Review
Neurosciences
Roberta Celli, Francesco Fornai
Summary: The review focuses on the role of ionotropic glutamate receptors in seizures and the clinical development of iGlu receptor antagonists for drug-resistant epilepsy. Antagonists inhibit experimental seizures while agonists worsen them, but clinical development is limited by adverse effects. Perampanel is the only drug specifically targeting iGlu receptors marketed for focal epilepsy.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Neurosciences
Sebastiano A. Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggio
Summary: Several studies have shown that chronic stress has a negative effect on recognition memory, but the effects of acute stress on this cognitive ability have not been well studied. This study aimed to investigate the impact of acute stress on recognition memory consolidation in a sex-dependent manner. The results showed that acute stress did not affect memory performance in male and female mice immediately after training, but it altered memory performance after a 24-hour delay, with sex-dependent effects.
NEUROBIOLOGY OF STRESS
(2023)
Article
Medicine, Research & Experimental
Neda Valian, Marziyeh Sorayya, Sareh Asadi, Fatemeh Sherafati, Ali Ershad, Sara Savaheli, Abolhassan Ahmadiani
Summary: The study suggests that preconditioning with ultra-low dose of tramadol can reduce seizures induced by high dose tramadol, potentially through upregulation of Norbin and downregulation of NR1 and GluR1.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Behavioral Sciences
Fawaz Alasmari, Deen B. Sari, Hasan Alhaddad, Salim S. Al-Rejaie, Youssef Sari
Summary: This review explores the interactive role of acid-sensing ion channels (ASICs) and ionotropic glutamate receptors (iGluRs) in opioid dependence. The dysregulation of ASICs and iGluRs may play a crucial role in drug abuse and addiction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Lindsey N. Friend, Bridget Wu, Jeffrey G. Edwards
Summary: Cocaine influences VTA GABA cell glutamate plasticity and circuitry, with the plasticity being reversible and re-emerging after a 7-day abstinence. Chronic cocaine alters AMPA/NMDA ratios at glutamate synapses onto VTA GABA cells.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Review
Neurosciences
Angela M. Mabb
Summary: Transcription-translation coupling leads to the production of key proteins for controlling essential neuronal processes, while posttranslational signaling pathways, such as ubiquitination, also play a crucial role in regulating these processes. Ubiquitin attaches to its targets and plays a role in multiple signaling pathways, primarily by removing substrates via the proteasome. This review focuses on 40 years of progress on ubiquitination in the nervous system at glutamatergic synapses, highlighting its importance in various neuronal processes.
Review
Biochemistry & Molecular Biology
Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Wong
Summary: This article reviews how glutamate handling and glutamatergic function are affected by neuroinflammation and their contribution to cognitive impairment. The authors summarize the current data regarding glutamate in neurotransmission, including its receptors and regulation. They also examine the impact of inflammation on glutamate handling and neurotransmission, focusing on changes in glial cells and the effect of cytokines. Finally, they discuss the implications of these changes for perioperative neuroinflammation and perioperative neurocognitive disorders.
Review
Clinical Neurology
Anastasia Levinta, Shakila Meshkat, Roger S. McIntyre, Cameron Ho, Leanna M. W. Lui, Yena Lee, Rodrigo B. Mansur, Kayla M. Teopiz, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Felicia Ceban, Joshua D. Rosenblat
Summary: Ketamine has demonstrated antidepressant efficacy in patients with treatment-resistant depression, although its effectiveness may be affected by the level of treatment resistance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Anatomy & Morphology
S. Serter Kocoglu, C. Cakir, Z. Minbay, O. Eyigor
Summary: This study demonstrated the expression of glutamate receptor subunits in neuronostatin neurons, suggesting the formation of functional receptor complexes. These findings provide important clues for further research on the function and regulation mechanisms of neuronostatin neurons.
FOLIA MORPHOLOGICA
(2022)
Review
Psychiatry
Vikrant R. Mahajan, Sophie K. Elvig, Leandro F. Vendruscolo, George F. Koob, Valerie L. Darcey, M. Todd King, Henry R. Kranzler, Nora D. Volkow, Corinde E. Wiers
Summary: Alcohol use disorder is a chronic brain disorder characterized by compulsive alcohol seeking and disrupted brain function. Nutritional ketosis has shown potential in reducing alcohol withdrawal symptoms and craving by elevating ketone bodies in plasma and brain. This suggests that a ketogenic diet could be a unique treatment option for AUD, either alone or in combination with medications.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Ming Tatt Lee, Wei-Hao Peng, Hung-Wei Kan, Cheng-Chun Wu, Deng-Wu Wang, Yu-Cheng Ho
Summary: This article reviews the recent literature on the role of AMPA-glutamatergic neurotransmission in stress-induced maladaptive responses in emotional and mood-associated brain regions.
Article
Chemistry, Medicinal
Sandra Fernandez-Rodriguez, Claudia Esposito-Zapero, Teodoro Zornoza, Ana Polache, Luis Granero, Maria Jose Cano-Cebrian
Summary: The study explores the potential pharmacotherapy of NAC for alcohol use disorder and its effects on ethanol-induced activation. The results show that high doses of NAC stimulate cFOS expression in the NAcc, suppressed by MTEP; high doses of NAC may attenuate the ethanol-induced increase in cFOS expression in the NAcc.
Review
Biochemistry & Molecular Biology
Tzu-Hsin Huang, Ming-Chi Lai, Yu-Shiue Chen, Chin-Wei Huang
Summary: Status epilepticus (SE) is a neurological emergency with high mortality rate. The downregulation of GABAA receptors and upregulation of NMDA and AMPA receptors are the most widely accepted hypothesis underlying BZD resistance.
Review
Pharmacology & Pharmacy
Daniel C. Javitt
Summary: Cognitive impairment is a prominent feature of schizophrenia, and its assessment methods are well established. The role of social cognitive impairment and sensory-level dysfunction in functional outcomes has also been recognized. Treatment development targeting N-methyl-d-aspartate receptor (NMDAR) and its associated impairments has become encouraging. Mismatch negativity has emerged as a promising biomarker for early-stage drug development in schizophrenia.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)