Article
Biochemistry & Molecular Biology
Masuelli Sofia, Real Sebastian, Campoy Emanuel, Maria Teresita Branham, Diego Matias Marzese, Salomon Matthew, Gerardo De Blas, Arias Rodolfo, Levin Michael, Roque Maria
Summary: This study discovered differential DNA methylation and bioelectric differences between left-sided and right-sided breast tumors, which were associated with tumor proliferation. These findings provide new targets for future breast cancer therapeutic approaches.
MOLECULAR MEDICINE
(2022)
Article
Clinical Neurology
Wen Su, Kai Li, Chun-Mei Li, Xin-Xin Ma, Hong Zhao, Min Chen, Shu-Hua Li, Rui Wang, Bao-Hui Lou, Hai-Bo Chen, Chuan-Zhu Yan
Summary: The study found that Parkinson's disease patients with left onset had lower functional connectivity between the left orbitofrontal cortex and the left dorsal rostral putamen compared to those with right onset. Additionally, patients with left onset showed abnormal functional connectivity in the right hemisphere. The findings suggest that lateralization of motor symptoms is associated with distinct characteristics of cortico-striatal circuits in Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Leah T. Johnstone, Emma M. Karlsson, David P. Carey
Summary: Neuroscientific techniques show that left-handers have more unusual cerebral asymmetries for language compared to right-handers, with left-handers demonstrating less lateralization for language, faces, and bodies when they have typical cerebral asymmetries.
Article
Medicine, General & Internal
Asuman Orhan Varoglu, Adem Aydin
Summary: The study showed that Parkinson's disease patients with right-sided symptom onset had more severe neurological disability and higher motor function scores during follow-up, indicating a poorer prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Sha Zhu, Min Zhong, Yu Bai, Zhuang Wu, Ruxin Gu, Xu Jiang, Bo Shen, Jun Zhu, Yang Pan, Jingde Dong, Pingyi Xu, Jun Yan, Li Zhang
Summary: The study found that patients with left-dominant motor symptoms in Parkinson's Disease (PD) experienced more severe impairment in sleep quality compared to those with right-dominant symptoms. There was no significant difference in gait performance between left-dominant and right-dominant PD patients. However, PD patients with severe asymmetry in left-dominant symptoms showed shorter stride length and decreased range of motion of hip joints compared to those with severe asymmetry in right-dominant symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jianguo Wang, Sidi Ma, Peijie Yu, Xionglei He
Summary: The human brain exhibits anatomical symmetry, but also possesses fine-scale structural asymmetries that contribute to distinct functional divisions. Previous studies suggested that these asymmetric structures are primate specific or unique to humans, indicating recent evolution of genes responsible for human brain asymmetry. In our study, we identified over 1,500 traits associated with human brain asymmetry and discovered approximately 200 genes that are predominantly upregulated in brain tissues. Surprisingly, these genes are evolutionarily ancient and show brain-specific upregulation in humans, indicating the role of ancient genes in shaping the structural asymmetry of the human brain over time.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Behavioral Sciences
Philippe Voruz, Ioana Medeleine Constantin, Julie Anne Peron
Summary: The longitudinal trajectories of cognitive-neuropsychiatric symptoms in Parkinson's disease vary depending on the motor symptom asymmetry at disease onset. Further investigation is needed to explore the relationship with biomarkers.
