Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Critical Care Medicine
Amelia J. Hicks, Fiona J. Clay, Malcolm Hopwood, Amelia C. James, Luke A. Perry, Mahesh Jayaram, Rachel Batty, Jennie L. Ponsford
Summary: Research on pharmacological interventions for anxiety after TBI is currently limited, with only a few studies available, making it difficult to provide clear recommendations on pharmacotherapy. Future studies should focus on conducting more adequately powered and controlled research on pharmacological interventions for anxiety symptoms after TBI to gain a better understanding of their effectiveness.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Critical Care Medicine
Gustavo C. Medeiros, Claire Twose, Alexandra Weller, John W. Dougherty, Fernando S. Goes, Haris I. Sair, Gwenn S. Smith, Durga Roy
Summary: Depression after traumatic brain injury (TBI) is associated with neuroimaging measures such as lower gray matter and greater white matter damage. However, there is currently no clear neuroimaging biomarker for diagnosing and treating depression after TBI. Further research is needed in this area.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Clinical Neurology
John Gerrard Hanrahan, Charlotte Burford, Palani Nagappan, Gideon Adegboyega, Shivani Rajkumar, Angelos Kolias, Adel Helmy, Peter John Hutchinson
Summary: This article systematically reviews the association between traumatic brain injury (TBI) and dementia. It finds a relationship between the two, but cannot determine the risk of dementia for an individual following TBI. The article also highlights limitations and issues in current studies and suggests using standardized methods to define TBI, establish criteria for dementia diagnosis, and conduct longer-term follow-up studies.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Grace M. Turner, Christel McMullan, Olalekan Lee Aiyegbusi, Danai Bem, Tom Marshall, Melanie Calvert, Jonathan Mant, Antonio Belli
Summary: This study found that traumatic brain injury is an independent risk factor for stroke, with patients experiencing significantly increased risk of stroke post-traumatic brain injury which may persist up to five years. Meta-analysis results also indicate that traumatic brain injury may increase the risk of stroke, and certain medications may be associated with either reduced or increased risk of stroke.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Review
Clinical Neurology
Jeremy A. Feiger, Rachael L. Snyder, Michael J. Walsh, Mackenzie Cissne, Andrew Cwiek, Seima I. Al-Momani, Kathy S. Chiou
Summary: This review explores the role of neuroinflammation and immune response in the development of neuropsychiatric disorders after traumatic brain injury (TBI). The study findings indicate that neuroinflammation is associated with neuropsychiatric disorders such as anxiety, trauma/stress, and depression post-TBI. Inflammatory processes and stress response dysregulation may lead to secondary cell damage, promoting the development and maintenance of these disorders.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Computer Science, Artificial Intelligence
Alejandro Moya, Elena Pretel, Elena Navarro, Javier Jaen
Summary: The increasing number of people with traumatic brain injury (TBI) presents a challenge for practitioners in designing the rehabilitation process due to their multiple deficits. This study focuses on analyzing the clustering algorithms used to group TBI patients and aims to determine the purposes, deficits, algorithms, features, data pre-processing techniques, parameters, and efficiency/effectiveness achieved by these algorithms.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Review
Clinical Neurology
Alex S. Aguirre, Kenny Rojas, Alcy R. Torres
Summary: Our study reveals that head injuries are the most common casualties in war zones, affecting both male and female children with an average age of 8-10 years. Most children are from Afghanistan, and blasts are the most common mechanism of injury, with a mortality rate ranging from 3% to 47%.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anastasia A. Vasilieva, Elena E. Timechko, Kristina D. Lysova, Anastasia I. Paramonova, Alexey M. Yakimov, Elena A. Kantimirova, Diana V. Dmitrenko
Summary: Structural or post-traumatic epilepsy often develops after brain tissue damage caused by traumatic brain injury, stroke, infections of the brain, etc. MicroRNAs, such as miR-21, miR-181a, and miR-155, show potential as biomarkers for predicting epileptogenesis. However, more in-depth and prolonged studies are needed to understand the process of epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Critical Care Medicine
Petra Avramovic, Rachael Rietdijk, Michelle Attard, Belinda Kenny, Emma Power, Leanne Togher
Summary: This review evaluates and synthesizes the use of digital health interventions in traumatic brain injury (TBI) rehabilitation and caregiver education. The results indicate that digital health interventions have positive effects on improving communication, social, psychological, and cognitive skills of people with TBI and their caregivers. However, there is a need for improved methodological rigor, clear intervention characteristics, and further research on multi-modal digital health interventions.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Chemistry, Multidisciplinary
George R. E. Bradley, Maria Roldan, Panayiotis A. Kyriacou
Summary: This systematic review aimed to predict intracranial pressure (ICP) crises in patients with severe traumatic brain injury (TBI) in order to prevent secondary brain injury and improve patient outcomes. The review identified three effective approaches: long short-term memory (LSTM), Gaussian processes (GP), and logistic regression models, with area under the receiver operating characteristics curve (AUC-ROC) ranging from 0.86 to 0.95. The review also highlighted the lack of consensus on the definition of an ICP crisis, the most clinically relevant prediction horizon, and the clinical intelligibility, improvement of patient care, and ethical concerns of algorithms.
