Review
Psychiatry
Megan Snelleksz, Susan L. Rossell, Andrew Gibbons, Jess Nithianantharajah, Brian Dean
Summary: Research suggests that the frontal pole is significantly impacted in schizophrenia, with more gene expression changes compared to other brain regions. The frontal pole is essential for higher cognitive functions and has extensive connections with various brain regions. Dysfunction in the frontal pole plays a crucial role in the pathophysiology of schizophrenia, with structural, cellular, and molecular abnormalities contributing to the symptoms of the disorder.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Bryan Kolb
Summary: This article discusses Milner's contribution to our understanding of frontal lobes through her studies on patients who had undergone frontal lobe excisions. Her research has had a significant impact on our understanding of frontal lobe function.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Soojin Kim, Seong-Wook Kim, Mai Anh Thi Bui, Yeji Kim, Minsoo Kim, Jung-Cheol Park, Nam-Heon Kim, Gyeong Hee Pyeon, Yong Sang Jo, Jaewon Jang, Hae-Young Koh, Chae-Hong Jeong, Moonkyung Kang, Hyo Jung Kang, Yong-Woo Lee, Craig A. Stockmeier, Je Kyung Seong, Dong Ho Woo, Jung-Soo Han, Yeon-Soo Kim
Summary: Previous studies have shown the upregulation of SELENBP1 in the prefrontal cortex of schizophrenia patients, but no causal connection has been established. This study provides evidence linking the upregulation of SELENBP1 with negative symptoms of schizophrenia in mice. The results suggest that increased SELENBP1 levels in the prefrontal cortex lead to social withdrawal and other negative behaviors associated with schizophrenia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Clement M. Garin, Marie Garin, Leonardo Silenzi, Rye Jaffe, Christos Constantinidis
Summary: The size of the prefrontal cortex in humans is not disproportionately enlarged compared to other catarrhini species. However, humans have the most relatively enlarged frontal and parietal lobes in an infraorder exhibiting a disproportionate expansion of these areas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Rihui Li, Jennifer L. Bruno, Tracy Jordan, Jonas G. Miller, Cindy H. Lee, Kristi L. Bartholomay, Matthew J. Marzelli, Aaron Piccirilli, Amy A. Lightbody, Allan L. Reiss
Summary: This study reveals a specific pattern of brain activation and habituation in response to face stimuli in young girls with fragile X syndrome (FXS) using functional near-infrared spectroscopy. The findings strongly support the hypothesis of neural hyperactivation and accentuated sensitization during face processing in FXS, which could be developed as a biomarker for evaluating treatment trials in girls with this condition.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Multidisciplinary Sciences
Victor Oswald, Younes Zerouali, Aubree Boulet-Craig, Maja Krajinovic, Caroline Laverdiere, Daniel Sinnett, Pierre Jolicoeur, Sarah Lippe, Karim Jerbi, Philippe Robaey
Summary: In this study, the specificity of the resting state MEG correlates of the executive and language components in verbal fluency were investigated. The results showed that slow clusters in the right hemisphere, including premotor, pre-central, and post-central cortex, were associated with executive monitoring, while slow parietal clusters and a cluster in the left inferior frontal gyrus were likely involved in phonological processing related to verbal fluency.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Kentaro Miyamoto, Nadescha Trudel, Kevin Kamermans, Michele C. Lim, Alberto Lazari, Lennart Verhagen, Marco K. Wittmann, Matthew F. S. Rushworth
Summary: More than one type of probability must be considered when making decisions. There are internal and external probabilities that impact neural activity and decision-making processes, with the anterior lateral prefrontal cortex playing a key role in metacognitive judgments based on internal probability. disruptions in this area can alter metacognitive judgments and decision-making processes.
Article
Neurosciences
Suzanne N. Haber, Julia Lehman, Chiara Maffei, Anastasia Yendiki
Summary: This study explores the role of the zona incerta (ZI) in mediating top-down and bottom-up control, and its potential for deep brain stimulation for obsessive-compulsive disorder. It reveals that the ZI is a hub for connecting cognitive control areas and subcortical structures, such as the lateral habenula and substantia nigra/ventral tegmental area.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Feng Deng, Nicola Taylor, Adrian M. M. Owen, Rhodri Cusack, Lorina Naci
Summary: Anaesthesia combined with functional neuroimaging is useful for understanding the brain mechanisms of consciousness. Propofol, a commonly used anesthetic, shows large inter-individual variability in suppressing consciousness, and the brain bases of this variability remain poorly understood.
