Article
Nutrition & Dietetics
Karla Rio-Aige, Aina Fernandez-Bargallo, Esteban Vegas-Lozano, Antonio Minarro-Alonso, Margarida Castell, Marta Selma-Royo, Cecilia Martinez-Costa, Maria Jose Rodriguez-Lagunas, Maria Carmen Collado, Francisco Jose Perez-Cano
Summary: This study aims to characterize the dynamic changes in breast milk immune composition by analyzing various immune factors. The results show that there are differences in breast milk immune composition at different lactation stages and among different women. These dynamic compositional changes may be maternal-specific and could potentially impact infant health.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Petros Katsogiannos, Prasad G. Kamble, Maria J. Pereira, Magnus Sundbom, Per-Ola Carlsson, Jan W. Eriksson, Daniel Espes
Summary: The study compared cytokine and adipokine levels in obese patients before and after RYGB surgery, finding that despite improvements in metabolic status and weight loss, the altered cytokine profile persisted, indicating an inherent inflammatory state in obese patients.
Review
Immunology
Andrea Francesca Salvador, Kalil Alves de Lima, Jonathan Kipnis
Summary: Interactions between the immune system and the nervous system play a crucial role in shaping host behavior and nervous system function. These interactions may have evolved to maximize an organism's ability to respond to environmental threats. The immune system relays information to the nervous system through cytokine signaling, and the brain may be hardwired to process information from the immune system in a specific way.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Priscila Motta Janovits, Elbio Leiguez, Viviane Portas, Catarina Teixeira
Summary: Matrix metalloproteinases (MMPs) are enzymes associated with inflammatory diseases and obesity. Adipose tissue serves as an endocrine organ that can produce inflammatory mediators, contributing to tissue inflammation. This study investigates the inflammatory effects of a snake venom metalloproteinase (SVMP) on preadipocytes, highlighting the importance of preadipocytes as targets for metalloproteinases.
Review
Biochemistry & Molecular Biology
Tatiana V. V. Kirichenko, Yuliya V. V. Markina, Anastasia I. I. Bogatyreva, Taisiya V. V. Tolstik, Yurgita R. R. Varaeva, Antonina V. V. Starodubova
Summary: This article reviews the key functions of adipokines in the inflammatory mechanisms, complications, and associated diseases of obesity. Through an extensive search on the role of adipokines in the pathogenesis of obesity, existing research findings are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
H. L. Notbohm, F. Moser, J. Goh, J. F. Feuerbacher, W. Bloch, M. Schumann
Summary: The immune system's role in exercise responses and adaptations is important, but the impact of fluctuating hormone concentrations across the menstrual cycle on these processes is unknown. This systematic review with meta-analysis compared immune and inflammatory parameters between menstrual cycle phases. The findings suggest that certain parameters of innate immunity, such as leukocytes, monocytes, granulocytes, neutrophils, and leptin concentrations, are higher in the luteal phase compared to the follicular phase at rest. The exercise-induced response of these parameters also indicate a higher pro-inflammatory response in the luteal phase. However, more research is needed to understand the exercise responses in different hormonal profiles.
Review
Oncology
Joanna Olszanska, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak
Summary: Obesity is a rapidly growing public health problem that is a risk factor for various cancers, including melanoma. Adipokines, molecules secreted by adipose tissue, play a role in melanoma progression and may serve as markers for the disease. Understanding adipokine functions could provide insights into how obesity promotes melanoma growth and lead to potential therapeutic innovations.
