Review
Pharmacology & Pharmacy
Yiwei Huang, Yuyun Song, Jichen Li, Changning Lv, Zhe-Sheng Chen, Zhijun Liu
Summary: Human herpes simplex viruses use cell surface receptors such as heparan sulfate, herpesvirus entry mediator, and nectin-1/-2, 3-O-sulfated heparan sulfate to enter host cells. No vaccine or curative treatment is currently available for HSV infections.
DRUG DISCOVERY TODAY
(2022)
Article
Multidisciplinary Sciences
Kristine Farmen, Sara K. Nissen, Morten G. Stokholm, Alex Iranzo, Karen Ostergaard, Monica Serradell, Marit Otto, Kristina B. Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Moller, Carles Gaig, David J. Brooks, Eduardo Tolosa, Nicola Pavese, Marina Romero-Ramos
Summary: This study found abnormal monocytic markers in the peripheral blood of iRBD patients, which were associated with brain inflammation and neuronal dysfunction. The findings suggest a cross-talk between the peripheral and brain in synucleinopathy-related disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Irene Hernandez-Lozano, Severin Mairinger, Thomas Filip, Michael Sauberer, Thomas Wanek, Johann Stanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer
Summary: The study demonstrates that P-glycoprotein can affect the pulmonary disposition of inhaled drugs, with decreased P-gp activity potentially leading to lower lung exposure and decreased therapeutic efficacy. PET imaging with intratracheally aerosolized radiotracers shows promise for assessing the impact of membrane transporters on pulmonary drug delivery in both rodents and potentially in humans.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Virology
Md Sadique Hussain, Gaurav Gupta, Vijaya Paul Samuel, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Shakir Saleem, Ruqaiyah Khan, Najla Altwaijry, Samir Patel, Archita Patel, Sachin Kumar Singh, Kamal Dua
Summary: The immunopathology of HSV-associated neuroinflammation is a complex field of study that explores the interactions between the virus and the host's immune responses, as well as the impact of immune reactions on the outcome of infections. This review extensively analyzes the diverse immune reactions triggered by HSV and delves into the delicate balance between immune defense and immunopathology-induced neural damage.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Immunology
Kuriko Kagitani-Shimono, Hiroki Kato, Ryoko Kuwayama, Koji Tominaga, Shin Nabatame, Haruhiko Kishima, Jun Hatazawa, Masako Taniike
Summary: Neuroinflammation, visualized using translocator protein positron emission tomography with [C-11] DPA713, was found to be sensitive in identifying epileptic foci in child-onset focal epilepsy. The inflammation was implicated in the pathophysiology of epileptic foci caused by various etiologies, indicating a need for further research in diagnostic tools for identifying focal epileptogenic zones.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Review
Clinical Neurology
Peng-Fei Zhang, Fan Gao
Summary: Neuroinflammation may play a role in the progression of Parkinson's disease, as evidenced by elevated TSPO levels in various brain regions of PD patients compared to healthy controls. The involvement of neuroinflammation in PD pathogenesis remains ambiguous, with contrasting outcomes depending on the ligand used in the study.
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer M. Coughlin, Stephanie Slania, Yong Du, Laura K. Shinehouse, Mary Katherine Brosnan, Babak Behnam Azad, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Il Minn, Steven P. Rowe, Robert F. Dannals, Andrew G. Horti, Martin G. Pomper
Summary: The study demonstrated that [F-18]FNDP PET can be used to study sEH in the human brain. Results showed that [F-18]FNDP had stable and reliable performance in the brains of healthy adults.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nisha K. Ramakrishnan, Matthew Hird, Stephen Thompson, David J. Williamson, Luxi Qiao, David R. Owen, Allen F. Brooks, Peter J. H. Scott, Sergio Bacallado, John T. O'Brien, Franklin Aigbirhio
Summary: This study evaluated the two enantiomers of [F-18]GE387, showing that (S)-[F-18]GE387 has favorable kinetics in healthy subjects and can distinguish inflamed brain regions in neuroinflammation models, while also demonstrating low sensitivity to TSPO polymorphism in human brain tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang, Steven H. Liang
Summary: The 18 kDa translocator protein (TSPO) plays a key role in neuroinflammation and several TSPO-targeted PET tracers have been developed, some of which have advanced to clinical research studies.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Cell Biology
Kiel D. Neumann, Donna K. Broshek, Benjamin T. Newman, T. Jason Druzgal, Bijoy K. Kundu, Jacob E. Resch
Summary: Sport concussion affects millions of athletes each year. Research has shown inconsistent definitions in clinical and physiological recovery, as demonstrated by studies on blood-based biomarkers and CNS imaging. Recent studies indicate elevated microglial activation in the CNS of football players and diagnosed collegiate athletes, suggesting a discrepancy between clinical symptoms and inflammatory response. This review summarizes recent advances in understanding the inflammatory response associated with sport concussion and outlines important research questions for aligning clinical and physiological recovery.
Article
Anesthesiology
Christina Mueller, Yu-Hua D. Fang, Chloe Jones, Jonathan E. Mcconathy, Fabio Raman, Suzanne E. Lapi, Jarred W. Younger
Summary: This study found increased binding of the translocator protein radioligand in several brain regions among fibromyalgia patients. The results suggest that individuals with fibromyalgia may have higher levels of neuroinflammation than healthy controls. Additionally, the study found higher binding levels in multiple brain regions among high-affinity binders in the fibromyalgia group. The differences in the right parietal gray matter were associated with decreased quality of life, higher pain severity and interference, and cognitive problems.
