Review
Oncology
Matthew A. Kirkman, Benjamin H. M. Hunn, Michael S. C. Thomas, Andrew K. Tolmie
Summary: People with brain tumors, including those previously treated, commonly experience neurocognitive impairments in executive function, memory, attention, and social/emotional functioning. Various factors influence cognitive outcomes in glioma patients, such as tumor characteristics, treatments administered, baseline cognition, anti-epileptic drugs, and genetics. Surgery initially has a negative effect on cognition but most cases recover over time. Radiotherapy has adverse effects on cognition, while the role of chemotherapy is unclear. The effects of age, gender, and fatigue on cognitive outcomes have conflicting evidence.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Yujiro Yamada, Emily M. Frith, Vickie Wong, Robert W. Spitz, Zachary W. Bell, Raksha N. Chatakondi, Takashi Abe, Jeremy P. Loenneke
Summary: The effects of blood flow restricted exercise on cognition are still unclear due to limited research in this area. The hypothesis suggests that blood flow restricted exercise could potentially enhance cognitive domains through increases in lactate production, catecholamine concentration, and PGC-1 alpha expression. Further investigations are needed to test this hypothesis.
MEDICAL HYPOTHESES
(2021)
Article
Medicine, General & Internal
Martina Del Giovane, William R. Trender, Maria Balaet, Emma-Jane Mallas, Amy E. Jolly, Niall J. Bourke, Karl Zimmermann, Neil S. N. Graham, Helen Lai, Ethan J. F. Losty, Garazi Arana Oiarbide, PeterJ. Hellyer, Irene Faiman, Sarah J. C. Daniels, Philippa Batey, Matthew Harrison, Valentina Giunchiglia, Magdalena A. Kolanko, Michael C. B. David, Lucia M. Li, Celia Demarchi, Daniel Friedland, David J. Sharp, Adam Hampshire
Summary: This observational study aimed to optimize an online cognitive assessment for use in traumatic brain injury (TBI) clinics. The online assessment successfully discriminated deficits in processing speed, visual attention, working memory, and executive function in TBI patients. Combining normative sociodemographic models and autogenerated reports, the online assessment has the potential to transform cognitive assessment in healthcare settings.
Article
Medicine, General & Internal
Danielle Sandalic, Yvonne Tran, Ashley Craig, Mohit Arora, Ilaria Pozzato, Grahame Simpson, Bamini Gopinath, Jasbeer Kaur, Sachin Shetty, Gerard Weber, Lisa Benad, James W. Middleton
Summary: The assessment of mild cognitive impairment (MCI) following spinal cord injury (SCI) is crucial, but there is a lack of specific neurocognitive screens for SCI and inconsistent criteria for determining rates of MCI. This study aimed to determine the suitability of a neurocognitive screen for assessing MCI in adults with SCI. The results showed that the current screen can differentiate between individuals with and without MCI, as well as MCI at different time points after injury. However, there are limitations in its suitability for assessing MCI after SCI, highlighting the need for a specialized neurocognitive screen for adults with SCI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nicolas W. Schuck, Amy X. Li, Dorit Wenke, Destina S. Ay-Bryson, Anika T. Loewe, Robert Gaschler, Yee Lee Shing
Summary: Children may perform worse than adults in tasks requiring focused attention, but their broader attentional focus may allow them to find novel solutions. A study found that 27.5% of 8-10-year-old children were able to completely change strategies, similar to the proportion of adults (28.2%) who had the same insight. However, children showed significant disadvantages in task execution and cognitive control.
Article
Clinical Neurology
Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma van der Ende, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A. L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonca, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Isabel Le Ber, Florence Pasquier, John C. van Swieten, Jonathan D. Rohrer
Summary: This study created cognitive composite scores for genetic frontotemporal dementia (FTD) and provided recommendations for recruitment and duration in clinical trial design.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Oncology
Annelise A. Madison, Rebecca Andridge, Anthony H. Kantaras, Megan E. Renna, Jeanette M. Bennett, Catherine M. Alfano, Stephen P. Povoski, Doreen M. Agnese, Maryam Lustberg, Robert Wesolowski, William E. Carson III, Nicole O. Williams, Raquel E. Reinbolt, Sagar D. Sardesai, Anne M. Noonan, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Depression combined with inflammation or intestinal permeability may contribute to poorer subjective and objective cognitive function in breast cancer survivors. These findings suggest that survivors with depression accompanied by immune dysregulation may be more aware of depression-related cognitive deficits compared to other depressed survivors.
