Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Futing Zou, Guo Wanjia, Emily J. J. Allen, Yihan Wu, Ian Charest, Thomas Naselaris, Kendrick Kay, Brice A. A. Kuhl, J. Benjamin Hutchinson, Sarah DuBrow
Summary: Using 7T fMRI, the study found that hippocampal area CA1 and the entorhinal cortex predict temporal context memory for scene images by re-expressing activity patterns during subsequent encounters over a period of months. This suggests that CA1 and the entorhinal cortex play a crucial role in preserving temporal memories.
NATURE COMMUNICATIONS
(2023)
Article
Neuroimaging
Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Marquez, Steven J. Granger, Myra S. Larson, Blake A. Miranda, Martina K. Hollearn, Liv McMillan, Bin Nan, Nicholas J. Tustison, Patrick J. Lao, Adam M. Brickman, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. . Yassa
Summary: This study examined the relationship between white matter hyperintensities, medial temporal lobe subregional volumes, and hippocampal memory in older adults. The results suggest that white matter hyperintensities may be associated with memory decline through their impact on medial temporal lobe atrophy. These findings provide new insights into the role of vascular pathologies in memory loss in older adults.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Anna-Maria Grob, Branka Milivojevic, Arjen Alink, Christian F. Doeller, Lars Schwabe
Summary: Memories are not stored in isolation. Insight into the relationship of initially unrelated events may trigger a flexible reconfiguration of the mnemonic representation of these events. However, stress impairs this process and leads to fragmented memories in PTSD. In this study, acute stress was found to reduce brain activity and disrupt the reconfiguration of memories, but interestingly, it enhanced long-term memory performance. These findings have implications for understanding memory distortions in stress-related mental disorders.
Article
Biology
Weizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem A. Zaghloul, Weiwei Zhang, Floris P. de Lange
Summary: Classic models consider working memory and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Recent evidence suggests that the medial temporal lobe may be involved in working memory, but the specific role of the entorhinal-DG/CA3 pathway in supporting precise item-specific working memory remains unclear.
Article
Neurosciences
Jingyuan Ren, Furong Huang, Chuanji Gao, Jarrod Gott, Sarah F. Schoch, Shaozheng Qin, Martin Dresler, Jing Luo
Summary: This study investigated the impact of novel stimuli on the left and right medial temporal lobes, revealing different activations in response to novel designs of different usefulness. The findings suggest that the left medial temporal lobe is predominantly involved in usefulness processing, while the right medial temporal lobe is predominantly involved in novelty processing. Additionally, the left parahippocampal gyrus showed stronger connectivity with the anterior cingulate cortex when responding to novel useless designs, while the right parahippocampal gyrus showed stronger connectivity with the amygdala, midbrain, and hippocampus.
Article
Clinical Neurology
Arthur Cukiert, Cristine Mella Cukiert, Jose Augusto Burattini, Pedro Paulo Mariani
Summary: The study investigated the outcomes of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporal lobe epilepsy. The findings showed that Hip-DBS significantly reduced seizure frequency in patients with both focal aware and focal with impaired awareness seizures, suggesting it as a promising therapeutic option for patients who are not suitable for resective surgery.
Article
Behavioral Sciences
Bohee Lee, June Sic Kim, Chun Kee Chung
Summary: Working memory is crucial for goal-directed behavior, and the frontoparietal network and medial temporal lobe play important roles in working memory. Through intracranial electroencephalography recording, it was found that low-frequency power in the frontal lobe and medial temporal lobe increased and sustained throughout the working memory task, while parietal alpha power peaked during memory operation. Furthermore, there was a positive correlation in the alpha band between the medial temporal lobe and the parietal lobe during memory operation.
