Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Behavioral Sciences
Stefania Pezzoli, Raquel Sanchez-Valle, Aleix Solanes, Matthew J. Kempton, Oliver Bandmann, Jae Il Shin, Annachiara Cagnin, Jennifer G. Goldman, Doug Merkitch, Michael J. Firbank, John-Paul Taylor, Javier Pagonabarraga, Jaime Kulisevsky, Frederic Blanc, Norma Verdolini, Annalena Venneri, Joaquim Radua
Summary: The study found that visual hallucinations in patients with Parkinson's disease and dementia with Lewy bodies are associated with reductions in grey matter volume in certain brain regions, as well as lower verbal immediate memory performance in Parkinson's disease patients.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Maurizio Morelli, Marco D'Amelio, Aldo Quattrone, Grazia Annesi
Summary: The study aimed to evaluate LRP10 gene mutations in PD and DLB patients from Southern Italy, finding only 2 missense and 3 synonymous variants in patients and control subjects, and a rare variant p.L622F in a PD case. These results indicate that LRP10 mutations are not a common cause of PD and DLB in Southern Italy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Kurt A. Jellinger
Summary: PDD and DLB are two major neurocognitive disorders in the spectrum of Lewy body diseases with overlapping clinical and neuropathological features. DLB has higher Braak LB scores and neuritic Braak stages, as well as more severe neuropathological features like Thal A beta phases and neuritic Braak stages. Worse prognosis in DLB is linked to increased Braak neuritic stages and more severe cerebral amyloid angiopathy.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Rotem Iris Orad, Tamara Shiner
Summary: Dementia with Lewy bodies presents a diagnostic challenge due to clinical overlap with other neurodegenerative conditions, such as Parkinson's disease dementia and Alzheimer's disease. Neuroimaging plays a central role in improving diagnostic accuracy and management of this disorder.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Martyna M. Grochowska, Ana Carreras Mascaro, Valerie Boumeester, Domenico Natale, Guido J. Breedveld, Hanneke Geut, Wiggert A. van Cappellen, Agnita J. W. Boon, Anneke J. A. Kievit, Esther Sammler, Piero Parchi, Pietro Cortelli, Dario R. Alessi, Wilma D. J. van de Berg, Vincenzo Bonifati, Wim Mandemakers
Summary: Loss-of-function variants in the LRP10 gene are linked to Parkinson's disease, dementia, and other neurodegenerative disorders. LRP10 is highly expressed in astrocytes and interacts with SORL1, potentially playing a crucial role in vesicle trafficking pathways. The specific pattern of LRP10 incorporation into Lewy bodies suggests its involvement in neurodegenerative diseases.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Article
Clinical Neurology
Jing Xu, Jia Li, Ya-juan Sun, Wei Quan, Li Liu, Qing-hui Zhang, Yi-dan Qin, Xiao-chen Pei, Hang Su, Jia-jun Chen
Summary: In this study, mRNA expression profiles were analyzed to identify potential biomarkers and mechanisms distinguishing between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). Seven hub genes were found to be significantly associated with PDD, suggesting their involvement in the heterogeneous pathogenesis of PDD and DLB. Additionally, several signaling pathways related to different diseases were identified.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Noah J. Graves, Yann Gambin, Emma Sierecki
Summary: Like many neurodegenerative diseases, Parkinson's disease (PD) is characterized by the formation of proteinaceous aggregates in brain cells. Additionally, these aggregates are also found in other disorders, collectively referred to as synucleinopathies. Despite the diversity in pathologies and symptoms, aSyn aggregates are a common marker and potential driver of these diseases. This review compares PD, DLB, and MSA, highlighting the role of aSyn aggregates in each disorder and discussing the relationship between aSyn strains and the cellular environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Article
Neurosciences
Tatyana Dmitrievna Fedorova, Karoline Knudsen, Jacob Horsager, Allan K. Hansen, Niels Okkels, Hanne Gottrup, Kim Vang, Per Borghammer
Summary: The study compared the striatal dopaminergic dysfunction asymmetry between patients with dementia with Lewy bodies (DLB) and Parkinson's disease (PD). It found that DLB patients had more symmetric striatal degeneration compared to PD patients, which supports the hypothesis that DLB patients may conform to the body-first subtype while PD patients may conform to the brain-first subtype.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Shannon Y. Chiu, Kathryn A. Wyman-Chick, Tanis J. Ferman, Ece Bayram, Samantha K. Holden, Parichita Choudhury, Melissa J. Armstrong