Article
Multidisciplinary Sciences
Xin-Xin Fu, Ding-Hao Zhuo, Ying-Jie Zhang, Yun-Fei Li, Xiang Liu, Yan-Yi Xing, Ying Huang, Yi-Fan Wang, Tao Cheng, Dan Wang, Si-Han Chen, Yi-Jian Chen, Guan-Nan Jiang, Fu- Lu, Yu Feng, Xiao Huang, Jun Ma, Wei Liu, Ge Bai, Peng-Fei Xu
Summary: The emergence of left-right (LR) asymmetry in a patterning field along the anterior-posterior axis is still an unresolved problem in developmental biology. This study identifies Follistatin (Fst) as a regulator that restricts the propagation of Nodal ortholog Southpaw (Spaw) in the right lateral plate mesoderm (LPM) and facilitates the establishment of a robust LR asymmetric Nodal patterning. Furthermore, Fst inhibits the Activin-Nodal signaling pathway in the forebrain, contributing to the orderly propagation of asymmetric Nodal activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychology, Biological
Zhiqiang Sha, Dick Schijven, Amaia Carrion-Castillo, Marc Joliot, Bernard Mazoyer, Simon E. Fisher, Fabrice Crivello, Clyde Francks
Summary: Genes associated with brain asymmetry are linked to microtubule-related genes and embryonic brain expression, and have overlap with genetic variants related to autism, educational attainment, and schizophrenia. Left-right hemispheric asymmetry is crucial for healthy brain organization and language functions, but the mechanism behind establishing the human brain's left-right axis remains unidentified.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Developmental Biology
Brent H. Wyatt, Nirav M. Amin, Kristen Bagley, Dustin Wcisel, Michael K. Dush, Jeffrey A. Yoder, Nanette M. Nascone-Yoder
Summary: This study reveals the role of single-minded 2 gene in regulating left-right symmetry in the development of frog embryo stomach, further illustrating the importance of laterality factors in morphogenesis.
Article
Cell Biology
Eriko Kajikawa, Toru Miki, Masayoshi Takeda, Hiroshi Kiyonari, Hiroshi Hamada
Summary: The evolutionary diversity of brain left-right asymmetry was examined by studying reptile embryos. The Chinese softshell turtle and the red-eared slider turtle showed left-sided expression of certain genes in the developing forebrain, while this asymmetry was not detected in the Madagascar ground gecko. These findings suggest that brain left-right asymmetry varies even among reptiles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Teije C. Middelkoop, Julia Garcia-Baucells, Porfirio Quintero-Cadena, Lokesh G. Pimpale, Shahrzad Yazdi, Paul W. Sternberg, Peter Gross, Stephan W. Grill
Summary: This study demonstrates that the active torque generation dependent on CYK-1/Formin plays a crucial role in chiral symmetry breaking of actomyosin flows, driving left-right symmetry breaking in the nematode worm. The activity of Non-Muscle Myosin II, on the other hand, promotes cortical actomyosin flows but is not essential for chiral symmetry breaking.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Naiara Demnitz, Kathrine Skak Madsen, Line K. Johnsen, Michael Kjaer, Carl-Johan Boraxbekk, Hartwig R. Siebner
Summary: The study found that older adults show similar trends of asymmetry in the white matter microstructure of the corticospinal tract and dexterity as adolescents, but to a lesser degree. However, unlike adolescents, there was no evidence of a linear relationship between CST microstructure asymmetry and dexterity in older adults.
Article
Management
Laszlo Csato
Summary: This paper compares the performance of the eigenvalue method and the row geometric mean as two weighting procedures. Through numerical experiments, it is found that the priorities derived from the two eigenvectors in the eigenvalue method do not always agree, while the row geometric mean serves as a compromise between them.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2024)
Article
Multidisciplinary Sciences
Eric Chevrier, Elena Moro, Pierre Pelissier, Anna Castrioto, Paul Krack, Valerie Fraix, Bettina Debu
Summary: Balance disorders are common in Parkinson's disease (PD), and one-leg stance performance can predict fall risk. This study investigated one-leg stance strategies in PD patients and found that they tend to choose and perform better on the leg with less impairment. However, the most stable leg is not always chosen, and the side of the chosen leg may switch after seven years of disease duration. It is important to identify PD patients who choose the least stable leg as they may be at a higher risk of falls and may benefit from specific rehabilitation strategies.