Article
Geriatrics & Gerontology
Lea Chauveau, Elizabeth Kuhn, Cassandre Palix, Francesca Felisatti, Valentin Ourry, Vincent de La Sayette, Gael Chetelat, Robin de Flores
Summary: Studying the subregions of the medial temporal lobe is crucial for distinguishing age-related changes from Alzheimer's disease, with the findings highlighting the significant role of these subregions in cognitive functioning.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jax Skye, Joel Bruss, Guillaume Herbet, Daniel Tranel, Aaron D. Boes
Summary: Time orientation is a cognitive process that matches personal sense of time with a universal reference. This study investigates the neural correlates of time disorientation in patients with brain lesions. The findings suggest that lesions in the precuneus, medial temporal lobes, and occipito-temporal cortex are associated with time disorientation.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Wilma A. Bainbridge, Chris Baker
Summary: This study utilizes a large dataset from social media to investigate the neural substrates of autobiographical memories. The research finds tight interconnections among memory features and identifies a multidimensional topography in the medial parietal cortex that reflects memory content, age, and strength.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Zhemeng Wu, Mark J. J. Buckley
Summary: A number of recent studies have raised controversy about the role of the medial temporal lobe (MTL) in working memory (WM), traditionally associated with long-term memory. Factors such as stimulus set-size and feature complexity influence MTL's involvement in WM. Additionally, process-specific theories highlight the dissociations within MTL for recognition memory. Understanding the interactions between MTL and prefrontal cortex (PFC) in WM neural mechanisms is crucial for the advancement of knowledge in this area.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Christian Baeuchl, Franka Gloeckner, Christoph Koch, Johannes Petzold, Nicolas W. Schuck, Michael N. Smolka, Shu-Chen Li
Summary: The aging process leads to changes in spatial navigation behavior, with older adults relying more on proximal location cues instead of environmental boundaries. Deficient dopaminergic modulation may contribute to errors during spatial navigation in older adults. Administering levodopa in young and older adults affected brain responses and memory retrieval differently, with older adults showing upregulation in the medial temporal lobe and brainstem. While L-DOPA had no effect on older adults' overall memory performance, it improved spatial memory and increased boundary processing in some individuals.
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Maria Carolina Gonzalez, Andressa Radiske, Janine I. Rossato, Sergio Conde-Ocazionez, Lia R. M. Bevilaqua, Martin Cammarota
Summary: In this study, it was found that training adult male Wistar rats in a long-term object recognition memory (ORM)-inducing learning task increased hippocampal theta power. In addition, suppressing theta via optogenetic medial septum (MS) inactivation caused amnesia specifically for the object being explored at the time of inactivation. These findings suggest that the MS is necessary for long-term ORM formation and that hippocampal theta activity is causally linked to this process.
Article
Clinical Neurology
Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Marcus D. Wallis, Ferah Yildirim, Tracy D. Farr
Summary: This study presents a pipeline for structural and functional connectivity analysis of the mouse brain and applies it to a mouse model of vascular dementia. The findings reveal brain lesions in the model and provide insights into the mouse connectome and how it is affected by vascular insufficiency.
Article
Clinical Neurology
Julia Bungenberg, Karen Humkamp, Christian Hohenfeld, Marcus Immanuel Rust, Ummehan Ermis, Michael Dreher, Niels-Ulrik Korbinian Hartmann, Gernot Marx, Ferdinand Binkofski, Carsten Finke, Joerg B. Schulz, Ana Sofia Costa, Kathrin Reetz
Summary: This study aimed to compare persisting self-reported symptoms in initially hospitalized and non-hospitalized patients after SARS-CoV-2 infection. The results showed that patients in both groups may experience mild deficits in cognitive and memory functions, and fatigue severity was associated with reduced performance in attention and quality of life, as well as more persisting symptoms. MRI examination revealed microbleeds exclusively in hospitalized patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Letter
Clinical Neurology
Shufan Huo, Caroline Ferse, Fabian Boesl, S. Momsen Reincke, Philipp Enghard, Carl Hinrichs, Sascha Treskatsch, Stefan Angermair, Kai-Uwe Eckardt, Heinrich J. Audebert, Christoph J. Ploner, Matthias Endres, Harald Pruess, Christiana Franke, Franziska Scheibe
JOURNAL OF NEUROLOGY
(2022)
Letter
Medicine, General & Internal
Anna-Christin Willert, Christoph J. Ploner, Alexander B. Kowski
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Clinical Neurology
Martin Kenda, Zhuo Cheng, Christopher Guettler, Christian Storm, Christoph J. J. Ploner, Christoph Leithner, Michael Scheel
Summary: Background computer tomography (CT) is used to predict neurological outcome after cardiac arrest (CA). This study compared the inter-rater agreement between human and computer evaluators in determining the Gray-White-Matter Ratio (GWR) and observed deviations in individual patients. The results showed that although there were some deviations, they did not lead to false prediction of poor neurological outcomes at the given threshold.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Martina Hoffmann, Alexander Schmidt, Christoph J. Ploner
Summary: This study investigated the ability of human subjects to associate visual objects with melodies and found that even in musically untrained individuals, they have a significant ability to associate and integrate musical with visual information. The study further revealed differences in performance and mechanisms between musicians and non-musicians in the task.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Nina von Schwanenflug, Juan P. Ramirez-Mahaluf, Stephan Krohn, Amy Romanello, Josephine Heine, Harald Pruess, Nicolas A. Crossley, Carsten Finke
Summary: By investigating the spatiotemporal trajectory of meta-state transitions, this study reveals systematic alterations of transition networks in patients with anti-NMDA receptor encephalitis, suggesting a reduced stability of brain state transitions and its clinical relevance in the manifestation of the disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Stephan Krohn, Nina von Schwanenflug, Leonhard Waschke, Amy Romanello, Martin Gell, Douglas D. Garrett, Carsten Finke
Summary: The brain's large-scale functional networks are driven by temporally correlated activity across brain regions. This study reveals that the brain's network architecture is tightly linked to episodes of neural regularity, characterized by drops in complexity in functional magnetic resonance imaging signals. These drops in complexity explain functional connectivity strength, promote neural activity patterns, and reflect interindividual differences in age and behavior. Furthermore, they shape the connectivity strength, topological configuration, and hierarchy of brain networks, providing a comprehensive explanation for the structure-function relationships within the brain.
