期刊
NEUROPSYCHOBIOLOGY
卷 65, 期 1, 页码 45-54出版社
KARGER
DOI: 10.1159/000329105
关键词
5-HTTLPR; Anhedonia; Depression; Stress; Reward; Resilience
资金
- Harvard College
- NIMH [R01MH68376, R21MH078979]
- Harvard University
- Sackler Scholar in Psychobiology Research Grant
- GlaxoSmithKline
- ANT North America Inc. (Advanced Neuro Technology)
- AstraZeneca
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH068376, R21MH078979] Funding Source: NIH RePORTER
Background: Stressful life experiences frequently precede the onset of major depression; however, the mechanisms that underlie this link are poorly understood. Importantly, some individuals are more susceptible to the depressogenic effects of stress than others. Carriers of the S or L G allele of the 5-HTTLPR/ rs25531 polymorphisms (S' participants) have been found to be more prone to developing depression under stress relative to L or L A homozygotes (L' participants). Moreover, emerging evidence indicates that stress-induced anhedonia may be a mechanism underlying links between stress and depression. Given these findings, we hypothesized that exposure to a naturalistic stressor (school final examinations) would disrupt reward responsiveness (a key behavioral component of anhedonia), and that this effect would be strongest in S' participants. Methods: To objectively assess reward responsiveness, we administered a probabilistic reward task to 70 Bulgarian high school students over two sessions in the 6-month period preceding school finals. For each participant, the two sessions were designated as the 'stress' and 'control' conditions based on self-reported perceived stress. Results: A genotype ! condition interaction emerged in males, with S' participants showing larger stress-related reduction in reward responsiveness relative to L' participants. Conclusion: While in need of replication in a larger sample, our results indicate that stress associated with a real-life event is linked to reduced reward responsiveness, the susceptibility to which is modulated by 5-HTTLPR/rs25531 genotype. Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression. Copyright (C) 2011 S. Karger AG, Basel
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