Review
Clinical Neurology
Chris W. J. van der Weijden, Emma Biondetti, Ingomar W. Gutmann, Hildebrand Dijkstra, Rory McKerchar, Daniele de Paula Faria, Erik F. J. de Vries, Jan F. Meilof, Rudi A. J. O. Dierckx, Valentin H. Prevost, Alexander Rauscher
Summary: Myelin is a protective sheath made of phospholipid bilayer and water that wraps around axons. Non-invasive quantitative myelin imaging methods are needed for evaluating myelin damage, assessing the efficacy of remyelination therapies, and monitoring brain maturation in children. Different MRI and PET techniques have been developed for myelin imaging based on various biophysical principles. This review provides an overview of these techniques, including image acquisition, data analysis, and validation status, and concludes that quantitative susceptibility mapping, inhomogeneous magnetization transfer for MRI, and C-11-MeDAS for PET are the most promising techniques.
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, Rudi A. J. O. Dierckx, Janine Doorduin
Summary: Major depressive disorder is a growing and poorly understood pathology that requires research in animal paradigms due to technical and ethical limitations. PET imaging has been used in preclinical studies to investigate glucose metabolism, neuroreceptor populations, and the inflammatory response associated with depressive phenotypes. This review summarizes the findings in animal models and discusses the relevance of PET imaging for understanding depression and developing new therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Pascalle Mossel, Anna L. Bartels, Rudi A. J. O. Dierckx, Gert Luurtsema, Adriaan A. Lammertsma, Antoon T. M. Willemsen, Erik F. J. de Vries
Summary: Pharmacokinetic modelling with arterial sampling is the gold standard for analyzing dynamic PET data of the brain, but it has limited clinical application due to its invasive nature. Non-invasive methods, such as population based input function (PBIF), image derived input function (IDIF), and simultaneous estimation of the input function (SIME), have been proposed as alternatives. This systematic review assesses the correspondence of these non-invasive methods with the gold standard and highlights the need for validation before clinical implementation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Psychology, Clinical
Iris Jonker, Janine Doorduin, Henderikus Knegtering, Erna Van't Hag, Rudi A. Dierckx, Erik F. J. de Vries, Robert A. Schoevers, Hans C. Klein
Summary: This study aimed to determine whether add-on treatment of schizophrenic patients with the anti-viral drug valaciclovir would reduce hippocampal neuroinflammation and improve cognitive symptoms. Results showed that valaciclovir treatment reduced neuroinflammation in multiple brain regions, but had no effect on psychotic symptoms or cognitive functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Cyprien G. J. Guerrin, Janine Doorduin, Kavya Prasad, Daniel A. Vazquez-Matias, Lara Barazzuol, Erik F. J. de Vries
Summary: Early adverse experiences increase vulnerability to immune challenges later in life, especially when they occur during brain development. This study found that male rats exposed to social defeat during juvenile age showed enhanced anhedonia and social interaction dysfunction after an immune challenge in adulthood, while rats exposed to social defeat during adulthood did not exhibit this enhanced susceptibility. Additionally, exposure to social defeat during juvenile age increased microglia cell density and glial reactivity to the immune challenge more than exposure during adulthood.
NEUROBIOLOGY OF STRESS
(2023)
Article
Behavioral Sciences
Cyprien G. J. Guerrin, Erik F. J. de Vries, Kavya Prasad, Daniel A. Vazquez-Matias, Lesley E. Manusiwa, Lara Barazzuol, Janine Doorduin
Summary: Prenatal immune activation and postnatal immune challenge had a significant impact on behavior in female rats. The combination of maternal immune activation and immune challenge during adolescence resulted in long-lasting changes in social behavior and locomotion. These findings highlight the importance of immune activation and challenge during critical periods of development.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychology, Clinical
Anne-Sophie D. Enthoven, Shiral S. Gangadin, Lieuwe de Haan, Wim Veling, Erik F. J. de Vries, Janine Doorduin, Marieke J. H. Begemann, Iris E. C. Sommer
Summary: Childhood trauma may impact the severity of depressive and negative symptoms in patients with schizophrenia spectrum disorders, with differences between sexes. Depressive symptoms in men were associated with total trauma scores and emotional abuse, while in women they were associated with sexual abuse. Negative symptoms in men were linked to total trauma scores and emotional neglect, while in women there was no clear link potentially due to statistical power limitations.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Cyprien G. J. Guerrin, Kavya Prasad, Daniel A. Vazquez-Matias, Jing Zheng, Maria Franquesa-Mullerat, Lara Barazzuol, Janine Doorduin, Erik F. J. de Vries
Summary: Maternal infection during pregnancy and childhood social trauma affect behavior and synaptic density, possibly due to changes in microglial cells and cytokine release.
NEUROBIOLOGY OF STRESS
(2023)
Review
Oncology
Jasper J. L. van Geel, Erik F. J. de Vries, Michel van Kruchten, Geke A. P. Hospers, Andor W. J. M. Glaudemans, Carolina P. Schroder
Summary: Molecular imaging, such as PET, is being used more frequently as a biomarker to predict and assess treatment response in breast cancer. Specific tracers are used to measure metabolic activity, estrogen receptor expression, and human epidermal growth factor receptor 2 expression. These biomarkers have potential in predicting treatment response and outcome, but more studies are needed before implementation in clinical practice.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Toxicology
Didima M. G. de Groot, Louisa Linders, Reinier Kayser, Rianne Nederlof, Celine de Esch, Roderick C. Slieker, C. Frieke Kuper, Andre Wolterbeek, V. Jeroen de Groot, Andor Veltien, Arend Heerschap, Aren van Waarde, Rudi A. J. O. Dierckx, Erik F. J. de Vries
Summary: This study investigated the impact of environmental chemicals on brain development and found that di-n-octyltin dichloride (DOTC) can affect both structural and functional brain development. The study also revealed the involvement of immune system development and functioning in the impairment of the nervous system. These findings support the close connection between the immune and nervous systems in brain development.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.