Article
Biochemistry & Molecular Biology
Juan Angel Carrillo, Raul Arcusa, Maria Pilar Zafrilla, Javier Marhuenda
Summary: The study involving 108 healthy volunteers over a 16-week consumption period showed significant improvements in cognitive function by consuming a micronized fruit and vegetable-based preparation, particularly in areas such as short-term memory, verbal and non-verbal memory.
Article
Clinical Neurology
Hanna L. Sargenius, Stein Andersson, Ingvild Haugen, Ruth Hypher, Anne Elisabeth Brandt, Torun G. Finnanger, Torstein B. Ro, Kari Risnes, Jan Stubberud
Summary: This study reports a two-year follow-up investigation of goal management training (GMT) and psychoeducative control intervention (pBHW) on daily life executive function (EF) in children with acquired brain injury (ABI). The results showed that both interventions sustained improvements in daily life EF over the two-year follow-up period, but no additional effectiveness of GMT compared to pBHW was found.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Marianne Khalil, Philippine Hollander, Delphine Raucher-Chene, Martin Lepage, Katie M. Lavigne
Summary: Schizophrenia is characterized by cognitive impairments and structural brain abnormalities. Research suggests significant associations between brain structure and cognition, potentially following a functional network architecture.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Geriatrics & Gerontology
Emily Erlenbach, Edward McAuley, Neha P. Gothe
Summary: Existing evidence suggests a positive relationship between light-intensity physical activity (LPA) and cognition among adults, with potential benefits across adulthood. However, heterogeneous findings and inconsistent approaches indicate the need for a more unified scientific approach to understand the LPA-cognition relationship.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Neurosciences
Irene Aprile, Giulia Guardati, Valeria Cipollini, Dionysia Papadopoulou, Serena Monteleone, Alessandra Redolfi, Romina Garattini, Gianluigi Sacella, Fulvia Noro, Silvia Galeri, Maria Chiara Carrozza, Marco Germanotta
Summary: This study found that cognitive functions have an impact on the rehabilitation outcomes of stroke patients undergoing robotic upper limb rehabilitation. Deficits in spatial attention and executive functions affected improvement in daily living and mobility, while deficits in language, number processing, and spatial attention reduced gains in motor function.
Review
Biochemistry & Molecular Biology
Jeffrey Li, El-Sayed M. Abdel-Aal
Summary: Dietary lutein may lead to slight improvements in cognitive performance in the domains of complex attention, executive function, and memory, but the effect is not significant. However, it may play a role in maintaining cognitive performance in memory and executive function. More intervention studies are needed to further explore the potential benefits of lutein in preventing cognitive decline and promoting brain health.
Article
Clinical Neurology
Han Zhang, Yu Zhao, Yun Qu, Yunyun Huang, Zhu Chen, Hong Lan, Yi Peng, Hongying Ren
Summary: Cognitive impairment is a serious complication of traumatic brain injury (TBI) that impacts patients' quality of life. This study aims to investigate whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and executive function in TBI patients. A randomized controlled trial will be conducted with 36 participants, and neuropsychological assessments will be performed. The preliminary results suggest positive effects of rTMS on memory and executive function in TBI patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Renato Gondar, Gildas Patet, Karl Schaller, Torstein R. Meling
Summary: Assessment of cognition in brain tumor care is often overlooked in clinical outcomes, leading to potentially underestimated impact on patients' quality of life. Treatment for meningiomas can have early cognitive effects, but long-term conclusions are limited by short follow-up times. Standardized and reproducible cognitive testing should be a focus of future research to better understand the cognitive outcomes in meningioma patients, as cognitive dimensions and quality of life may be undervalued in clinical assessments.
Article
Geriatrics & Gerontology
Catherine Quinn, Sharon M. Nelis, Anthony Martyr, Robin G. Morris, Christina Victor, Linda Clare
AGING & MENTAL HEALTH
(2020)
Article
Geriatrics & Gerontology
Isla Rippon, Catherine Quinn, Anthony Martyr, Robin Morris, Sharon M. Nelis, Ian Rees Jones, Christina R. Victor, Linda Clare
AGING & MENTAL HEALTH
(2020)
Article
Geriatrics & Gerontology
Yu-Tzu Wu, Linda Clare, Fiona E. Matthews
Summary: This study aims to investigate the relationship between depressive symptoms in both people with dementia and their carers, finding that depressive symptoms have negative associations with capability to live well for both the individual and the partner. It also found that people with dementia who did not have a carer were more vulnerable to the impact of depressive symptoms.
