognitive and motor decline induced by radiation exposure.
BRAIN COMMUNICATIONS
(2021)