Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Gianmarco De Felice, Mario Luciano, Alessia Boiano, Giulia Colangelo, Pierluigi Catapano, Bianca Della Rocca, Maria Vita Lapadula, Elena Piegari, Claudia Toni, Andrea Fiorillo
Summary: This review examines the role of brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD) and investigates its potential as a biomarker for BD. The results show a decrease in circulating levels of BDNF during acute phases of BD compared to healthy controls, which increase after effective therapy. The Val66Met polymorphism is associated with features typically linked to worse outcomes. While more research is needed, BDNF appears to be a promising biomarker for BD.
Article
Clinical Neurology
Bun-Hee Lee, Young-Min Park, Jung-A Hwang, Yong-Ku Kim
Summary: The study revealed that patients with suicidal MDD had lower plasma BDNF levels and higher Epo levels. Using ROC curve analysis, a significant association was found between high Epo and low BDNF status and suicidal MDD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Burak Baykara, Dogukan Koc, Halil Resmi, Pinar Akan, Zeliha Tunca, Aysegul Ozerdem, Deniz Ceylan, Neslihan Gurz Yalcin, Nagihan Cevher Binici, Sevay Alsen Guney, Esther Mesman, Manon H. J. Hillegers, Neslihan Inal Emiroglu
Summary: This study compared peripheral BDNF levels between pediatric and adult BD patients and found that BDNF levels were significantly lower in pediatric BD patients than in adult BD patients, which could potentially serve as a marker to distinguish pediatric BD patients from healthy controls. Furthermore, higher BDNF levels in adult BD were associated with later disease onset, but this association was not observed in pediatric BD patients. Additionally, reduced BDNF levels were associated with illness duration in adult BD patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Ziwei Teng, Lu Wang, Sujuan Li, Yuxi Tan, Yan Qiu, Chujun Wu, Kun Jin, Jindong Chen, Jing Huang, Hui Tang, Hui Xiang, Bolun Wang, Hui Yuan, Haishan Wu
Summary: The study found significantly lower BDNF levels in patients with Bipolar Type II disorder (BD II) compared to patients with Major Depressive Disorder (MDD) and healthy controls. BD II and MDD patients showed similar cognitive deficits in attention, delayed memory, and RBANS total score. BDNF levels were positively associated with visuospatial/constructional and Stroop color-word in the BD II group, and with language in the MDD group.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Nanna Aagaard Petersen, Marc Ostergaard Nielsen, Klara Coello, Sharleny Stanislaus, Sigurd Melbye, Hanne Lie Kjaerstad, Kimie Stefanie Ormstrup Sletved, Roger S. McIntyre, Ruth Frikke-Smith, Maj Vinberg, Lars Vedel Kessing
Summary: The study found that BDNF levels are not decreased in individuals with newly diagnosed bipolar disorder and their unaffected first-degree relatives, but rather slightly elevated compared to healthy controls, contrasting with previous findings during later stages of the illness.
Article
Psychiatry
Erik Smedler, Erik Palsson, Kenji Hashimoto, Mikael Landen
Summary: Variation in the CACNA1C gene is associated with bipolar disorder, affecting serum levels of BDNF and tissue plasminogen activator. This reveals links between CACNA1C genetic variants and pathophysiological mechanisms in bipolar disorder.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Luyu Ding, Yifan Wu, Lingtao Kong, Jiaze Sun, Fangru Qu, Kaiqi Xin, Anqi Yang, Xintong Yan, Yihui Lu, Xiaowei Jiang, Yanqing Tang, Feng Wu
Summary: This study investigates whether the glial cell line-derived neurotrophic factor (GDNF) levels differ in terms of gender in patients with bipolar disorder (BD). The results show that in the healthy control group, males have significantly higher GDNF levels compared to females, while in the BD group, males have significantly lower GDNF levels compared to males in the healthy control group.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Esmail Jamshidi, Adrian E. Desai Bostrom, Alexander Wilczek, Asa Nilsonne, Marie Asberg, Jussi Jokinen
Summary: This study found that brain-derived neurotrophic factor (BDNF) is associated with the pathogenesis of emotionally unstable personality disorder (EUPD) and suicidal behavior. Epigenetic alterations of BDNF were observed in severely impaired EUPD and suicidal patients. The findings contribute to a better understanding of the mechanisms underlying suicide and EUPD and may lead to the development of novel treatment methods.
Article
Biochemistry & Molecular Biology
Weronika Zwolinska, Maria Skibinska, Agnieszka Slopien, Monika Dmitrzak-Weglarz
Summary: This study aimed to compare serum levels of BDNF, proBDNF, and S100B before and after treatment for acute depressive episodes and assess their correlation with symptom severity and stress history. The results showed a significant decrease in proBDNF levels after treatment, while BDNF and S100B levels did not change significantly. Thus, a decrease in serum proBDNF levels may be considered a biomarker of recovery from depressive episodes.