AGING & MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Yu-Tzu Wu, Sharon M. Nelis, Catherine Quinn, Anthony Martyr, Ian R. Jones, Christina R. Victor, Martin Knapp, Catherine Henderson, John V. Hindle, Roy W. Jones, Michael D. Kopelman, Robin G. Morris, James A. Pickett, Jennifer M. Rusted, Jeanette M. Thom, Rachael Litherland, Fiona E. Matthews, Linda Clare
Review
Geriatrics & Gerontology
N. J. O'Shaughnessy, J. E. Chan, R. Bhome, P. Gallagher, H. Zhang, L. Clare, E. L. Sampson, P. Stone, J. Huntley
Summary: Our study found that lower level sensory awareness is relatively maintained in severe AD, while findings for higher level awareness are variable. Environmental and contextual factors have a significant impact on the presence of awareness in individuals with severe AD.
AGING & MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Christina R. Victor, Isla Rippon, Catherine Quinn, Sharon M. Nelis, Anthony Martyr, Nicola Hart, Ruth Lamont, Linda Clare
Summary: This study reveals a significant prevalence of moderate to severe loneliness among family caregivers of people with dementia, with factors such as social isolation, caregiving stress, relationship quality with the patient, and levels of well-being and life satisfaction being linked to loneliness. Over two-thirds of caregivers in the sample reported feeling lonely, suggesting that interventions focusing on reducing caregiving stress and promoting meaningful relationships may help alleviate loneliness.
AGING & MENTAL HEALTH
(2021)
Review
Geriatrics & Gerontology
Ilianna Lourida, Ruth Gwernan-Jones, Rebecca Abbott, Morwenna Rogers, Colin Green, Susan Ball, Anthony Hemsley, Debbie Cheeseman, Linda Clare, Darren Moore, Chrissy Hussey, George Coxon, David J. Llewellyn, Tina Naldrett, Jo Thompson Coon
Review
Geriatrics & Gerontology
Jason Weetch, Siobhan O'Dwyer, Linda Clare
Summary: People with dementia involved in advocacy face threats but respond with fighting back and making a difference, evolving their identities in the process. Dementia advocacy has positive impacts at individual, community, and societal levels, although there is a lack of research on broader aspects of advocates' identity and quantifying the impact.
AGING & MENTAL HEALTH
(2021)
Article
Neurosciences
Linda Clare, Anthony Martyr, Catherine Henderson, Laura Gamble, Fiona E. Matthews, Catherine Quinn, Sharon M. Nelis, Jennifer Rusted, Jeanette Thom, Martin Knapp, Nicola Hart, Christina Victor
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Geriatrics & Gerontology
Jacki Liddle, Avelie Stuart, Peter Worthy, Mark Levine, Tim Kastelle, Janet Wiles, Nancy A. Pachana, Linda Clare
Summary: This study explored the nature and quality of connections via technology among older people, revealing four key aspects including the caliber of connections, experiences of poor connection, reasons to connect, and strategies to enhance connection. Findings suggest that technology has become a part of social engagement for many individuals, and understanding the different characteristics and experiences of connection via technology is crucial in measuring social isolation and providing support for older adults.
CLINICAL GERONTOLOGIST
(2021)
Article
Gerontology
Mike C. Horton, Jan Oyebode, Linda Clare, Molly Megson, Leanne Shearsmith, Carol Brayne, Paul Kind, Zoe Hoare, Hareth Al Janabi, Val Hewison, Alan Tennant, Penny Wright
Summary: This study successfully developed three independent scales to measure the quality of life of dementia carers through a needs-led approach. The scales demonstrated robust measurement properties in terms of reliability, validity, responsiveness, and minimally important differences, meeting quality standards for study design and psychometrics.
Article
Neurosciences
Linda Clare, Anthony Martyr, Robin G. Morris, Lynette J. Tippett
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Gerontology
Catherine Talbot, Siobhan O'Dwyer, Linda Clare, Janet Heaton, Joel Anderson
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2020)
Review
Medicine, General & Internal
Vasiliki Orgeta, Kathryn R. McDonald, Ellen Poliakoff, John Vincent Hindle, Linda Clare, Iracema Leroi
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2020)
Review
Gerontology
Serena Sabatini, Barbora Silarova, Anthony Martyr, Rachel Collins, Clive Ballard, Kaarin J. Anstey, Sarang Kim, Linda Clare