Article
Clinical Neurology
Wylie Y. Lopez, Brian C. Goh, Shivam Upadhyaya, Chason Ziino, Peter J. Georgakas, Anmol Gupta, Daniel G. Tobert, Harold A. Fogel, Thomas D. Cha, Joseph H. Schwab, Christopher M. Bono, Stuart H. Hershman
Summary: A retrospective study found that 91.2% of patients with CSM were radiographically candidates for LP, indicating that LP may be an underutilized procedure for the treatment of CSM.
Article
Health Care Sciences & Services
Peter Obid, Anastasia Rakow, Gernot Michael Lang, Wolfgang Marx, Thomas Niemeyer, Tamim Rahim
Summary: This study evaluated the clinical and radiological outcomes of cervical disc arthroplasty (CDA) using the CP ESP(R) disc prosthesis in patients with cervical spondylotic myelopathy (CSM). The results showed that CDA achieved good clinical and radiological outcomes in these young patients, with preserved motion of the index segments. CDA may be a viable treatment option for selected patients with CSM.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Ni, Xiaoyi Wen, Mengze Zhang, Chenyu Jiang, Yali Li, Ben Wang, Xianchang Zhang, Qiang Zhao, Ning Lang, Liang Jiang, Huishu Yuan
Summary: This study explored the preoperative dMRI parameters to predict the postoperative outcome of CSM through multifactor correlation analysis. The FA value based on dMRI significantly positively correlated with CSM patient postoperative outcomes, helping to predict the surgical outcome and formulate a treatment plan before surgery.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Wei Du, Hai-Xu Wang, Jing-Tao Zhang, Feng Wang, Xu Zhang, Yong Shen, Rong Chen, Li Zhang
Summary: This study compared the surgical efficacy of anterior decompression with fusion (ADF) vs. posterior decompression with fixation (PDF) for treating kyphotic cervical spondylotic myelopathy (KCSM). The results showed significant differences in cervical spinal alignment parameters and axial symptoms severity between the two surgical approaches, with better outcomes observed in the ADF group. Surgeons should carefully weigh the pros and cons of each approach when deciding on a surgical plan for KCSM patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Masaaki Machino, Kei Ando, Kazuyoshi Kobayashi, Hiroaki Nakashima, Shunsuke Kanbara, Sadayuki Ito, Taro Inoue, Keigo Ito, Fumihiko Kato, Naoki Ishiguro, Shiro Imagama
Summary: This study aimed to characterize risk factors for poor outcomes following cervical laminoplasty in patients with cervical spondylotic myelopathy (CSM). Factors such as older age, longer duration of CSM symptoms, and lower preoperative 10-second step test score were identified as significant risk factors for poor outcomes.
Article
Multidisciplinary Sciences
Kosei Nagata, Junya Miyahara, Hideki Nakamoto, Naohiro Kawamura, Yujiro Takeshita, Akiro Higashikawa, Takashi Ono, Masayoshi Fukushima, Rentaro Okazaki, Nobuhiro Hara, So Kato, Toru Doi, Yuki Taniguchi, Yoshitaka Matsubayashi, Sakae Tanaka, Yasushi Oshima
Summary: This retrospective study analyzed 339 patients who underwent laminoplasty for cervical spondylotic myelopathy and found that the presence of diabetes did not adversely affect pain or patient-reported outcome measures (PROMs) one year after surgery, indicating that preoperative diabetes does not have a negative impact on postoperative recovery.
SCIENTIFIC REPORTS
(2022)
Article
Computer Science, Artificial Intelligence
Bing Ji, Qihang Dai, Xinyu Ji, Weiming Wu, Qinghua Sun, Hecheng Ma, Menglin Cong, Lei Cheng, Cong Wang, Meng Si, Wei Zeng
Summary: In this study, a dynamic method for the detection of cervical spondylotic myelopathy (CSM) is proposed based on the nonlinear dynamics of the gait system and deterministic learning theory. Discriminant kinematic gait features are extracted using a 3D gait analysis system, and the dynamics of the gait system are modeled and identified using deterministic learning theory. The method achieves high accuracy in classifying and detecting CSM, making it a potential candidate for automatic detection in clinical examination.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Neurosciences
Guang-Sheng Li, Xu-Xiang Wang, Ron-Bang Tan, Kang-Heng Wang, Xiao-song Hu, Yong Hu
Summary: This study explored the ultrastructural pathology of the neurovascular unit (NVU) during the natural development of cervical spondylotic myelopathy (CSM). The findings revealed the crucial pathophysiological mechanisms of CSM through the ultrastructural destruction of NVU.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Rehabilitation
Min Yao, Zhen-jun Li, Bin Zhu, Bao-ping Xu, Sen Zhu, Yan-fang Pan, Xiao-tao Wang, Zi-rui Tian, Zhen Deng, Jie Ye, Yong-jun Wang, Xue-jun Cui
Summary: This study aimed to validate the simplified Chinese version of the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) for Chinese patients with cervical spondylotic myelopathy (CSM). The results showed that the scale had good construct validity, convergent validity, internal consistency reliability, and test-retest reliability. However, there was a ceiling effect.