Article
Audiology & Speech-Language Pathology
Annelies Aerts, Katja Batens, Patrick Santens, Pieter Van Mierlo, Eline Huysman, Robert Hartsuiker, Dimitri Hemelsoet, Wouter Duyck, Robrecht Raedt, Dirk Van Roost, Miet De Letter
Article
Audiology & Speech-Language Pathology
Annelies Aerts, Pieter van Mierlo, Robert J. Hartsuiker, Patrick Santens, Miet De Letter
BRAIN AND LANGUAGE
(2015)
Review
Clinical Neurology
Patrick Santens, Giel Vanschoenbeek, Marijke Miatton, Miet De Letter
ACTA NEUROLOGICA BELGICA
(2018)
Article
Clinical Neurology
Miet De Letter, John Van Borsel, Ellen Lanckmans, Katja Batens, Dimitri Hemelsoet, Wouter Duyck, Wim Fias, Patrick Santens
Article
Audiology & Speech-Language Pathology
M. De Letter, A. Bruggeman, K. De Keyser, P. Van Mierlo, H. Buysse, D. Van Roost, P. Santens
BRAIN AND LANGUAGE
(2020)
Article
Clinical Neurology
Elze R. Timmers, Marenka Smit, Anouk Kuiper, Anna L. Bartels, Sterre van der Veen, A. M. Madelein van der Stouwe, Patrick Santens, Bruno Bergmans, Marina A. J. Tijssen
PARKINSONISM & RELATED DISORDERS
(2019)
Review
Clinical Neurology
Micheline De Meyer, Lisa Vereecke, Peter Bottenberg, Wolfgang Jacquet, Anthony B. Sims, Patrick Santens
ACTA NEUROLOGICA BELGICA
(2020)
Review
Clinical Neurology
P. Santens, A. Bruggeman
Summary: The concept of functional movement disorders has evolved greatly over the past few decades, with changing views on their relationship with psychological stressors or personality disorders. This evolution has influenced diagnostic criteria, management approaches, and discussions regarding compensation after trauma, with a focus on ethical and legal considerations.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Clinical Neurology
Evelien De Groote, Annelies Bockstael, Dick Botteldooren, Patrick Santens, Miet De Letter
Summary: This study investigated auditory deviance detection in patients with Parkinson's disease through EEG measurements. Results showed no significant differences between PD patients and healthy controls for frequency, duration, and gap deviants, but a trend towards increased MMN amplitude and latency in response to intensity deviants in PD patients was observed. Increased intensity MMN amplitude may indicate a compensatory mechanism for auditory intensity processing and attention switching in PD.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Editorial Material
Clinical Neurology
Arnout Bruggeman, Lucas Levrau, Patrick Santens
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Letter
Clinical Neurology
Patrick Santens
ACTA NEUROLOGICA BELGICA
(2022)
Article
Neurosciences
Evelien De Groote, Ehsan Eqlimi, Annelies Bockstael, Dick Botteldooren, Patrick Santens, Miet De Letter
Summary: This study investigated the neural oscillatory mechanisms associated with speech-in-noise processing in Parkinson's disease (PD). Results showed significantly increased alpha power in PD patients during the speech-in-noise recognition task, along with significantly decreased speech recognition scores, indicating that PD patients allocate more cognitive resources to support speech-in-noise processing.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Patrick Santens, Arnout Bruggeman, Nika Schuermans, Hannah Verdin, Bart Dermaut
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Psychology, Biological
Yana Criel, Claire Boon, Emma Depuydt, Jara Stalpaert, Eline Huysman, Marijke Miatton, Patrick Santens, Pieter van Mierlo, Miet De Letter
Summary: The current study investigated the effects of aging and sex on phoneme discrimination and categorization using MMN and P300 ERPs. The results showed that elderly individuals had reduced MMN and P300 amplitudes compared to young individuals, but the scalp distribution was unaffected. The P300 latency was delayed in elderly individuals compared to young individuals, but no differences in MMN latency were observed. Sex had no significant effects on MMN and P300 measures.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Review
Clinical Neurology
Patrick Santens
ACTA NEUROLOGICA BELGICA
(2018)