Summary: This review summarizes the current knowledge on sex differences in dementia with Lewy bodies (DLB) in terms of epidemiology, clinical features, neuropathology, biomarkers, disease progression, and caregiving. The prevalence of DLB in men is higher in many studies, but this finding is inconsistent. Women with DLB may experience more visual hallucinations, while men may have a higher frequency of REM sleep behavior disorder and parkinsonism. Women tend to be older, have greater cognitive impairment, and meet DLB criteria later than men. The impact of sex on DLB progression and the lack of research on sex differences in biomarkers and treatment are mixed. Women provide the majority of caregiving in DLB, but the effects of this on the caregiving experience are uncertain. Understanding sex differences will aid in developing sex-specific strategies in DLB.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Geriatrics & Gerontology
Victor Calil, Andrea Silveira de Souza, Felipe Kenji Sudo, Gustavo Santiago-Bravo, Naima Assuncao, Claudia Drummond, Fernanda Rodrigues, Rejane Soares, Natalia Oliveira, Alina Teldeschi, Gabriel Bernardes, Gabriel Lima, Camila Lima, Marco Antonio Lima, Paulo Mattos
Summary: This study compared anosognosia for memory between individuals with DLB and dementia due to AD, finding that individuals with DLB had worse awareness of memory deficits. While there were no significant differences in age, education, sex, or disease duration between DLB and AD groups, DLB patients had a higher index of anosognosia compared to AD patients.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monte-Rubio, Merce Boada, Agustin Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Duezel, Octavio Rodriguez Gomez, Tammie Benzinger, Alison Goate, Celeste M. Karch, Anne M. Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suarez-Calvet, Christian Haass, Brian A. Gordon, Yen Ying Lim, Colin L. Masters, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Esther Milz, Sonia Moreno-Grau, Stefan Teipel, Michel J. Grothe, Ingo Kilimann, Martin Rossor, Nick Fox, Christoph Laske, Jasmeer Chhatwal, Peter Falkai, Robert Perneczky, Jae-Hong Lee, Annika Spottke, Henning Boecker, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J. Spruth, Christiana Franke, Anja Schneider, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel angel Araque Caballero, Coraline Metzger, Daniel Bittner, Stephen Salloway, Adrian Danek, Jason Hassenstab, Igor Yakushev, Peter R. Schofield, John C. Morris, Randall J. Bateman, Michael Ewers
Summary: The BDNFVal66Met mutation in Alzheimer's disease is associated with a greater impact on cognitive impairment, particularly through a decrease in hippocampal-medial-frontal connectivity. This finding was consistent across ADAD patients and elderly individuals with sporadically occurring Aβ, and was linked to lower global cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Meeting Abstract
Clinical Neurology
W. R. Chae, M. Fuentes Casan, F. Gutknecht, A. Ljubez, S. M. Gold, K. Wingenfeld, C. Otte
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Clinical Neurology
Victor Costumero, Lidon Marin-Marin, Marco Calabria, Vicente Belloch, Joaquin Escudero, Miguel Baquero, Mireia Hernandez, Juan Ruiz de Miras, Albert Costa, Maria-Antonia Parcet, Cesar Avila
ALZHEIMERS RESEARCH & THERAPY
(2020)
Article
Nutrition & Dietetics
L. M. P. d Wesselman, D. Melo van Lent, A. Schroeder, O. van de Rest, O. Peters, F. Menne, M. Fuentes, J. Priller, E. J. Spruth, S. Altenstein, A. Schneider, K. Fliessbach, S. Roeske, S. Wolfsgruber, L. Kleineidam, A. Spottke, V. Pross, J. Wiltfang, R. Vukovich, A. K. Schild, E. Duezel, C. D. Metzger, W. Glanz, K. Buerger, D. Janowitz, R. Perneczky, M. Tato, S. Teipel, I. Kilimann, C. Laske, M. Buchmann, A. Ramirez, S. A. M. Sikkes, F. Jessen, W. M. van der Flier, M. Wagner
Summary: In elderly individuals, adherence to Mediterranean and MIND diets was associated with better memory, while the 'alcoholic beverages' component was positively related to most cognitive domains. Exclusion of MCI subjects showed that Mediterranean and MIND diets were also related to language functions, with attenuated associations with the alcoholic beverages component.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Psychology, Clinical
