Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Absalon D. Gutierrez, Carlos A. Flores, Sapna Naik, MinJae Lee, Parisa Asgarisabet, Masha Resman, Miryoung Lee, Joseph B. McCormick, Susan P. Fisher-Hoch
Summary: Resistin decreased as glucose tolerance deteriorated, positively associated with IL-1 beta and IL-8, inversely associated with TNF-alpha, and not significantly associated with IL-6. There are complex relationships between resistin, adipokines, and demographic variables.
Review
Cell Biology
Alin Garcia-Miranda, Alejandra Garcia-Hernandez, Eduardo Castaneda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
Summary: Excess body weight and obesity have been identified as significant risk factors for cancer development, with adipokines playing a crucial role in promoting an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Autophagy, a process implicated in both tumor suppression and cancer progression, has been suggested as a therapeutic target in cancer treatment, with its effectiveness potentially influenced by tumor type and microenvironmental conditions influenced by circulating adipokines.
Article
Sport Sciences
Lucelia Scarabeli Silva Barroso, Marcelo Henrique Salviano Faria, Antonio Felipe Souza-Gomes, Joao Luis Vieira Monteiro Barros, Adriana Maria Kakehasi, Erica Leandro Marciano Vieira, Ana Cristina Simoes e Silva, Albena Nunes-Silva
Summary: Adipose tissue produces and releases adipokines, and exercise can modulate adipokine production in adipocytes. The aim of this longitudinal study was to evaluate the acute and chronic effects of strength training on plasma levels of adiponectin, leptin, and resistin. The results showed that strength training acutely and chronically affected the levels of adipokines in the blood.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrea Marcinno, Erica Gallo, Fausto Roveta, Silvia Boschi, Alberto Grassini, Innocenzo Rainero, Elisa Rubino
Summary: This study investigated the expression of adiponectin, leptin, and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). The results showed that lower resistin concentrations were associated with an increased risk of dementia, particularly in AD. The study suggests that the resistin-linked metabolic profile should be further investigated in AD.
Article
Biochemistry & Molecular Biology
Fabio Perrotta, Filippo Scialo, Marta Mallardo, Giuseppe Signoriello, Vito D'Agnano, Andrea Bianco, Aurora Daniele, Ersilia Nigro
Summary: This study investigated the relationship between obesity and COVID-19, specifically analyzing the levels of adiponectin, HMW oligomers, leptin, and resistin in severe COVID-19 patients. The results showed that total adiponectin levels were lower, while leptin and resistin levels were higher in severe COVID-19 patients compared to healthy individuals. HMW adiponectin oligomers were negatively correlated with leptin and positively associated with lung injury scores. Resistin showed a positive association with IL-6, IL-2R, and KL-6. These findings suggest that adipose tissue plays a functional role in COVID-19, and HMW adiponectin oligomers may serve as a laboratory resource for predicting disease severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Elina J. Reponen, Martin Tesli, Ingrid Dieset, Nils Eiel Steen, Trude S. J. Vedal, Attila Szabo, Maren C. F. Werner, Synve H. Lunding, Ingrid T. Johansen, Linn N. Rodevand, Ole A. Andreassen, Thor Ueland
Summary: Leptin and adiponectin levels are elevated in patients with severe mental illnesses, and adiponectin is significantly associated with cardiovascular disease risk, independent of diagnosis and medication regimes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Kyoung Eun Joung, Sheryl L. Rifas-Shiman, Emily Oken, Christos S. Mantzoros
Summary: The study found a positive association between maternal prepregnancy BMI and the risk of ASD in children, and a negative association between higher levels of adiponectin during pregnancy and the risk of ASD in children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Martina Platzer, Frederike T. Fellendorf, Susanne A. Bengesser, Armin Birner, Nina Dalkner, Carlo Hamm, Melanie Lenger, Alexander Maget, Rene Pilz, Robert Queissner, Bernd Reininghaus, Alexandra Reiter, Harald Mangge, Sieglinde Zelzer, Hans-Peter Kapfhammer, Eva Z. Reininghaus
Summary: This study explores the underlying causes of obesity and weight gain in bipolar disorder, as well as the associations between food craving, clinical parameters, psychotropic medication, and appetite-related hormones. Results show that individuals with bipolar disorder have higher food craving frequencies compared to healthy controls, with a significant negative correlation between food craving and ghrelin levels. Smoking status and age are significantly associated with food craving intensity, and different medication therapies also influence food craving levels.
Review
Physiology
Lubica Cibickova, Michal Grega, Roman Dohnal, Jan Schovanek
Summary: Bariatric procedures, particularly laparoscopic sleeve gastrectomy (LSG), are highly effective in treating obesity. LSG leads to weight loss and metabolic improvement, as well as changes in adipokine levels. Adipokines, including leptin, resistin, visfatin, chemerin, adiponectin, and omentin, play a crucial role in regulating insulin resistance and chronic inflammation, and are significantly altered after LSG.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Psychiatry
Petros Petrikis, Andreas Karampas, George Leondaritis, Georgios Markozannes, Dimitra T. Archimandriti, Polyxeni Spyrou, Georgios Georgiou, Petros Skapinakis, Paraskevi V. Voulgari
Summary: This study compared serum levels of adiponectin, resistin, and leptin between drug-naive first-episode patients with psychosis and healthy controls, as well as the changes after six weeks of antipsychotic treatment. The results showed significantly higher levels of these adipokines in the patient group before treatment, and a significant reduction in leptin levels after six weeks of treatment.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Psychology, Clinical
Erika F. H. Saunders, Dahlia Mukherjee, Daniel A. Waschbusch, Duanping Liao, Amanda M. Pearl, Errol Aksu, Edward O. Bixler
Summary: The use of structured interviews helped physicians identify major depressive disorder by the second visit in patients with complex psychopathology. Patients with high complexity/severity of symptoms and more difficulty with functioning were less commonly identified with bipolar disorder even with the assistance of a structured interview.Structured assessment tools may improve the detection of psychiatric illness by clinicians at the first visit.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Leonid Braverman, Camil Fuchs, Abraham Weizman, Michael Poyurovsky
Summary: Evidence suggests a higher comorbidity rate of obsessive-compulsive disorder (OCD) in bipolar disorder (BD) patients, particularly in those experiencing bipolar depression (BP-D). A study found 26% of BD patients with their first depressive episode also had OCD, while 23.2% met criteria for subthreshold OCD. No differences in demographic and clinical variables were observed between BD patients with and without OCD. Further research is needed to explore the longitudinal course, treatment approaches, and outcomes of comorbid BP-D/OCD.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study developed a new measure for identifying bipolar disorder, comparing the classification accuracy of a weighting rating scale with equivalent weightings for each item. Results showed that both methods had extremely high classificatory accuracy, and identified optimal cut-off scores for diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.