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Wared Nour-Eldine, Samia M. Ltaief, Nimshitha P. Abdul Manaph, Abeer R. Al-Shammari
Summary: This systematic review investigated cytokine levels in the blood of individuals with autism and identified potential cellular sources of these cytokines. The results showed elevated levels of certain cytokines in the blood of individuals with autism, which might originate from monocytes, neutrophils, and CD4+ T cells. Other cytokines did not show significant differences between individuals with autism and the control group. These findings support existing research on abnormal cytokines in autism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Marleen Wuerfel, Jana Breitfeld, Claudia Gebhard, Markus Scholz, Ronny Baber, Steffi G. Riedel-Heller, Matthias Bluher, Michael Stumvoll, Peter Kovacs, Anke Toenjes
Summary: The study analyzed the relationship between 15 adipokines, eating behavior, and body-mass index (BMI), finding that certain adipokines are associated with different eating behavior types and BMI, with eating behavior acting as a potential mediator. Differences in mediation were observed between genders and ethnicities, highlighting the complex interplay between adipokines, eating behavior, and obesity development. Future experimental or mechanistic studies are needed to further elucidate these relationships.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ivan Belica, Katarina Jansakova, Hana Celusakova, Maria Kopcikova, Katarina Polonyiova, Barbara Raskova, Maria Vidosovicova, Daniela Ostatnikova, Katarina Babinska
Summary: Several studies have shown inconsistent results regarding the cytokine dysregulation in children with autism spectrum disorder (ASD), which has led to a debate about the immune theory of ASD and the use of cytokines as potential biomarkers. Comparisons between the cytokine levels of ASD children and their neurotypical siblings have yielded different results compared to control groups of non-siblings. Limited studies have included neurotypical siblings as control groups. This study aims to determine whether plasma cytokine levels can differentiate ASD children from their neurotypical siblings.
Review
Biochemistry & Molecular Biology
Magdalena Grazul, Pawel Kwiatkowski, Kacper Hartman, Anna Kilanowicz, Monika Sienkiewicz
Summary: Efficient functionality of the immune system is crucial in fighting against infectious diseases and modern common diseases connected with inflammation. Essential oils possess valuable properties such as antimicrobial, antioxidant, anti-inflammatory, and immunostimulating effects. Some constituents of essential oils can stimulate the proliferation of immune cells, and the interaction between essential oil components and recommended drugs should be explored for medical use.
Review
Biochemistry & Molecular Biology
Aleksandra Zawadzka, Magdalena Cieslik, Agata Adamczyk
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by deficits in social interactions, communication, and repetitive behaviors. Studies suggest a role for immune dysregulation and inflammation in the development of ASD. Infection during pregnancy can lead to oxidative stress, mitochondrial dysfunction, neuroinflammation, and neurodevelopmental pathologies in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alena Dmitrievna Khudiakova, Yana Vladimirovna Polonskaya, Victoria Sergeevna Shramko, Lilia Valeryevna Shcherbakova, Evgeniia Vitalievna Striukova, Elena Vladimirovna Kashtanova, Yulia Igorevna Ragino
Summary: The study explored the associations between adipokines/cytokines and chronic bronchitis in young people with abdominal obesity. Higher levels of adipokines and cytokines were found in patients with chronic bronchitis, while some other factors were lower. The probability of having chronic bronchitis increased with higher levels of lipocalin-2, GIP, and TNFa in the context of abdominal obesity.
Review
Multidisciplinary Sciences
XiaoLi Lin, FengMing You, Hong Liu, Yu Fang, ShuoGuo Jin, QiaoLing Wang
Summary: This study revealed a strong association between NAFLD and colon tumors, especially in the right colon, which is more prevalent among Asian populations. The risk of colorectal neoplasms was higher in patients with NAFLD, but the relationship varied depending on factors like gender and ethnicity. Advanced pathological morphologies like serrated adenomas also showed an increased risk in patients with NAFLD.