Article
Neurosciences
Sarah Herwest, Stella Linnea Kuhlmann, Anna-Christin Willert, Christoph Johannes Ploner, Alexander Bernhard Kowski
Summary: Palliative care poses significant burdens to healthcare workers, with additional challenges in neuropalliative care including patient symptom burdens and impairments. Results of the study showed that NPC physicians and nursing staff did not differ significantly from other neurological wards in terms of perceived burden and stressful deaths, with the circumstances of dying impacting distress perception. Resources mentioned were similar between groups, with team support and personal life being most important. Communication difficulties were often cited as stressful, while successful communication was seen as a valuable resource.
Article
Clinical Neurology
Patrizia M. Maier, Deetje Iggena, Thomas Meyer, Carsten Finke, Christoph J. Ploner
Summary: This study found no evidence of hippocampal dysfunction in non-demented ALS patients, suggesting that the cognitive phenotype of ALS may relate to distinct disease subtypes rather than being a variable expression of the same underlying condition.
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Michael Scheel, Harald Pruess, Carsten Finke
Summary: We found the report on unilateral cortical ribboning in a 62-year-old man with NMDA receptor antibodies interesting. Most NMDAR encephalitis patients do not have MRI abnormalities or only have subtle white matter lesions. Cortical ribboning is frequently seen in patients with Creutzfeldt-Jakob disease and those with asymmetric or strictly unilateral presentation. Additionally, NMDAR antibodies have been reported in the serum of patients with CJD, although not in the CSF.
Article
Clinical Neurology
Tim Julian Hartung, Graham Cooper, Valentin Juenger, Darko Komnenic, Lara Ryan, Josephine Heine, Claudia Chien, Friedemann Paul, Harald Pruess, Carsten Finke
Summary: NMDAR encephalitis rarely causes visible lesions in conventional MRI, but the T1w/T2w ratio can detect extensive white matter damage. This ratio could serve as a measure of cognitive impairment in NMDAR encephalitis patients and be used as an outcome measure in clinical trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Nina von Schwanenflug, Stefan P. Koch, Stephan Krohn, Tommy A. A. Broeders, David M. Lydon-Staley, Dani S. Bassett, Menno M. Schoonheim, Friedemann Paul, Carsten Finke
Summary: By applying a time-resolved graph-analytical framework, this study identifies a hyperflexible reorganization of brain activity in multiple sclerosis, characterized by increased global flexibility, promiscuity, entropy, and cohesion. This functional reorganization is linked to clinical disability, suggesting the importance of multilayer temporal dynamics in the manifestation of multiple sclerosis.
BRAIN COMMUNICATIONS
(2023)
Article
Biology
Deetje Iggena, Sein Jeung, Patrizia Maier, Christoph Ploner, Klaus Gramann, Carsten Finke
Summary: This study investigates the role of multisensory information in memory-guided spatial navigation. The results show that the availability of multisensory input improves spatial navigation in both individuals with hippocampal lesions and those without. It has a significant impact on navigational behavior, with greater improvement in spatial memory performance observed in patients. The study concludes that congruent multisensory information shifts computations to extrahippocampal areas that support spatial navigation and compensates for spatial navigation deficits.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Nina von Schwanenflug, Stephan Krohn, Josephine Heine, Friedemann Paul, Harald Pruss, Carsten Finke
Summary: The study used a dynamic functional connectivity approach to investigate the spatiotemporal variability of brain network activity in patients with anti-N-methyl-D-aspartate receptor encephalitis. The results showed distinct alterations in functional connectivity, dwell time patterns, and state transitions in patients compared to controls. The predictive power of dynamic functional connectivity models outperformed static analyses.
BRAIN COMMUNICATIONS
(2022)