Review
Health Care Sciences & Services
Daniela Senior, Rania Ahmed, Eliz Arnavut, Alexandra Carvalho, Wen Xuan Lee, Kenneth Blum, David E. Komatsu, Michael Hadjiargyrou, Rajendra D. Badgaiyan, Panayotis K. Thanos
Summary: The majority of animal studies on methylphenidate (MP) use methods such as intraperitoneal injections, subcutaneous injections, or the oral gavage route. However, the most clinically relevant route is oral administration. Intraperitoneal injections provide an immediate and maximum dose, but only represent a limited window of the drug's effects. Subcutaneous injections do not accurately reflect oral exposure, and the oral-gavage method has adverse effects and may be stressful for animals. The use of a two-bottle drinking method allows for free consumption of MP and more accurately mirrors human treatment, enabling the study of MP's effects on development, behavior, neurochemistry, and brain function.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychiatry
Thamyris Santos-Silva, Dogukan Hazar Ulgen, Caio Fabio Baeta Lopes, Francisco S. Guimaraes, Luciane Carla Alberici, Carmen Sandi, Felipe V. Gomes
Summary: Adolescent individuals show significant diversity in cortical dynamics and behavioral outcomes. The developing adolescent brain is sensitive to social experiences and environmental insults, which can influence the emergence of personality traits. Mitochondria play a crucial role in brain maturation and the development of mental illnesses, with specific mitochondrial features in certain brain regions accounting for behavioral differences in adulthood. This study investigates whether distinct adolescent behavioral phenotypes and the consequences of early adolescent stress exposure are associated with changes in PFC mitochondria-related genes and respiratory chain capacity.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Behavioral Sciences
Kateryna Murlanova, Michael Kirby, Lev Libergod, Mikhail Pletnikov, Albert Pinhasov
Summary: Social interactions are crucial for many species, and understanding the neural mechanisms underlying social rank behavior is important. This review discusses the use of rodent models to study social hierarchies and the development of reliable behavioral tests.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Nathan A. Fox, George A. Buzzell, Santiago Morales, Emilio A. Valadez, McLennon Wilson, Heather A. Henderson
Summary: This review examines the differential developmental trajectories among children with behavioral inhibition (BI), discussing specific attention processes related to social anxiety risk as well as the processes of automatic control and planful control. The findings suggest that automatic control processes increase the risk of social anxiety, while planful control processes decrease anxiety risk.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Social
Ruyun Wu, Jiyi Huang, Jiefeng Ying, Qianqian Gao, Jiaqi Guo, Jianing You
Summary: The study found that behavioral inhibition, fun seeking, and drive were positively associated with nonsuicidal self-injury, while reward responsiveness was negatively associated. Difficulty in emotion regulation and depression played mediating roles in these associations, providing a more comprehensive understanding of risk factors for self-injury.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Multidisciplinary Sciences
Will Kenkel
Summary: The development of automated behavior scoring technology has greatly benefited the study of social behavior. However, relying too heavily on computer analysis risks missing important nuances and creating a disconnect between researchers and their subject. It is recommended to focus on automating the collection of behavioral data instead, using continuous automated observations to minimize confounding factors. Leveraging machine vision and machine learning can help increase the efficiency of behavioral observation and collection.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Psychology, Developmental
H. Hill Goldsmith, Emily C. Hilton, Jenny M. Phan, Katherine L. Sarkisian, Ian C. Carroll, Kathryn Lemery-Chalfant, Elizabeth M. Planalp
Summary: An enduring issue in the study of mental health is understanding how childhood characteristics progress to maladaptive forms. This study examines the role of behavioral inhibition (BI) on social anxiety (SA) in adolescence. The results show bidirectional paths between BI and SA, with both genetic and environmental influences influencing childhood BI and adolescent SA. Parenting stress emerges as a significant interaction with BI in predicting SA, highlighting the importance of environmental factors.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoguang Liu, Kaluvu Balaraman, Ciaran C. Lynch, Michaeline Hebron, Priya Ketankumar Shah, Shicheng Hu, Max Stevenson, Christian Wolf, Charbel Moussa
Summary: The study found that Ubiquitin-Specific Protease-13 (USP13) plays a critical role in the neuropathology of alpha-synuclein and inhibiting USP13 can reduce alpha-synuclein levels and improve motor and behavioral symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Jaouad Bouayed, Torsten Bohn
Summary: The interaction between humans and SARS-CoV-2 can lead to various outcomes, including changes in human behavior that may facilitate the virus transmission. Some individuals infected with COVID-19 have displayed odd and irresponsible behaviors, potentially aiding in the spread of the virus.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luisa Teixeira-Santos, Eduardo Verissimo, Sandra Martins, Teresa Sousa, Antonio Albino-Teixeira, Dora Pinho
Summary: NADPH oxidase isoform-2 (NOX2) has been implicated in the pathophysiology of neuropathic pain (NP), and the study aimed to evaluate the effects of NOX2-selective inhibitor on behavioral responses and neuroinflammation in male and female mice. The results showed that NOX2i reduced SNI-induced mechanical hypersensitivity and microglial activation in both sexes, with some behavioral effects in females.
