Review
Clinical Neurology
Elliot H. Choi, Alvin Y. Chan, Nolan J. Brown, Brian V. Lien, Ronald Sahyouni, Andrew K. Chan, John Roufail, Michael Y. Oh
Summary: The combination of primary closure and patches or grafts has been found to be effective in reducing postoperative CSF leakage rates, while sealants as an adjunct did not significantly decrease this risk.
WORLD NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Rong-Peng Dong, Qi Zhang, Li-Li Yang, Xue-Liang Cheng, Jian-Wu Zhao
Summary: Dural defects are common in neurosurgery and can lead to complications such as cerebrospinal fluid leakage. This review comprehensively summarizes the causes, risk factors, complications, and repair methods of dural defects. It also discusses the latest research on dural repair materials and methods, including sutures, grafts, biomaterials, non-biomaterials, and composites. The characteristics and efficacy of these substitutes are evaluated, and the challenges and future prospects of new materials are discussed.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Clinical Neurology
Lei Jiang, Alexandru Budu, Muhammad Shuaib Khan, Edward Goacher, Angelos Kolias, Rikin Trivedi, Jibin Francis
Summary: The effectiveness of different dural closure techniques in preventing cerebrospinal fluid leaks following surgery for intradural lesions was compared in this study. It was found that age, surgical indication, and dural closure with suture, sealant, and patch were factors associated with CSF leaks.
Article
Surgery
Ahmed Fawzy, M. Ashraf Balbaa, Ahmed Gaber
Summary: The study showed that using fibrin glue in inguinal lymph node dissection significantly reduced the incidence of seroma formation, total amount of serous fluid, time to remove drains, and hospital stay. However, there were no significant differences between the two groups in occurrences of hematoma, infection or superficial skin edge necrosis. Future studies need to standardize the definition of seroma and determine the optimal dosage and technique of fibrin glue in ILND.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, Hideto Kojima
Summary: This article investigates the regenerating effect of gelatin sponges as scaffolds in deep wounds with periosteal defects in rats. The study demonstrates that the microenvironment provided by the gelatin sponges enables bone marrow-derived cells to form a vascular niche, leading to the regeneration of periosteum, skin, and skin appendages. These findings emphasize the importance of vascular niche formation in the regeneration of heterogeneous tissues in deep wounds.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
A. Kinaci, S. van Thoor, S. Redegeld, M. Tooren, T. P. C. van Doormaal
Summary: This study demonstrates that Liqoseal is capable of achieving a strong watertight seal over a dural defect in ex vivo models.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Surgery
Kartik Shenoy, Chester J. Donnally, Evan D. Sheha, Krishn Khanna, Srinivas K. Prasad
Summary: A novel dural repair device was compared to traditional tools in a clinical simulation model, showing better performance in repair time, CSF leak pressure, and nerve root avoidance. While the results were generally replicable in clinical settings, the simulation model had limitations in capturing all clinical scenarios.
FRONTIERS IN SURGERY
(2021)
Review
Clinical Neurology
Ahmed Albayar, Michael Spadola, Rachel Blue, Anissa Saylany, Mert Marcel Dagli, Gabrielle Santangelo, Connor Wathen, Yohannes Ghenbot, Dominick Macaluso, Zarina S. Ali, Ali K. Ozturk, William C. Welch
Summary: This study reviewed incidental durotomies, a common complication of spine surgery, and summarized the treatment strategies and management algorithm. The results showed a lack of standardized approaches to manage such complications, and the goal of this article is to contribute to the development of treatment consensus.
GLOBAL SPINE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Jiafu Mu, Jiahe Wu, Jian Cao, Teng Ma, Liming Li, Shiqing Feng, Jianqing Gao
Summary: This study evaluates an emergency cell-free treatment using mesenchymal stem cell-derived exosomes for traumatic spinal cord injury, which has been shown to comprehensively mitigate the inhibitory lesion microenvironment, providing a promising strategy for effective emergency treatment of central nervous system trauma.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Clinical Neurology
Mohamed A. R. AbdelFatah
Summary: This study investigated the incidence of persistent cerebrospinal fluid (CSF) leak from incidental dural tears after using acetazolamide, short bed rest, and subfascial off-suction drainage. The results showed that there were no cases of wound infection, collection, or persistent CSF leakage in any of the 74 patients during the 6-month follow-up period. A prospective placebo-controlled study is needed to confirm the efficacy of acetazolamide in preventing CSF leakage.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Clinical Neurology
Teresa Haugaard Nielsen, Mikkel Mylius Rasmussen, Mathias Moller Thygesen
Summary: Incidental durotomy (ID) is one of the common complications in degenerative surgery, with a prevalence of around 10.4% in this study. Increasing age, revision surgery, and decompression of multiple levels are identified as risk factors for ID.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Jiajing Ye, Zhenghua Hong, Binxiang Chu, Zhangfu Wang, Lingjun Jiang, Zhong Zhu, Zhongyi Chen
Summary: Study aimed to compare different suture types and adhesives to reduce cerebrospinal fluid leakage after spinal surgery. Vicryl sutures significantly reduced CSFL occurrence in both animal model and clinical study. Fibrin glue can reinforce dural repair and reduce CSFL.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Tarika Goncalves do Carmo Oliveira, Ana Claudia Moreira dos Santos, Alex Dias Assis, Raphael Teixeira Borges, Jessica Regina da Costa Silva, Carlos Ueira-Vieira, Gustavo Ferreira Simoes, Renata Graciele Zanon
Summary: The combination of BthTL glue and TNF mimetic peptide promoted axonal regrowth and remyelination, leading to better regeneration outcomes. The Tube + Glue + Pep group exhibited intense inflammatory infiltrate, higher expression of NGFRp75 receptor, increased myelin thickness and fiber diameter, as well as more type III collagen deposition.
BRAIN RESEARCH BULLETIN
(2021)
Review
Cell Biology
Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Karina Torres Pomini, Carlos Henrique Bertoni Reis, Cleuber Rodrigo de Souza Bueno, Eliana de Souza Bastos Mazuqueli Pereira, Jessica de Oliveira Rossi, Paulo Cezar Novais, Joao Paulo Galletti Pilon, Geraldo Marco Rosa Junior, Daniela Vieira Buchaim, Rogerio Leone Buchaim
Summary: The utilization of MSCs combined with fibrin glue has shown promising results in regenerative medicine, with benefits in tissue healing, angiogenesis, anti-apoptosis, and immunomodulation. Literature provides clear evidence that fibrin glue loaded with MSCs, either alone or in combination with bone substitute, is a promising strategy for treating bone or cartilaginous tissue lesions.
Article
Engineering, Biomedical
Jonathan H. Galarraga, Hannah M. Zlotnick, Ryan C. Locke, Sachin Gupta, Natalie L. Fogarty, Kendall M. Masada, Brendan D. Stoeckl, Lorielle Laforest, Miguel Castilho, Jos Malda, Riccardo Levato, James L. Carey, Robert L. Mauck, Jason A. Burdick
Summary: Soft norbornene-modified hyaluronic acid (NorHA) hydrogels were reinforced with polycaprolactone using melt electrowriting (MEW) to fabricate composite scaffolds. These scaffolds supported chondrogenesis and cartilage formation of encapsulated porcine mesenchymal stromal cells (pMSC) and exhibited suitable mechanical properties. Fixation of the composites with biodegradable pins or fibrin glue ensured implant retention, but the use of pins resulted in inferior cartilage repair compared to the use of glue.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)