Encarna Satorres, Itxasne Oliva, Joaquin Escudero, Juan C. Melendez
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2020)
Article
Neurosciences
Manuel Fuentes, Arne Klostermann, Luca Kleineidam, Chris Bauer, Johannes Schuchhardt, Wolfgang Maier, Frank Jessen, Lutz Froelich, Jens Wiltfang, Johannes Kornhuber, Stefan Kloeppel, Vera Schieting, Stefan J. Teipel, Michael Wagner, Oliver Peters
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Clinical Neurology
Steffen Wolfsgruber, Luca Kleineidam, Jannis Guski, Alexandra Polcher, Ingo Frommann, Sandra Roeske, Eike Jakob Spruth, Christiana Franke, Josef Priller, Ingo Kilimann, Stefan Teipel, Katharina Buerger, Daniel Janowitz, Christoph Laske, Martina Buchmann, Oliver Peters, Felix Menne, Manuel Fuentes Casan, Jens Wiltfang, Claudia Bartels, Emrah Duezel, Coraline Metzger, Wenzel Glanz, Manuela Thelen, Annika Spottke, Alfredo Ramirez, Barbara Kofler, Klaus Fliessbach, Anja Schneider, Michael T. Heneka, Frederic Brosseron, Dix Meiberth, Frank Jessen, Michael Wagner
Article
Neurosciences
Felix Menne, Carola Gertrud Schipke, Arne Klostermann, Manuel Fuentes-Casan, Silka Dawn Freiesleben, Chris Bauer, Oliver Peters
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Environmental Sciences
Juan C. Melendez, Encarnacion Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero
Summary: Using tDCS to increase true recognition and reduce false recognition in healthy older adults was effective in improving recall by increasing the number of items remembered and reducing memory errors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Juan C. Melendez, Alfonso Pitarque, Iraida Delhom, Elena Real, Mireia Abella, Encarnacion Satorres
Summary: The study found significant longitudinal deterioration in autobiographical memory in patients with mild cognitive impairment and Alzheimer's disease, while healthy older adults did not show significant changes over time. The deterioration of both episodic and semantic memory was confirmed in Alzheimer's disease, with a pattern of deterioration observed in semantic autobiographical memory for patients with mild cognitive impairment over an eighteen-month period.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Manuel Fuentes, Alicia Sales, Marina Charquero-Ballester, Gracian Garcia-Marti, Juan Carlos Melendez, Raul Espert, Michael Scheel, Hans-Christian Bauknecht, Katja Simon, Uta Koepstein, Sibylle Gebauer, Salvador Algarabel
Summary: Recognition memory is a dual process-based model consisting of familiarity and recollection. This study investigated the importance of the fornix in recognition memory through the examination of a patient who underwent bilateral fornix section. The results suggest that the fornix plays a role in recollection memory and may be associated with the recovery of non-verbal memory.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Environmental Sciences
Encarnacion Satorres, Juan C. Melendez, Alfonso Pitarque, Elena Real, Mireia Abella, Joaquin Escudero
Summary: This study aimed to analyze the effect of two 20-min sessions of anodal transcranial direct stimulation on immediate memory, learning potential, and working memory in healthy older adults. The results showed that tDCS is a non-invasive and safe tool to enhance cognitive processes in healthy older adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Clinical
Manuel Fuentes, Carola G. Schipke, Silka Dawn Freiesleben, Arne Klostermann, Oliver Peters
Summary: This study describes the clinical characteristics of a German male with early-onset Alzheimer's disease caused by a M139V mutation in the presenilin 1 gene. The patient has several affected family members, suggesting a potential role of the mutation in modulating the phenotype.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Endocrinology & Metabolism
Woo Ri Chae, Manuel Fuentes-Casan, Felix Gutknecht, Angela Ljubez, Stefan M. Gold, Katja Wingenfeld, Christian Otte
Summary: Early-onset (EOD) and late-onset (LOD) late-life depression may differ in etiology, clinical features, and treatment response, with EOD more commonly associated with family history of affective disorders and personality aspects, while LOD is thought to be more strongly driven by acquired cerebrovascular risk factors. However, in a systematic review, the only difference between EOD and LOD was the frequency of affective disorders in family history.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychology, Multidisciplinary
Alfonso Pitarque, Encarnacion Satorres, Joaquin Escudero, Salvador Algarabel, Juan C. Melendez