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Ursula Pauli-Pott, Alisa Susann Cosan, Susan Schloss, Nadine Skoluda, Urs M. Nater, Susanne Tumala, Johannes Kruse, Eva M. J. Peters
Summary: The study found that hair-derived BDNF concentration (HBC) is associated with anxiety/depressive symptoms and can predict the development of these symptoms. However, HBC is not associated with the development of ADHD symptoms. This study adds evidence to the validity of the BDNF hair analysis method.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Lin-Shuai Hao, Yang Du, Lei Chen, Yu-Guo Jiao, Yong Cheng
Summary: The present study conducted a systematic review with meta-analysis to compare peripheral blood BDNF levels between patients with OCD and healthy controls. The results showed that patients with OCD had significantly decreased peripheral blood levels of BDNF compared to the healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Zuxing Wang, Zhili Zou, Jun Xiao, Wenjiao Min, Li-Ping Nan, Cui Yuan, Lu Yuan, Chenghui Yang, Rui Huang, Ying He
Summary: Multiple studies have shown that electroconvulsive therapy (ECT) can increase brain-derived neurotrophic factor (BDNF) concentrations in patients with different mental disorders. The aim of this synthesis was to evaluate post-ECT BDNF concentrations in patients with various mental disorders. The standardized mean difference (SMD) was calculated to quantify BDNF concentration differences.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Mikhail S. Zinchuk, Alla B. Guekht, Tatiana A. Druzhkova, Natalia Gulyaeva, Alexander A. Shpak
Summary: This study aimed to evaluate the concentration of GDNF in tears and serum of patients with a current depressive episode. The results showed that GDNF concentration in the serum was significantly lower in women with MDD, and in BD patients, there was a significant correlation between GDNF concentration in tears and the use of anxiolytics or antidepressants. A significant correlation between GDNF concentrations in tears and serum was found in the control group. In conclusion, GDNF concentration in tears could be a biomarker of the current depressive episode.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Automation & Control Systems
Subramanian Kuppusamy, Young Hoon Joo
Summary: This article investigates the switched fault-tolerant tracking control techniques for a permanent magnet synchronous generator (PMSG)-based variable-speed wind energy conversion system (WECS) subject to actuator faults. The proposed fault-tolerant tracking control effectively tracks the optimal trajectory of the system states under known and unknown actuator faults. Stabilization conditions and H-infinity performance index are derived to enhance system performance.
INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING
(2023)
Article
Engineering, Electrical & Electronic
Raghul Venkateswaran, Anto Anbarasu Yesudhas, Seong Ryong Lee, Young Hoon Joo
Summary: This paper investigates the control strategy for extracting stable output power and regulating DC-link voltage in a permanent-magnet vernier generator (PMVG)-based wind turbine system (WTS). An integral sliding mode controller (ISMC) is presented for the machine-side converter (MSC) to maximize output power, and a grid-side converter (GSC) is also designed to protect the DC-link and maintain steady output power. The exponential reaching law is employed to ensure stable output power during various wind speed conditions.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Engineering, Mechanical
Pratap Anbalagan, Young Hoon Joo
Summary: This study investigates a dissipative-based fuzzy sampled-data control scheme for stabilizing a variable-speed wind turbine system and enhancing its dynamic performance using a fragmented-delayed state looped functional framework.
NONLINEAR DYNAMICS
(2023)
Article
Green & Sustainable Science & Technology
Raghul Venkateswaran, Balasubramani Natesan, Seong Ryong Lee, Young Hoon Joo
Summary: This study proposes a Q-learning MPPT algorithm with FTC scheme for maximum power extraction in a PMVG-based WECS. A model-free sensorless reinforcement Q-learning algorithm-based MPPT method is firstly introduced, followed by the construction of an optimal speed-power curve using the proposed learning algorithm. Additionally, a wind-speed change detection algorithm and FTC method are implemented to ensure the adaptability and stability of the PMVG-based WECS.
IEEE TRANSACTIONS ON SUSTAINABLE ENERGY
(2023)
Article
Automation & Control Systems
Kumarasamy Palanimuthu, Ganesh Mayilsamy, Seong Ryong Lee, Sang Yong Jung, Young Hoon Joo
Summary: This article investigates fault ride-through capability for a grid-connected permanent magnet vernier generator (PMVG)-based wind turbine system (WTS) using coordinated active and reactive power control strategy. The proposed control methods demonstrate their superiority through simulations on 5-kW PMVG, 1.5 MW PMSG-based WTS, and its application potential is shown through the experimental prototype of a 5-kW PMVG-based WTS.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Computer Science, Information Systems
Dinesh Elayaperumal, Young Hoon Joo
Summary: This work proposes a multi-expert deep feature fusion method based on the learning spatial variance-key surrounding-aware correlation filter (LSVKSCF) to address various problems in continuous object tracking. By extracting surrounding samples, introducing selective spatial information, and utilizing spatial variance information, this method effectively handles scale changes, occlusion, and boundary effects, achieving good tracking performance on multiple datasets.
INFORMATION SCIENCES
(2023)
Article
Automation & Control Systems
Shanmugam Lakshmanan, Young Hoon Joo
Summary: This article investigates the robust stability of PMSG-based WT systems with ROUs under a fuzzy sampled-data control scheme. The uncertainties in the d-q inductance, system inertia, and stator resistance are considered and modeled as ROUs using white noise sequences. A fuzzy-based sampled-data control is designed to achieve stability against uncertainties and disturbances. Linear matrix inequalities based on looped-Lyapunov functionals are derived to ensure the stability of the T-S fuzzy model for the nonlinear PMSG-based WTs. The derived conditions are validated and compared to show their less conservative nature.
INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING
(2023)
Article
Automation & Control Systems
Shanmugam Lakshmanan, Young Hoon Joo
Summary: This paper presents a decentralized observer-based control scheme for large-scale interconnected systems using the integral sliding mode control (ISMC) approach. A novel decentralized observer is designed to estimate the unmeasured states. Sufficient conditions for the asymptotic stability of the interconnected system and the ultimate boundedness of estimation errors are derived using matrix inequality. Numerical simulations validate the theoretical conditions and demonstrate the effectiveness of the proposed control scheme in an interconnected power system with a DFIG-based wind farm.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Automation & Control Systems
Subramanian Kuppusamy, Young Hoon Joo
Summary: This study proposes a nonparallel distribution compensation (PDC) control method for PMSG-based wind energy conversion systems (WECS). By expressing the nonlinear PMSG-based WECS as a Takagi-Sugeno (T-S) fuzzy system, a general non-PDC control strategy is designed via a T-S fuzzy observer. The observer is used to estimate the unmeasurable states of the system, and sufficient conditions are obtained to ensure the stability of the system.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Dongran Song, Ziqun Li, Xiaofei Deng, Mi Dong, Lingxiang Huang, Jian Yang, Mei Su, Younghoon Joo
Summary: Because wind direction is time-varying, yaw is a common state of wind turbines. To improve energy capture and reduce the usage of yaw actuators, a Model Predictive Control (MPC) method based on Fuzzy Deduction Weight Coefficient Evaluator (FDWE) is proposed. The FDWE dynamically adjusts the weight coefficient connecting the objectives of energy capture loss ratio and yaw actuator usage ratio in MPC based on predicted wind direction. Three different strategies are proposed to optimize the fuzzy rule and membership function as part of this complex optimization problem. The results show that the optimized FDWE-MPC using these strategies improves energy capture and reduces yaw actuator usage, indicating promise in reducing production costs for wind turbines.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Automation & Control Systems
Ruban Periyanayagam Antonysamy, Seong Ryong Lee, Sang Yong Jung, Young Hoon Joo
Summary: This study proposes a robust sliding mode approach-based current control scheme for the machine side converter and grid side converter of a grid-connected permanent magnet vernier generator (PMVG). The proposed scheme improves steady-state and transient performance, reduces total harmonic distortion in grid current, and enhances power quality. Simulation and experimental results demonstrate the effectiveness of the proposed controller compared to conventional methods.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Raghul Venkateswaran, Seong Ryong Lee, Young Hoon Joo
Summary: This paper proposes a stability augmentation scheme using the e1 adaptive scheme for pitch angle control in a PMSG-based wind turbine system with pitch actuator uncertainty. This scheme regulates the pitch angle and maintains the rated rotor speed in the presence of pitch actuator uncertainties. The proposed e1 adaptive scheme is applied to a non-affine PMSG system with uncertainties for variable-speed WTS. The stability and performance of the proposed scheme are proven through bound conditions.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Subramanian Kuppusamy, Young Hoon Joo
Summary: This paper proposes novel stabilization criteria for a nonlinear permanent magnet synchronous generator (PMSG)-based wind turbine system (WTS) with sampled-data information under uncertainty and controller gain variations. The nonlinearity in the PMSG-based WTS is modeled using Takagi-Sugeno (T-S) fuzzy systems. A novel looped-type asymmetric augmented Lyapunov-Krasovskii functional (LKF) is developed by taking advantage of the variable characteristic related to the sampling pattern. The dynamic delay partition method is used for the non-fragile sampled-data control design of the T-S fuzzy systems, and the less conservative stabilization criteria are obtained in the form of linear matrix inequality.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Automation & Control Systems
Sathiyamoorthi Arthanari, Young Hoon Joo
Summary: This study presents a memory sampled-data control design for the Takagi-Sugeno (T-S) fuzzy-based permanent magnet synchronous generator (PMSG) via an improved looped functional (ILF). The proposed method models the nonlinear PMSG as a T-S fuzzy system and introduces a novel ILF to derive the sufficient criteria. The stabilizsation conditions expressed as linear matrix inequalities (LMIs) ensure the asymptotic stability of the closed-loop system.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Automation & Control Systems
Gandhi Velmurugan, Young Hoon Joo
Summary: In this study, a coupled fuzzy controller design was proposed for stabilizing a continuous nonlinear system with external perturbations represented by Takagi-Sugeno fuzzy systems. The controller was developed using non-parallel distributed compensation techniques and a non-quadratic Lyapunov functional was utilized. Stabilization conditions were formulated as linear matrix inequalities using the time derivatives of the non-QLF and Jensen's inequality techniques, ensuring stochastic asymptotic stability of the system with $H_{\infty}$ perturbation damping criterion. Two simulation results were presented to validate the proposed methodologies.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