Review
Neurosciences
Lais B. Martins, Ana L. M. Silveira, Antonio L. Teixeira
Summary: This study aims to provide a comprehensive overview of the involvement of the kynurenine pathway (KP) in the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) and discuss potential therapeutic opportunities. The results showed altered levels of KP metabolites in the brains of AD and PD patients, and associations between peripheral levels of KP metabolites and cognitive function in these patients.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Clinical Neurology
Kelly Santana, Eduardo Franca, Joao Sato, Ana Silva, Maria Queiroz, Julia de Farias, Danniely Rodrigues, Iara Souza, Vanessa Ribeiro, Egas Caparelli-Daquer, Antonio L. Teixeira, Leigh Charvet, Abhishek Datta, Marom Bikson, Suellen Andrade
Summary: This study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCs) combined with a rehabilitation program for the management of PASC-related fatigue. The results showed that active HD-tDCS significantly reduced fatigue, decreased anxiety, and improved quality of life compared to sham HD-tDCS.
Article
Neurosciences
Haitham Salem, Robert Suchting, Mitzi M. Gonzales, Sudha Seshadri, Antonio L. Teixeira
Summary: This study aimed to detect conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and determine the effect of apathy on the progression to AD in patients with MCI. The study found that 17.3% of individuals had conversion from MCI to AD over a period of 8.21 years. Patients with apathy had a higher conversion rate and shorter time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Eliana C. B. Toscano, Erica L. M. Vieira, Lea T. Grinberg, Natalia P. Rocha, Joseane A. S. Brant, Regina S. Paradela, Alexandre V. Giannetti, Claudia K. Suemoto, Renata E. P. Leite, Ricardo Nitrini, Milene A. Rachid, Antonio L. Teixeira
Summary: Temporal lobe epilepsy (TLE) is associated with cognitive deficits, and this study investigates the underlying neuronal basis. The researchers found that an increase in p-tau burden is potentially involved in cognitive deficits in mesial TLE, particularly attention impairment and seizure frequency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina de Almeida Prado, Fabiola Tavares, Mayra Tavares, Francisco Cardoso, Antonio Jaeger, Leonardo Cruz de Souza, Antonio Lucio Teixeira
Summary: The International Parkinson's Disease and Movement Disorder Society (MDS) developed diagnostic criteria for mild cognitive impairment (MCI) and dementia in Parkinson disease (PD). However, the applicability of these criteria was limited for PD patients with low levels of formal education in Brazil. There is a need for revision of the guidelines to account for differences among populations, especially related to educational level.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Multidisciplinary Sciences
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Summary: This systematic review evaluated the accuracy of long non-coding RNAs (lncRNAs) in identifying Alzheimer's disease (AD) through meta-analysis. The results showed that lncRNAs had high accuracy in identifying AD and could be considered a promising diagnostic biomarker for the disease.
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Review
Rheumatology
Parnian Shobeiri, Saba Maleki, Mobina Amanollahi, Amirhossein Habibzadeh, Antonio L. Teixeira, Nima Rezaei
Summary: This study aimed to investigate the blood BDNF levels in patients with SLE. The meta-analysis of 8 studies showed no significant differences in blood BDNF concentrations between SLE patients and healthy controls. Further high-quality studies are needed to explore the potential role and relevance of BDNF in SLE.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Antonio L. Teixeira, Lais Bhering Martins, Thiago Macedo e Cordeiro, Lijin Jose, Robert Suchting, Holly M. Holmes, Ron Acierno, Hyochol Ahn
Summary: This study aims to evaluate the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) for the treatment of apathy in Alzheimer's disease (AD). A randomized, sham-controlled pilot clinical trial will be conducted involving 40 subjects with AD, with their caregivers administering tDCS at home under remote televideo supervision. The findings from this study will contribute to the development of non-pharmacological treatment strategies and have great potential for clinical translation.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Geriatrics & Gerontology
Natalia P. Rocha, Antonio L. Teixeira, Gabriela D. Colpo, Michelle A. Babicz, Jennifer L. Thompson, Steven Paul Woods
Summary: This study found a significant association between plasma levels of neurofilament light chain (NfL) and HIV-associated neurocognitive disorders (HANDs), suggesting that NfL may serve as a promising biomarker for assessing cognitive function in people living with HIV.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
