Review
Neurosciences
Melinda Hersey, Amanda K. Bacon, Lydia G. Bailey, Mark A. Coggiano, Amy H. Newman, Lorenzo Leggio, Gianluigi Tanda
Summary: The rapid increase in individuals affected by psychostimulant use disorder (PSUD) has highlighted the potential of Modafinil (MOD) as a therapeutic option due to its non-addictive properties, despite its similar mechanism of action to commonly abused psychostimulants on the dopamine transporter (DAT). Clinical and preclinical studies have demonstrated the efficacy of MOD in treating symptoms related to PSUD and other psychiatric disorders involving alterations of brain dopamine systems.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
David E. Moorman, Gary Aston-Jones
Summary: The prefrontal cortex plays a critical role in the execution and inhibition of reward seeking. This study investigates the neural activity in different subregions of the medial prefrontal cortex (PL and IL) during various stages of cocaine seeking. The results reveal complex functions and contributions of both PL and IL regions to drug seeking and addiction.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
D. R. Rossato, H. Z. Rosa, J. L. O. Rosa, L. H. Milanesi, V. G. Metz, L. F. D'Avila, M. E. Burger
Summary: Tactile stimulation (TS) may have positive effects on addiction recovery by preventing or reducing amphetamine (AMPH) relapse behavior and inducing molecular neuroadaptations in the brain. Further research can include TS as a useful tool in the treatment of psychostimulant addiction, alongside conventional detoxification programs with pharmacotherapies and psychological treatments.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Roberto Ciccocioppo, Giordano de Guglielmo, Hongwu Li, Miriam Melis, Lucia Caffino, Quienwei Shen, Ana Domi, Fabio Fumagalli, Gregory A. Demopulos, George A. Gaitanaris
Summary: The research showed that inhibiting PDE7 enzyme can reduce self-administration of nicotine and prevent reinstatement of nicotine seeking behavior. In animal experiments, PDE7 inhibitors were found to enhance dopaminergic transmission, suggesting potential for treating nicotine addiction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ginna Uruena-Mendez, Andrea Dimiziani, Lidia Belles, Raphael Goutaudier, Nathalie Ginovart
Summary: Current research suggests that alterations in dopamine transmission in the striatum contribute to impulsivity and novelty-seeking, and may be related to a higher susceptibility to drug abuse. However, there is still debate about whether this susceptibility results from a hyperdopaminergic or hypodopaminergic state. In this study, rats with high impulsivity and novelty-seeking behaviors exhibited lower availability of D2/3 receptors and higher amphetamine-induced dopamine release in the striatum, which predicted higher levels of cocaine intake. Cocaine self-administration did not affect D2/3 receptor availability or impulsivity in these rats. Importantly, cocaine exposure led to a baseline-dependent decrease in stimulated dopamine release in high-impulsive/high novelty-seeking rats only, and to a baseline-dependent increase in novelty-seeking in low-impulsive/low novelty-seeking rats only. Overall, this study suggests that susceptibility to drug abuse is associated with an innate hyper-responsive dopamine system that promotes impulsive and novelty-seeking behaviors, and leads to stronger initial drug-reinforcing effects. However, with repeated cocaine use, tolerance to drug-induced dopamine elevations develops, resulting in compensatory increases in drug consumption to overcome reduced reward effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Monika Vrajova, Romana Slamberova, Cyril Hoschl, Saak Ovsepian
Summary: Methamphetamine is a powerful and highly addictive psychostimulant with detrimental effects on mental and physical health. It poses a significant challenge in terms of sleep impairments and addiction relapse, calling for targeted interventions. Understanding the mechanisms behind methamphetamine-related sleep disruption is crucial for translational and clinical psychiatry, highlighting the need for further research and therapeutic approaches.
Review
Pharmacology & Pharmacy
Saeideh Karimi-haghighi, Maedeh Mahmoudi, Fatemeh Sayehmiri, Roghayeh Mozafari, Abbas Haghparast
Summary: The mechanism behind relapse in addiction treatment with psychostimulant drugs is not fully understood, and there is conflicting evidence regarding the role of the endocannabinoid system in regulating relapse in preclinical studies. This systematic review evaluated the effect of endocannabinoid modulators on the reinstatement of commonly abused psychostimulants. Thirty-nine articles using different animal models were selected, and the results suggest that cannabinoid receptor antagonists and agonists may have potential in inhibiting the reinstatement of cocaine and methamphetamine addiction, but the effectiveness depends on time, dose, and route of administration.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kathrine Louise Jensen, Soren Brogger Jensen, Kenneth Lindegaard Madsen
Summary: Psychostimulant use disorder is a major global health issue with no effective pharmacological treatments available. This review provides an overview of pharmacological treatments targeting different aspects of psychostimulant addiction, including the dopamine system, the glutamate system, and the severe side effects of quitting long-term use. Promising results have been found with drugs modulating the dopamine system, cognitive enhancers, and drugs targeting the glutamate system, but further research is needed for sufficient evidence of efficacy and tolerability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study focused on the time-dependent neurochemical changes induced by amphetamine which revealed region and dose-dependent alterations in gene expression. Individual differences in neurotransmission and gene expression in brain pathways may influence behavioral sensitization to amphetamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Psychiatry
M. Carmen Blanco-Gandia, Sandra Montagud-Romero, Marta Rodriguez-Arias
Summary: Various factors influence an individual's vulnerability to drug addiction, including hedonic eating activating reward circuits and the global increase in obesity rates affecting children and young people. The comorbidity between eating disorders and drug addiction has been a focus of recent research. Integrated responses are needed for patients with substance use and binge eating disorders.