APPLIED SCIENCES-BASEL
(2023)
Article
Rehabilitation
Sheryl Katta-Charles, Leah M. Adams, Nancy D. Chiaravalloti, Flora M. Hammond, Paul B. Perrin, Amanda R. Rabinowitz, Umesh M. Venkatesan, Alan H. Weintraub, Charles H. Bombardier
Summary: The study aimed to investigate the prevalence, severity, and correlates of depression, anxiety, and suicidal ideation in individuals with traumatic brain injury (TBI) before and during the COVID-19 pandemic. The findings showed no significant differences in depression, anxiety, or suicidal ideation before vs during the pandemic, and the predictors of mental health outcomes remained similar. The results suggest a general resilience and are consistent with recent studies in the general population, indicating only temporary increases in psychological distress associated with the pandemic. Although not worsened, depression, anxiety, and suicidal ideation are still prevalent and require focused treatment and research efforts.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Critical Care Medicine
Laura M. Heath, M. Rafae Kidwai, Brenda Colella, Georges Monette, Pavel Tselichtchev, Jennifer C. Tomaszczyk, Robin E. Green
Summary: This study examined the long-term trajectories of anxiety and depressive symptoms following moderate-severe traumatic brain injury (TBI), identified predictors of these trajectories, and explored their impact on 1-year return to productivity. The findings showed that there were four distinct trajectories for anxiety and depression, with most individuals experiencing stable or low levels over time. However, a subset of individuals showed rapid worsening of anxiety or depression, and those with worsening symptoms were less likely to return to productivity by 1-year post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Health Care Sciences & Services
Sylvie Lambert, Lydia Ould Brahim, Jane McCusker, Chelsea Coumoundouros, Li-Anne Audet, Mark Yaffe, John Kayser, Mona Magalhaes, Eric Belzile, Nerida Turner
Summary: Non-pharmacological interventions show improvement in depression and anxiety symptoms in caregivers, especially in the short term, by enhancing caregivers' self-management skills such as taking action, problem-solving, and decision-making. Future interventions should focus on enhancing the effect of these interventions, particularly by examining the impact of booster sessions. More research is needed on non-dementia caregiving and dyadic approaches.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Neurosciences
Shazia Malik, Omar Alnaji, Mahnoor Malik, Teresa Gambale, Michel Piers Rathbone
Summary: This study found through a systematic review that neuroinflammatory cytokines associated with mild traumatic brain injuries are related to emotional impairments such as depression, anxiety, and post-traumatic stress disorder (PTSD). IL-6, TNF alpha, IL-10, and CRP are the most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population.