Article
Psychology, Multidisciplinary
Nuray Cancer, Yagmur Sezer Efe, Oznur Basdas
Summary: Adolescents spend about 3 hours a day on social media, primarily engaging in visual communication. Exposure to appearance ideals on social media may lead to appearance-based anxiety and binge-eating behavior in adolescents. This study found that girls, those who perceive low family income, and those influenced by social media have higher social appearance anxiety.
CURRENT PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda
Summary: The study showed that long-term treatment with yohimbine can be an effective therapeutic option to prevent the progression of chronic kidney disease, by reducing renal dysfunction, lowering blood pressure, and suppressing renal fibrosis.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Biology
Mark J. Butler, Donald C. Behringer
Summary: Social distancing is not unique to humans, as it also exists in wild animals, where it is influenced by animal movement and sociality, as well as other factors. Studying behavioral immunity in wild animals is important for controlling disease spread in nature.
Article
Public, Environmental & Occupational Health
Maria Cucciniello, Paolo Pin, Blanka Imre, Gregory A. Porumbescu, Alessia Melegaro
Summary: This study examines how public health communication strategies can be improved by appealing to other-regarding preferences. The results suggest that pro-vaccine messages that invoke past experiences of dependence and vulnerability, stress cooperation as a social norm, and emphasize the presence of vulnerable individuals can increase vaccination intentions.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Neurosciences
Jia-Wei Hao, Wen-Long Qiao, Qing Li, Shuang Wei, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: In this study, it was found that the α2A-AR agonist DEX has an analgesic effect by activating peripheral α2A-AR and suppressing P2X3 receptor activity. This effect is mediated through intracellular G(i/o) proteins and cAMP signaling pathways in neurons.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Anne Marije Kaag, Anna E. Goudriaan, Taco J. De Vries, Tommy Pattij, Reinout W. Wiers
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Anne Marije Kaag, Reinout W. Wiers, Taco J. de Vries, Tommy Pattij, Anna E. Goudriaan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Danai Riga, Leanne J. M. Schmitz, Yvar van Mourik, Witte J. G. Hoogendijk, Taco J. De Vries, August B. Smit, Sabine Spijker
Article
Neurosciences
Roeland F. Struik, Nathan J. Marchant, Roel de Haan, Huub Terra, Yvar van Mourik, Dustin Schetters, Madison R. Carr, Marcel van der Roest, Tim S. Heistek, Taco J. De Vries
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Behavioral Sciences
Roeland F. Struik, Taco J. De Vries, Jamie Peters
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Jasper A. Heinsbroek, Taco J. De Vries, Jamie Peters
Summary: This review discusses the mechanisms by which glutamate, dopamine, and opioid signaling interact to mediate the primary rewarding effects of opioids, and covers the glutamatergic systems and circuits that mediate the expression, extinction, and reinstatement of opioid seeking over the course of opioid addiction.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Esther Visser, Mariana R. Matos, Rolinka J. van der Loo, Nathan J. Marchant, Taco J. de Vries, August B. Smit, Michel C. van den Oever
Article
Substance Abuse
Tommy Pattij, Yvar van Mourik, Leontien Diergaarde, Taco J. de Vries
DRUG AND ALCOHOL DEPENDENCE
(2020)
Correction
Medicine, Research & Experimental
Jasper A. Heinsbroek, Taco J. De Vries, Jamie Peters
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2020)
Review
Behavioral Sciences
Maria Nalberczak Skora, Tommy Pattij, Anna Beroun, Georgios Kogias, Dirk Mielenz, Taco de Vries, Kasia Radwanska, Christian P. Mueller
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Review
Nutrition & Dietetics
Janette de Goede, Kerstin G. van der Mark-Reeuwijk, Kees P. Braun, Saskia le Cessie, Sarah Durston, Rutger C. M. E. Engels, Anna E. Goudriaan, Karel G. M. Moons, Wilma A. M. Vollebergh, Taco J. de Vries, Reinout W. Wiers, Jaap Oosterlaan
Summary: Alcohol consumption in young people may negatively affect brain function and development, including abnormal gray matter development and increased risk of alcohol use disorder. Current evidence on white matter, brain activity, cognitive function, and educational achievement remains limited or unclear.