WORLD JOURNAL OF PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Francesco Dernie, Harrison S. France, Elizabeth T. Thomas, Maja Bilip, Nicholas J. DeVito, Robin E. Ferner, Anthony R. Cox, Carl Heneghan, Jeffrey K. Aronson, Georgia C. Richards
Summary: Opioid deaths have increased in England and Wales. Coroners' reports provide important insights to prevent future deaths, but opioid-related reports have not been synthesized. This study aimed to identify opioid-related reports and explore coroners' concerns.
JOURNAL OF PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Patrycja Kleczkowska, Dorota Sulejczak, Malgorzata Zaremba
Summary: Disulfiram is a well-known anti-alcohol agent that also shows potential in treating other forms of drug addiction, but it carries the greatest risk of pharmacological interactions compared to other drugs used in alcohol dependence.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panayotis K. Thanos, Madison McCarthy, Daniela Senior, Samantha Watts, Carly Connor, Nikki Hammond, Kenneth Blum, Michael Hadjiargyrou, David Komatsu, Heinz Steiner
Summary: This study found that chronic co-administration of methylphenidate (MP) and fluoxetine (FLX) can significantly reduce depressive and anxiety-like behaviors, as well as increase overall activity levels. These results provide important insights into the potential neurobiological and neurochemical effects of simultaneously using these two drugs.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leisheng Shi, Yan Wang, Chong Li, Kunlin Zhang, Quansheng Du, Mei Zhao
Summary: AddictGene is a resource that integrates multidimensional data related to commonly abused substances, including gene expression, gene-gene interaction, gene-drug interaction, and epigenetic regulatory information. This database provides detailed information about differentially expressed genes, offering a valuable resource for studying the molecular mechanisms underlying addiction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Psychiatry
Nilofar Vafaie, Hedy Kober
Summary: The study indicates that drug cue and craving indicators play significant roles in drug use and relapse outcomes, supporting the incorporation of craving assessment across treatment stages, especially in the early stages of care.
Article
Biochemistry & Molecular Biology
Wai Chong Wong, Michela Marinelli
Article
Neurosciences
Leora Yetnikoff, Anita Y. Cheng, Heather N. Lavezzi, Kenneth P. Parsley, Daniel S. Zahm
JOURNAL OF COMPARATIVE NEUROLOGY
(2015)
Article
Anatomy & Morphology
Rhett A. Reichard, Suriya Subramanian, Mikiyas T. Desta, Tej Sura, Mary L. Becker, Comeron W. Ghobadi, Kenneth P. Parsley, Daniel S. Zahm
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Obstetrics & Gynecology
Kanani E. Titchen, Dyani Loo, Elizabeth Berdan, Mary Becker Rysavy, Jessica J. Ng, Iman Sharif
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2017)
Article
Neurosciences
Emily R. Hankosky, Sara R. Westbrook, Rachel M. Haake, Michela Marinelli, Joshua M. Gulley
PSYCHOPHARMACOLOGY
(2018)
Article
Anatomy & Morphology
Suriya Subramanian, Rhett A. Reichard, Hunter S. Stevenson, Zachary M. Schwartz, Kenneth P. Parsley, Daniel S. Zahm
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Heather N. Lavezzi, Kenneth P. Parsley, Daniel S. Zahm
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Anatomy & Morphology
Rhett A. Reichard, Kenneth P. Parsley, Suriya Subramanian, Hunter S. Stevenson, Zachary M. Schwartz, Tej Sura, Daniel S. Zahm
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Anatomy & Morphology
Rhett A. Reichard, Kenneth P. Parsley, Suriya Subramanian, Daniel S. Zahm
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
Adam G. Gordon-Fennell, Ryan G. Will, Vorani Ramachandra, Lydia Gordon-Fennell, Juan M. Dominguez, Daniel S. Zahm, Michela Marinelli
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Pediatrics
Marlyse F. Haward, John Lantos, Annie Janvier
Article
Obstetrics & Gynecology
Haley A. Steffen, Samantha R. Swartz, J. Brooks Jackson, Kimberly A. Kenne, Patrick P. Ten Eyck, Abbey S. Merryman, Claire N. Castaneda, Katharine Marsden, Timothy Maxwell, Anna E. Merrill, Matthew D. Krasowski, Mary B. Rysavy
Summary: The study aimed to estimate the prevalence of SARS-CoV-2 among pregnant patients at a rural Midwest tertiary care hospital and examine the association between infection and demographics, clinical factors, and maternal and neonatal outcomes. The results showed higher rates of SARS-CoV-2 infection during pregnancy among racial and ethnic minorities and patients without private insurance. It was found that infected patients and their neonates did not have an increased risk of adverse outcomes.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Editorial Material
Neurosciences
Matthew B. Pomrenze, Michela Marinelli
BIOLOGICAL PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Claire Castaneda, Katharine Marsden, Timothy Maxwell, Patrick Ten Eyck, Daren Kuwaye, Kimberly A. Kenne, Abbey S. Merryman, Haley A. Steffen, Samantha R. Swartz, Anna E. Merrill, Matthew D. Krasowski, J. Brooks Jackson, Mary B. Rysavy
Summary: Maternal obesity is linked to adverse outcomes for mothers and their offspring, including complications during pregnancy and increased risk of COVID-19. A study found that obese women face greater challenges during delivery, such as hypertension and macrosomia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)