Review
Health Care Sciences & Services
Jane Topolovec-Vranic, Karthik Natarajan
JOURNAL OF MEDICAL INTERNET RESEARCH
(2016)
Article
Immunology
Alex P. Di Battista, Shawn G. Rhind, Michael G. Hutchison, Syed Hassan, Maria Y. Shiu, Kenji Inaba, Jane Topolovec-Vranic, Antonio Capone Neto, Sandro B. Rizoli, Andrew J. Baker
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Clinical Neurology
Donna Ouchterlony, Cheryl Masanic, Alicja Michalak, Jane Topolovec-Vranic, John A. Rutka
JOURNAL OF NEUROSCIENCE NURSING
(2016)
Article
Psychiatry
Jane Topolovec-Vranic, Andree Schuler, Agnes Gozdzik, Julian Somers, Paul-Emile Bourque, C. James Frankish, Jalila Jbilou, Sarah Pakzad, Luis Ivan Palma Lazgare, Stephen W. Hwang
JOURNAL OF PSYCHIATRIC RESEARCH
(2017)
Review
Multidisciplinary Sciences
Tian Renton, Alana Tibbles, Jane Topolovec-Vranic
Article
Critical Care Medicine
Celine Gelinas, Kathleen A. Puntillo, Madalina Boitor, Melanie Berube, Jane Topolovec-Vranic, Anne-Sylvie Ramelet, Aaron M. Joffe, Melissa Richard-Lalonde, Francis Bernard, David L. Streiner
AUSTRALIAN CRITICAL CARE
(2018)
Article
Health Care Sciences & Services
Celine Gelinas, Madalina Boitor, Kathleen A. Puntillo, Caroline Arbour, Jane Topolovec-Vranic, Michael D. Cusimano, Manon Choiniere, David L. Streiner
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2019)
Article
Clinical Neurology
Michael D. Cusimano, Stanley Zhang, Jane Topolovec-Vranic, Ashley Grosso, Rowan Jing, Gabriela Ilie
FRONTIERS IN NEUROLOGY
(2018)
Article
Public, Environmental & Occupational Health
Amanda Formosa, Isabelle Dobronyi, Jane Topolovec-Vranic
Summary: This study assessed the educational needs of homeless care providers in recognizing and managing traumatic brain injuries (TBI). Frontline workers expressed a moderate level of confidence in identifying and managing TBI, indicating the value of educational initiatives in this context. Improved education for shelter workers may benefit their clients' health outcomes by increasing knowledge in identifying and managing TBI-related symptoms.
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Teresa J. Valenzano, Daniela Bellicoso, Sara Morassaei, Jane Topolovec-Vranic, Katie Churchill, Nicole Thomson, Alexandra Harris, Lianne Jeffs, Lisa Di Prospero
Summary: The Canadian Practice-Based Research Network (CP-BRN) is a collective of representatives from various practice-based research programs aimed at advancing evidence-based practice. This paper provides an overview of CP-BRN's development, proceedings from its inaugural meeting, and recommendations for nursing and allied health profession leaders considering their own practice-based research programs. The next steps for the network include raising awareness, expanding membership, and further advancing evidence-based practice in healthcare and academic institutions.
JOURNAL OF MEDICAL IMAGING AND RADIATION SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ifat Witz, Stephanie Lucchese, Teresa J. Valenzano, Tasha Penney, Rachel Lodge, Jane Topolovec-Vranic, Daniela Bellicoso
Summary: This article reports on an evaluation of the outcomes of using a standardized reporting tool and structured rounding process to improve efficiency and communication in patient care. While focusing on nurses' opinions, this example can serve as a model for leadership in other healthcare units.
JOURNAL OF MEDICAL IMAGING AND RADIATION SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela Bellicoso, Teresa J. Valenzano, Jane Topolovec-Vranic
Summary: This study found that a manuscript writing workshop effectively increased nursing and health discipline clinicians' self-perceived confidence in manuscript writing, providing a supportive environment and mentorship.
JOURNAL OF MEDICAL IMAGING AND RADIATION SCIENCES
(2022)
Article
Medicine, General & Internal
Adriana M. Workewych, Madeline Ciuffetelli Muzzi, Rowan Jing, Stanley Zhang, Jane Topolovec-Vranic, Michael D. Cusimano
SAGE OPEN MEDICINE
(2017)
Article
Medicine, General & Internal
Michael D. Cusimano, Stanley Zhang, Jane Topolovec-Vranic, Michael G. Hutchison, Rowan Jing
SAGE OPEN MEDICINE
(2017)
Article
Orthopedics
Michael D. Cusimano, Jane Topolovec-Vranic, Stanley Zhang, Sarah J. Mullen, Mattew Wong, Gabriela Ilie
CLINICAL JOURNAL OF SPORT MEDICINE
(2017)