DISABILITY AND REHABILITATION
(2022)
Article
Biochemistry & Molecular Biology
Guang-Sheng Li, Guang-Hua Chen, Kang-Heng Wang, Xu-Xiang Wang, Xiao-Song Hu, Bo Wei, Yong Hu
Summary: This study investigates the involvement of compensatory changes in the neurovascular unit (NVU) in the natural course of spontaneous functional recovery (SFR) in cervical spondylotic myelopathy (CSM) using an experimental CSM model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Zhengran Yu, Wenxu Pan, Jiacheng Chen, Xinsheng Peng, Zemin Ling, Xuenong Zou
Summary: Degenerative cervical myelopathy (DCM) is a major cause of progressive spinal cord dysfunction in the elderly, and early diagnosis and treatment are crucial. Electrophysiological studies play an important role in the management of DCM, detecting pathological changes, assessing severity, predicting prognosis, and monitoring during surgery and rehabilitation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Zoher Ghogawala, Norma Terrin, Melissa R. Dunbar, Janis L. Breeze, Karen M. Freund, Adam S. Kanter, Praveen V. Mummaneni, Erica F. Bisson, Fred G. Barker, J. Sanford Schwartz, James S. Harrop, Subu N. Magge, Robert F. Heary, Michael G. Fehlings, Todd J. Albert, Paul M. Arnold, K. Daniel Riew, Michael P. Steinmetz, Marjorie C. Wang, Robert G. Whitmore, John G. Heller, Edward C. Benzel
Summary: In patients with cervical spondylotic myelopathy undergoing cervical spinal surgery, a ventral surgical approach did not significantly improve patient-reported physical functioning at 1 year compared with outcomes after a dorsal surgical approach. Rates of complications were higher in the ventral surgery group, including dysphagia, neurological deficits, reoperations, and readmissions.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Kyohei Sakaki, Kenichiro Sakai, Yoshiyasu Arai, Ichiro Torigoe, Masaki Tomori, Takashi Hirai, Hiroaki Onuma, Yutaka Kobayashi, Atsushi Okawa, Toshitaka Yoshii
Summary: This study investigated the postoperative dysphagia in cervical posterior longitudinal ligament ossification (C-OPLL) and cervical spondylotic myelopathy (CSM) to identify the risk factors of each disease and the incidence. The results showed that increased angle C2-7 was a risk factor for both diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hamid Hassanzadeh, Joshua Bell, Evan Dooley, Varun Puvanesarajah, Pramod Kamalapathy, Lawal Labaran, Adam Shimer, Francis Shen, Shawn Russell
Summary: This prospective cohort study compares the postural stability and spatiotemporal gait parameters of preoperative cervical spondylotic myelopathy (CSM) patients with healthy controls. The study finds that CSM patients have poorer postural stability and exhibit slower, shorter, and wider gait patterns compared to controls. They also spend more time in double support and have increased whole-body movement to maintain balance.
Article
Medicine, General & Internal
Hea-Eun Yang, Wan-Tae Kim, Dae-Hyun Kim, Seok-Woo Kim, Woo-Kyoung Yoo
Summary: Diffusion tensor imaging (DTI) and magnetization transfer (MT) magnetic resonance imaging (MRI) can detect spinal cord pathology and provide microstructural information. This study analyzed the parameters of major motor and sensory tracts and found correlations between DTI parameters and clinical symptoms at the lesion level.
