期刊
NEUROPSYCHOLOGIA
卷 46, 期 2, 页码 540-553出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2007.10.003
关键词
tMRI; clustering; intrinsic activity; default-mode; hierarchy
资金
- NIMH NIH HHS [R01 MH064458, R01 MH064458-05A2] Funding Source: Medline
- PHS HHS [R01 MM 64458] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH064458] Funding Source: NIH RePORTER
Global organizational principles are critical for understanding cortical functionality. Recently, we proposed a global sub-division of the posterior cortex into two large-scale systems. One system, labeled extrinsic, comprises the sensory-motor cortex, and is associated with the external environment. The second system, labeled intrinsic, overlaps substantially with the previously described default-mode network, and is likely associated with inner-oriented processing. This global partition of the cerebral cortex emerged from hemodynamic imaging data the analysis of which was constrained by pre-determined hypotheses. Here we applied a hypothesis-free, unsupervised two-class clustering algorithm (k-means) to a large set of fMRI data. The two clusters delineated by this unsupervised hypothesis-free procedure showed high anatomical consistency across individuals, and their cortical topography coincided largely with the previously determined extrinsic and intrinsic systems. These new clusterin-based results confirm that the intrinsic-extrinsic subdivision constitutes a fundamental cortical divide. (C) 2007 Elsevier Ltd. All rights reserved.
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