Article
Chemistry, Medicinal
Jae Youn Kim, Chang Hyeon Kong, Do Yeon Kim, Ji Won Min, Keontae Park, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jong Hoon Ryu
Summary: In this study, we investigated the potential of D-pinitol to ameliorate schizophrenia-like behaviors induced by MK-801. The results showed that single administration of D-pinitol improved sensorimotor gating deficits, social behavior deficits, and cognitive impairments induced by MK-801 without causing motor coordination deficits.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Ho Jung Bae, Jae Youn Kim, Seung-Hyuk Choi, So-Yeon Kim, Hyun-Jeong Kim, Ye Eun Cho, Yu-Yeong Choi, Ju-Yeon An, So-Young Cho, Jong Hoon Ryu, Se Jin Park
Summary: This study found that Cynanchum paniculatum has the potential to improve schizophrenia-like behaviors induced by MK-801, and paeonol, the major component, could be a treatment for schizophrenia. Paeonol can reverse prepulse deficits in acoustic startle response test, attenuate social novelty preference and novel object recognition memory. In addition, it can reverse abnormal signaling pathways and inflammatory factors in the prefrontal cortex.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Masahito Sawahata, Hiroki Asano, Taku Nagai, Norimichi Ito, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
Summary: The study showed that microinjection of recombinant Reelin into the medial prefrontal cortex prevented recognition memory impairment induced by MK-801, highlighting the potential therapeutic effects of Reelin on cognitive deficits associated with schizophrenia. Despite this positive effect, Reelin treatment did not ameliorate deficits in sensory-motor gating and short-term memory in the animal model of schizophrenia. The results suggest that Reelin acts on its receptors to suppress neural activity in the mPFC, thereby preventing cognitive deficits induced by MK-801.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Neurosciences
Jinwei Xu, Yaohao Li, Biqing Tian, Haiying Liu, Shengxi Wu, Wenting Wang
Summary: This article investigates the effect of environmental enrichment on cognitive symptoms in schizophrenia and explores the significance of NMDA receptor hypofunction in cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hyo Jeoung Bae, Ho Jung Bae, Jae Youn Kim, Keontae Park, Xingquan Yang, Seo Yun Jung, Se Jin Park, Dong Hyun Kim, Chan Young Shin, Jong Hoon Ryu
Summary: Schizophrenia is associated with neuroinflammation and elevated cytokine levels. Lansoprazole, a proton pump inhibitor, has been found to reduce neurotoxicity and inflammatory cytokines. This study investigated whether lansoprazole could ameliorate schizophrenia-like symptoms in mice. Results showed that lansoprazole improved sensorimotor gating deficits, spatial learning, and social deficits, without causing motor coordination deficits. Lansoprazole also decreased inflammatory cytokines in the cortex but not in the hippocampus. These findings suggest that lansoprazole could be a potential treatment for schizophrenia patients with specific symptoms, without motor-related adverse effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Chemistry, Multidisciplinary
Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin
Summary: Increasing evidence suggests that chronic nicotine treatment can alleviate MK-801-induced schizophrenia-like symptoms and cognitive impairment in mice. This study found that nicotine treatment reversed the increased expression levels of PDZ and LIM domain 5 (Pdlim5) and prevented the decrease in CREB-regulated transcription coactivator 1 (CRTC1) in the prefrontal cortex (PFC), resulting in improved cognition in mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Plant Sciences
Yongwoo Jeong, Ho Jung Bae, Keontae Park, Hyo Jeoung Bae, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu
Summary: Scrophularia buergeriana may be a potential treatment for mental illness, especially schizophrenia, by supplying kidney Yin and reducing blood heat to alleviate symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jia-Quan Liang, Xi Chen, Yong Cheng
Summary: The study demonstrates that paeoniflorin can alleviate schizophrenia-like behaviors through inhibiting the oxidative stress pathway. The potential mechanisms of restoring neuronal expression and preventing neurotoxicity were also revealed.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zhu
Summary: Treatment with MK-801 enhances proliferation of hippocampal astrocytes and upregulates BDNF mRNA expression. The NMDA, PI3K, and ERK1/2 signaling pathways may be involved in regulating MK-801-induced BDNF upregulation. These findings suggest that astrocytes may play a role in the acute neurological and behavioral response to MK-801 treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Sema Oral, Gokhan Goktalay
Summary: By disrupting prepulse inhibition (PPI) modeling of schizophrenia, rats can be divided into different groups based on baseline PPI values, showing varying responses to pharmacological agents. Amphetamine disrupted PPI in both low and high inhibitory groups, while other agents only affected PPI levels in the high inhibitory group.
NEUROSCIENCE LETTERS
(2021)
Article
Pharmacology & Pharmacy
Patrick Latuske, Moritz von Heimendahl, Serena Deiana, Carsten T. Wotjak, Johann du Hoffmann
Summary: Cognitive flexibility is crucial for healthy functioning and is often impaired in neuropsychiatric diseases. Probabilistic reversal learning (PRL), a commonly used method to measure cognitive flexibility, is often limited in rodents. A novel rat PRL task that occurs at longer intervals demonstrates increased sensitivity to drugs, offering potential for testing and developing novel treatments for cognitive impairment in human patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Mitra Khakpoor, Salar Vaseghi, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Mohammad Nasehi
Summary: The research revealed that GABA-B receptors in the BLA area can modify the impairing effect of MK-801 on passive avoidance memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Environmental Sciences
Murat Sirri Akosman, Ruhi Turkmen, Hasan Huseyin Demirel
Summary: The study demonstrated that resveratrol has a protective effect against glial cell infiltration and shrinkage of nerve cell nuclei induced by MK-801 in the brain. However, it did not correct behavioral disorders and demyelination of schizophrenia. Resveratrol partially prevented oxidative damage but not significantly.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Psychiatry
Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomon
Summary: NMDA receptor blockade in rodents can induce schizophrenia-like behavioral abnormalities, and the endocannabinoid system can modulate these abnormalities. The study shows that anandamide hydrolysis inhibitor can reverse the behavioral deficits induced by NMDA receptor blocker in adolescence. It also suggests that endocannabinoid stimulation may have therapeutic potential in treating treatment-resistant symptoms.
SCHIZOPHRENIA BULLETIN
(2022)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.