Article
Clinical Neurology
Wei-Jin Wong, Dar-Ming Lai, Shwu-Fen Wang, Jaw-Lin Wang, Wei-Li Hsu
Article
Biology
Mohammad Nikkhoo, Chih-Hsiu Cheng, Jaw-Lin Wang, Zahra Khoz, Marwan El-Rich, Nader Hebela, Kinda Khalaf
COMPUTERS IN BIOLOGY AND MEDICINE
(2019)
Article
Acoustics
Ya-Cherng Chu, Jormay Lim, Cheng-Wei Hong, Yeh-Shiu Chu, Jaw-Lin Wang
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2019)
Article
Acoustics
Ya-Cherng Chu, Jormay Lim, Wen-Hao Hwang, Yu-Xuan Lin, Jaw-Lin Wang
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Chih-Hsiu Cheng, Dar-Ming Lai, Phooi Yee Lau, Shwu-Fen Wang, Andy Chien, Jaw-Lin Wang, Wei-Li Hsu
SCIENTIFIC REPORTS
(2020)
Article
Acoustics
Ya-Cherng Chu, Jormay Lim, Mu-Cyun Tseng, Jaw-Lin Wang
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2020)
Article
Anesthesiology
Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Chu-Ting Chang, Min-Hsuan Li, Ya-Cherng Chu, Jaw-Lin Wang, Ke-Vin Chang, Shing-Hong Lin, Chih-Cheng Chen
Summary: The study found that dextrose injections can reduce mechanical hypersensitivity in a mouse model of fibromyalgia. The effectiveness of this treatment depends on the type of injectant, dose, and volume, but not on osmolarity. The antinociceptive effects are mediated through the activation of ASIC1a and substance P signaling pathways in muscle afferents. This study provides insights into the mechanism of action of dextrose prolotherapy in noninflammatory muscle pain and potential treatments for other chronic pain conditions.
Article
Engineering, Biomedical
Chi-Ying Lee, Shih Chieh Lan, Jung-Ji Lin, Yu-Ting Lin, Po-Shen Chiang, Wei-Li Hsu, Kuo-Kuang Jen, Andy Y. S. Huang, Jia-Yush Yen
Summary: The study modeled natural human motion using a biped robot simulator and examined the effects of exoskeleton assistance and energy consumption. Virtual parallel bars were found to effectively assist the robot in simulating a natural walking gait.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Jormay Lim, Ya-Cherng Chu, Hsiao-Hsin Tai, Andy Chien, Shao-Shiang Huang, Chih-Cheng Chen, Jaw-Lin Wang
Summary: This study quantified the optimal ultrasound dosage and long-term effects of transcranial ultrasound treatments for brain diseases. It was found that transcranial ultrasound promotes the increase of neural progenitors and this effect lasts at least a week, unaffected by auditory toxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Acoustics
Ya-Cherng Chu, Jormay Lim, Andy Chien, Chih-Cheng Chen, Jaw-Lin Wang
Summary: This review examines the effects of ultrasound on mechanosensitive channels (MSCs), summarizes the conditions for ultrasound activation of these channels, and explores the biological effects of ultrasound in therapeutic applications. The findings suggest that only a limited number of MSCs are activated by ultrasound, and provide insights into the ion channels and molecular mechanisms involved. These results contribute to the design of more effective ultrasound stimulation devices.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Health Policy & Services
Phunsuk Kantha, Jiu-Jenq Lin, Wei-Li Hsu
Summary: This study investigates the effects of interactive virtual reality (iVR) on pain, psychological distress, and functional disability in patients with chronic musculoskeletal disorders compared with no rehabilitation and conventional rehabilitation. The results suggest that iVR can reduce pain and improve psychological distress.
GAMES FOR HEALTH JOURNAL
(2023)
Article
Clinical Neurology
Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Ke-Vin Chang, Shing-Hong Lin, Ya-Cherng Chu, Jaw-Lin Wang, Chih-Cheng Chen
Summary: Therapeutic ultrasound has analgesic effects against chronic muscle pain by activating ASIC3-containing channels and releasing substance P in muscle afferents.
Article
Acoustics
Ya-Cherng Chu, Chien-Ying Ho, Yue Chuo, Hao-Hsuan Wu, Jaw-Lin Wang
Summary: A closed-form solution for the minimal focal distance with a given transducer size was derived in this study to facilitate precise focal spot alignment with targets in the mouse brain. An iterative algorithm based on Snell's law was introduced for lens profile calculation, enabling the acquisition of an accurate lens profile for the minimal focal distance.
JASA EXPRESS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jormay Lim, Yu-Cheng Liu, Ya-Cherng Chu, Yu-Xuan Lin, Wen-Hao Hwang, Jaw-Lin Wang
Summary: Research on chondrocytes suggests that ultrasound and piezoelectricity influence cell migration and ciliary orientation, potentially opening up new possibilities for cellular modulation.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Engineering, Biomedical
Phunsuk Kantha, Shiow-Chwen Tsai, Chien-Wen Hou, Rong-Sen Yang, Pei-Yu Su, Wei-Li Hsu
Summary: In older adults with hyperkyphosis, bone mineral content (BMC) and muscle mass are correlated with walking and forward reach, while BMI and fat mass show no significant correlation with balance performance.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2021)