期刊
NEUROPSYCHOPHARMACOLOGY
卷 36, 期 4, 页码 744-752出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2010.207
关键词
neuropeptide; memory; consolidation; inhibitory avoidance; object recognition; mice
资金
- University of California, Irvine, CA
- National Institute of Mental Health [MH-71313
- RKR]
- Mitsubishi Pharma Research Foundation
- National Institute on Drug Abuse (DMD)
- Canadian Institutes of Health Research (SDC)
- Deutsche Forschungsgemeinschaft [SFB-TRR58, TP A03
- HCP]
- Max-Planck Society
- Humboldt Foundation [2007
- HCP]
Neuropeptide S (NPS) has been shown to promote arousal and anxiolytic-like effects, as well as facilitation of fear extinction. In rodents, NPS receptors (NPSR) are prominently expressed in brain structures involved in learning and memory. Here, we investigate whether exogenous or endogenous NPS signaling can modulate acquisition, consolidation, or recall of emotional, spatial, and contextual memory traces, using two common behavioral paradigms, inhibitory avoidance (IA) and novel object recognition. In the IA paradigm, immediate and delayed post-training central NPS administration dose dependently enhanced memory retention in mice, indicating that NPS may act during the consolidation phase to enhance long-term memory. In contrast, pre-training or pre-test NPS injections were ineffective, suggesting that NPS had no effect on IA memory acquisition or recall. Peripheral administration of a synthetic NPSR antagonist attenuated NPS-induced IA memory enhancement, showing pharmacological specificity. NPS also enhanced hippocampal-dependent non-aversive memory in the novel object recognition task. In contrast, NPSR knockout mice displayed deficits in IA memory, novel object recognition, and novel place or context recognition, suggesting that activity of the endogenous NPS system is required for memory formation. Blockade of adrenergic signaling by propranolol attenuated NPS-induced memory enhancement in the IA task, indicating involvement of central noradrenergic systems. These results provide evidence for a facilitatory role of NPS in long-term memory, independent of memory content, possibly by acting as a salience signal or as an arousal-promoting factor. Neuropsychopharmacology (2011) 36, 744-752; doi:10.1038/npp.2010.207; published online 8 December 2010
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