HUMAN BRAIN MAPPING
(2023)
Review
Anatomy & Morphology
Nicholas B. B. Dadario, Onur Tanglay, Michael E. E. Sughrue
Summary: Brodmann area 8 (BA8) is the prefrontal region of the human cerebrum that controls contralateral gaze and attention, but recent studies have challenged this traditional definition and revealed its involvement in motor, cognition, and language functions. Advances in neuroimaging have allowed for better understanding of the structural and functional connectivity of BA8, which is crucial for complex neurological functioning and pathophysiological diseases states. However, further review is needed to fully comprehend the importance of the underlying connectivity of BA8.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Biology
Kasra Manoocheri, Adam G. Carter
Summary: Connections from the basolateral amygdala to medial prefrontal cortex regulate memory and emotion, and disruptions to these connections can occur in neuropsychiatric disorders. This study reveals how different subregions of the basolateral amygdala target distinct networks within the prefrontal cortex, influencing memory and emotion regulation.
Article
Cell Biology
Christian M. Wood, Laith Alexander, Johan Alsio, Andrea M. Santangelo, Lauren McIver, Gemma J. Cockcroft, Angela C. Roberts
Summary: Poor outcomes are common in anxiety and depression, thus understanding the neural circuits underlying symptoms and treatment responses is important. By using a chemogenetics strategy involving designer receptors and drugs, the scACC-25 neural circuits related to anhedonia and anxiety in marmosets were identified. Targeting these circuits with the fast-acting antidepressant ketamine may lead to new treatment strategies.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Steliana Yanakieva, Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Summary: This study compared collateral projections from different rostral thalamic nuclei terminating in different cortical areas. The results showed that these projections predominantly arise from separate populations of neurons with discrete cortical termination zones.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Bin A. Wang, Maike Veismann, Abhishek Banerjee, Burkhard Pleger
Summary: The study reveals that the orbitofrontal cortex (OFC) interacts with the primary somatosensory cortex (S1) to guide flexible tactile learning in humans. The OFC has transient responses to unexpected outcomes, while the S1 is persistently engaged during re-learning. These findings suggest that the OFC contributes to dynamically updating representations in sensory areas through top-down signals to implement computations critical for adaptive behavior.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Avinash R. Vaidya, Henry M. Jones, Johanny Castillo, David Badre
Summary: The study uncovered how the human brain adapts flexibly to new conditions without feedback, confirming the existence of a neural instantiation of an abstract task representation. This representation can support massive expansions of behavioral flexibility in human cognition.
Article
Biology
Chris Foulon, Leonardo Cerliani, Serge Kinkingnehun, Richard Levy, Charlotte Rosso, Marika Urbanski, Emmanuelle Volle, Michel Thiebaut de Schotten
Article
Pharmacology & Pharmacy
Theophile Bieth, Marcela Ovando-Tellez, Matthieu Bernard, Emmanuelle Volle
ANNALES MEDICO-PSYCHOLOGIQUES
(2019)
Review
Behavioral Sciences
Marcela P. Ovando-Tellez, Theophile Bieth, Matthieu Bernard, Emmanuelle Volle
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2019)
Letter
Psychology, Biological
Christiane Schreiweis, Emmanuelle Volle, Alexandra Durr, Alexandra Auffret, Cecile Delarasse, Nathalie George, Magali Dumont, Bassem A. Hassan, Nicolas Renier, Charlotte Rosso, Michel Thiebaut de Schotten, Eric Burguiere, Violetta Zujovic
NATURE HUMAN BEHAVIOUR
(2019)
Editorial Material
Neurosciences
Manish Saggar, Emmanuelle Volle, Lucina Q. Uddin, Evangelia G. Chrysikou, Adam E. Green
Article
Neurosciences
Marcela Ovando-Tellez, Benjamin Rohaut, Nathalie George, Theophile Bieth, Laurent Hugueville, Yoan Ibrahim, Ophelie Courbet, Lionel Naccache, Richard Levy, Beatrice Garcin, Emmanuelle Volle
Summary: Categorization is a critical cognitive process for human thinking and reasoning, and can be measured through similarity tasks. The study found that a double semantic priming paradigm can enhance categorization effects, providing insights into the organization of semantic memory categories.