ADVANCES IN NUTRITION
(2021)
Article
Neuroimaging
Antonia Kaiser, Liesbeth Reneman, Paul J. Lucassen, Taco J. de Vries, Anouk Schrantee, Anne Marije Kaag
Summary: The study examined the neural mechanisms underlying the interaction between working memory (WM) and emotional reactivity (ER) in adult ADHD participants, finding that taxing WM reduced reactivity to emotional stimuli in heavy drinkers but did not affect neural correlates of ER in ADHD participants. No impairments in WM or ER were found in the ADHD group, possibly due to the relatively unimpaired ADHD population and well-matched control group. Further investigation is needed to determine if targeting WM may be effective in participants with severe ER impairments in ADHD.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Biology
Hussein Ghareh, Isis Alonso-Lozares, Dustin Schetters, Rae J. Herman, Tim S. Heistek, Yvar Van Mourik, Philip Jean-Richard-dit-Bressel, Gerald Zernig, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant
Summary: This study shows the critical role of environmental contexts in promoting nicotine relapse and the importance of aIC activity in context-induced relapse.
Correction
Biochemistry & Molecular Biology
Lisa Genzel, Roger Adan, Anton Berns, Jeroen J. J. P. van den Beucken, Arjan Blokland, Erik H. W. G. M. Boddeke, Willy M. Bogers, Ronald Bontrop, R. Bulthuis, Teun Bousema, Hans Clevers, Tineke C. J. J. Coenen, Anne-Marie van Dam, Peter M. T. Deen, K. W. van Dijk, Bart J. L. Eggen, Ype Elgersma, Izel Erdogan, Bernhard Englitz, J. Martje Fentener van Vlissingen, Susanne la Fleur, Ron Fouchier, Carlos P. Fitzsimons, Wilbert Frieling, Bart Haagmans, Balthasar A. Heesters, Marloes J. A. G. Henckens, Sander Herfst, Elly Hol, Daniel van den Hove, Marien I. de Jonge, Jos Jonkers, Leo A. B. Joosten, Andries Kalsbeek, Maarten Kamermans, Harm H. Kampinga, Martien J. Kas, Jaap Keijer, Sander Kersten, Amanda J. Kiliaan, Taco W. A. Kooij, Sander Kooijman, Werner J. H. Koopman, Aniko Korosi, Harm J. Krugers, Thijs Kuiken, Steven A. Kushner, Jan A. M. Langermans, Heidi M. B. Lesscher, Paul J. Lucassen, Esther Lutgens, Mihai G. Netea, Lucas P. J. J. Noldus, Jos W. M. van der Meer, Frank J. Meye, Joram D. Mul, Kees van Oers Jocelien D. A. Olivier, R. Jeroen Pasterkamp, Ingrid H. C. H. M. Philippens, Jos Prickaerts, B. J. A. Pollux, Patrick C. N. Rensen, Jacco van Rheenen, Ronald P. van Rij, Laila Ritsma, Barry. H. G. Rockx, Benno Roozendaal, Evert M. van Schothorst, K. Stittelaar, Norbert Stockhofe, Dick F. Swaab, Rik L. de Swart, Louk J. M. J. Vanderschuren, Taco J. de Vries, Femke de Vrij, Richard van Wezel, Corette J. Wierenga, Maximilian Wiesmann, Ingo Willuhn, Chris I. de Zeeuw, Judith R. Homberg
Article
Behavioral Sciences
Maria C. Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I. Mesman, Damiaan Denys, Taco J. De Vries, Tommy Pattij
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2017)