COGNITIVE NEUROSCIENCE
(2022)
Meeting Abstract
Psychology, Biological
Theophile Bieth, Marcela Ovando-Tellez, Alizee Lopez-Persem, Beatrice Garcin, Laurent Hugueville, Katia Lehongre, Nathalie George, Emmanuelle Volle
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Marcela Ovando-Tellez, Yoed N. Kenett, Mathias Benedek, Matthieu Bernard, Joan Belo, Benoit Beranger, Theophile Bieth, Emmanuelle Volle
Summary: This study explores the relationship between creativity and the structure of semantic memory by examining individual semantic memory networks and brain connectivity patterns. The results demonstrate the significant role of functional connectivity in supporting real-life creative behavior through the structure of semantic memory.
Article
Behavioral Sciences
Valentine Facque, Antonius Wiehler, Emmanuelle Volle, Emmanuel Mandonnet, Mathias Pessiglione
Summary: Fatigue is a common symptom in many clinical conditions, but its understanding is still limited. This study used model-based analysis to identify fatigue markers. The results showed that patients with low-grade glioma were more prone to impulsive choices during decision-making, reflecting the impact of glioma on brain functioning.
Article
Psychology, Multidisciplinary
Alizee Lopez-Persem, Theophile Bieth, Stella Guiet, Marcela Ovando-Tellez, Emmanuelle Volle
Summary: COVID-19 lockdown led to changes in creativity among the French speaking population. Despite negative subjective experiences, participants reported increased creativity during the lockdown. Positive changes were associated with more available time, motivation, and problem-solving needs, while negative changes were linked to negative emotions and a lack of resources and opportunities.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Neurosciences
Margaux Poireau, Thomas Milpied, Angeline Maillard, Christine Delmaire, Emmanuelle Volle, Frank Bellivier, Romain Icick, Julien Azuar, Cynthia Marie-Claire, Vanessa Bloch, Florence Vorspan
Summary: This study reviewed the biomarkers associated with relapse in cocaine use disorder (CUD) and summarized the current research findings. The results showed that brain imaging and neuropsychological factors play an important role in predicting abstinence, but there are still other biomarkers that need further investigation. The authors called for future prospective studies using combined multimodal assessments.
Article
Biology
Marcela Ovando-Tellez, Mathias Benedek, Yoed N. Kenett, Thomas Hills, Sarah Bouanane, Matthieu Bernard, Joan Belo, Theophile Bieth, Emmanuelle Volle
Summary: Creative ideas likely result from searching and combining semantic memory knowledge. Switching and clustering in the search process are related to cognitive and neural processing. Switching is correlated with the ability to combine remote associates and semantic memory structure, while clustering is correlated with divergent thinking and attentional control.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neuroimaging
Delphine Tanguy, Benedicte Batrancourt, Alfonso Estudillo-Romero, John S. H. Baxter, Isabelle Le Ber, Arabella Bouzigues, Valerie Godefroy, Aurelie Funkiewiez, Celine Chamayou, Emmanuelle Volle, Dario Saracino, Armelle Rametti-Lacroux
Summary: Disinhibition is a core symptom of many neurodegenerative diseases, particularly frontotemporal dementia. This study used a semi-ecological situation to assess behavioural disinhibition and found that patients with frontotemporal dementia exhibited more compulsivity and social disinhibition than controls. The behavioural metrics were related to cognitive performance, with compulsivity correlated with semantic appraisal network and social disinhibition associated with the frontal component of the salience network.
NEUROIMAGE-CLINICAL
(2022)
Article
Behavioral Sciences
Emmanuel Mandonnet, Marion Vincent, Antoni Valero-Cabre, Valentine Facque, Marion Barberis, Francois Bonnetblanc, Francois Rheault, Emmanuelle Volle, Maxime Descoteaux, Daniel S. Margulies
Article
Biology
Pedro Nascimento Alves, Chris Foulon, Vyacheslav Karolis, Danilo Bzdok, Daniel S. Margulies, Emmanuelle Volle, Michel Thiebaut de Schotten
COMMUNICATIONS BIOLOGY
(2019)